Ultraearly hematoma growth predicts poor outcome after acute intracerebral hemorrhage

Rodríguez‐Luna, David; Rubiera, Marta; Ribó, Marc; Coscojuela, Pilar; Piñeiro, Socorro; Pagola, Jorge; Hernández-Guillamón, Mar; Ibarra, B; Romero, Francisco J.; Alvarez-Sabin, José; Montaner, Joan; Molina, Carlos A.

doi:10.1212/wnl.0b013e3182343387

Cited by 104 publications

(90 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 Similarly to ICH, perihematomal edema increases over time 2,6,7 by ≈75% of relative volume during the first 24 hours in patients scanned within the first 3 hours from symptom onset. 2 Although baseline ICH volume has been shown to be associated with hematoma expansion, 20,22 the relationship between baseline perihematomal edema volume and hematoma expansion has not been well established. The CTA spot sign is a powerful predictor of hematoma expansion 15 and represents a surrogate of active bleeding.…”

Section: February 2016mentioning

confidence: 99%

“…The CTA spot sign is a powerful predictor of hematoma expansion 15 and represents a surrogate of active bleeding. [22][23][24][25][26] We hypothesized that lower relative perihematomal edema volume may suggest a early time point from onset or actively bleeding ICH and, therefore, present a high likelihood of both CTA spot sign positivity and hematoma expansion at 24 hours. However, relative perihematomal edema volume was not significantly correlated with onset-CT time within the first 6 hours in our study.…”

Section: February 2016mentioning

confidence: 99%

See 1 more Smart Citation

Perihematomal Edema Is Greater in the Presence of a Spot Sign but Does Not Predict Intracerebral Hematoma Expansion

Rodríguez‐Luna¹,

Dowlatshahi²,

Kosior³

et al. 2016

Stroke

View full text Add to dashboard Cite

Intracerebral hemorrhage (ICH) initiates a secondary injury cascade inducing perihematomal edema development within 3 hours from symptom onset. 1 Perihematomal edema increases over time by ≈100% of absolute volume within the first 24 hours.2 However, the relationship among perihematomal edema, ICH volume, and hematoma expansion has not been well established.Background and Purpose-Perihematomal edema volume may be related to intracerebral hemorrhage (ICH) volume at baseline and, consequently, with hematoma expansion. However, the relationship between perihematomal edema and hematoma expansion has not been well established. We aimed to investigate the relationship among baseline perihematomal edema, the computed tomographic angiography spot sign, hematoma expansion, and clinical outcome in patients with acute ICH. Methods-Predicting Hematoma Growth and Outcome in Intracerebral Hemorrhage Using Contrast Bolus CT (PREDICT) was a prospective observational cohort study of ICH patients presenting within 6 hours from onset. Patients underwent computed tomography and computed tomographic angiography scans at baseline and 24-hour computed tomography scan. A post hoc analysis of absolute perihematomal edema and relative perihematomal edema (absolute perihematomal edema divided by ICH) volumes was performed on baseline computed tomography scans (n=353). Primary outcome was significant hematoma expansion (>6 mL or >33%). Secondary outcomes were early neurological deterioration, 90-day mortality, and poor outcome. Results-Absolute perihematomal edema volume was higher in spot sign patients (24.5 [11.5-41.8

show abstract

Section: February 2016mentioning

confidence: 99%

Section: February 2016mentioning

confidence: 99%

Perihematomal Edema Is Greater in the Presence of a Spot Sign but Does Not Predict Intracerebral Hematoma Expansion

Rodríguez‐Luna¹,

Dowlatshahi²,

Kosior³

et al. 2016

Stroke

View full text Add to dashboard Cite

show abstract

“…8,9 However, most ICHs are supratentorial and the influence of supratentorial ICH location on outcome remains unclear. Lobar ICH may have a better prognosis in comparison with ICH in other locations, [10][11][12][13] or it may not, [14][15][16][17][18][19][20] and the risk of recurrence may be higher after lobar ICH. 21 Determining whether risk factors and outcome differ according to ICH location has been further complicated by studies' varied definitions of ICH location.…”

mentioning

confidence: 99%

Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome

Samarasekera

Fonville

Lerpiniere

et al. 2015

Stroke

151

106

View full text Add to dashboard Cite

Background and Purpose-The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because of differences in the distribution of underlying cerebral small vessel diseases. Therefore, we investigated the incidence, characteristics, and outcome of lobar and nonlobar ICH. Methods-In a population-based, prospective inception cohort study of ICH, we used multiple overlapping sources of case ascertainment and follow-up to identify and validate ICH diagnoses in 2010 to 2011 in an adult population of 695 335. Results-There were 128 participants with first-ever primary ICH. The overall incidence of lobar ICH was similar to nonlobar ICH (9.

show abstract

“…Although previous studies showed that HE predominantly occurred within 6 hours from symptoms onset [12], both frequency and timing of HE varied widely in other studies [11,13]. This may be due to different criteria for HE, as well as to the variability in the time from ICH onset to imaging [12].…”

Section: Discussionmentioning

confidence: 88%

“…However, subsequent studies demonstrated that hematomas expansion (HE) over time, which has been attributed to persistent extravasation from the primary source and to the mechanical disruption of surrounding vessels [11]. Although previous studies showed that HE predominantly occurred within 6 hours from symptoms onset [12], both frequency and timing of HE varied widely in other studies [11,13]. This may be due to different criteria for HE, as well as to the variability in the time from ICH onset to imaging [12].…”

Section: Discussionmentioning

confidence: 99%

Intracerebral haemorrhage growth is influenced by anticoagulation intensity

Ye¹,

Leonid²,

Paltoglou³

et al. 2017

Neurol Disord Therap

View full text Add to dashboard Cite

Background: Intracerebral hemorrhage (ICH) is a significant contributor to global health-related morbidity and mortality. Due to improved recognition and treatment of atrial fibrillation by antithrombotics, there is an increase in proportion of ICH caused by warfarin and novel oral anticoagulants. However, the relationship between anticoagulation intensity and hematoma expansion remains unclear. We aimed to investigate the effects of international normalized ratio (INR) on hematoma expansion post ICH.

show abstract

Ultraearly hematoma growth predicts poor outcome after acute intracerebral hemorrhage

Abstract: The uHG represents a powerful and easy-to-use tool for improving the prediction of HG and outcome in patients with acute ICH.

Cited by 104 publications

References 17 publications

Perihematomal Edema Is Greater in the Presence of a Spot Sign but Does Not Predict Intracerebral Hematoma Expansion

Perihematomal Edema Is Greater in the Presence of a Spot Sign but Does Not Predict Intracerebral Hematoma Expansion

Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome

Intracerebral haemorrhage growth is influenced by anticoagulation intensity

Contact Info

Product

Resources

About