Ultradian rhythms in canine gallbladder bile composition

A review of the physiology of the canine digestive tract related to the development ofin vitrosystems

“…During feeding the gall bladder bile concentration shows circadian rhythms peaking immediately before meal time in all biliary compounds (Camello et al 1991). This finding suggests that periodic food ingestion plays a role in the circadian rhythms of gall bladder bile composition (Camello et al 1991). The duodenal activity has also an influence on Table 8.…”

“…Amount, secretion time and composition of the pancreatic juice with different types and amounts of food given to dogs (Stevens & Hume, 1995) Amount .1-8.2 0.2-1.1 ml/min 8400-9700 mg/l 14000-63900 mg/l 4800-22000 mg/l 0.9-1 .O mmol/l 71-1 06 mmol/l 0.1-1.7 mmol/l 2.5-7.0 mmol/l 142-162 mmol/l 93-143 mmol/l 0.4-1.8 mmol/l 250 mg/l 5000-48000 mg/l 240-585 mg/l 1000-9360 mg/l 748-843 mg/l 18&840 mg/l 0.1-0.7 mmol/l 23900-47500 mg/lt an inducer of circadian rhythms in the gall bladder. These contractionrelaxation cycles are synchronized with periodic dilutionconcentration processes (Camello et al 1991). The gall bladder empties only partially (5-65 %; median 31 %) after a meal (Rothuizen et al 1990).…”

“…Values for the gall bladder half-emptying time t l / 2 of 47.3 f 4.7 min and for the curve shape parameter S of 0.866 f 0.036 were reported by Jonderko et al (1994). During feeding the gall bladder bile concentration shows circadian rhythms peaking immediately before meal time in all biliary compounds (Camello et al 1991). This finding suggests that periodic food ingestion plays a role in the circadian rhythms of gall bladder bile composition (Camello et al 1991).…”

“…The remainder is directly released into the duodenum (Rothuizen et al 1990). Bile is stored in a concentrated form and is actively evacuated into the duodenum in response to the ingestion of a meal (Camello et al 1991). Therefore bile from the gall bladder differs in concentration from bile directly secreted from the liver (Table 9).…”