Ultradian Oscillations of Plasma Glucose, Insulin, and C Peptide in Man During Continuous Enteral Nutrition

Simon, Chantal; Brandenberger, G.; Follénius, M.

doi:10.1210/jcem-64-4-669

Cited by 141 publications

(96 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The glucose oscillations, varying in number in each subject, display a periodicity of 51 to 112 min, which is similar to that previously described in man during continuous enteral nutrition [8]. The oscillations amplitude is highest immediately after meals, decreasing and becoming less regular with time, especially during the night.…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Postprandial oscillations of plasma glucose, insulin and C-peptide in man

Simon

Follénius²,

Brandenberger³

1987

Diabetologia

Self Cite

View full text Add to dashboard Cite

Summary. Postprandial plasma glucose, insulin and C-peptide profiles were studied in eight normal subjects, in the afternoon or in the evening. Two to five synchronous oscillations, with a mean period of 51 to 112 min were detected. The oscillations were highest after meals and were then damped, reverting to fasting levels after up to 340 min. Additional short-term oscillations, with periods of 20-30 min and 9-14 min, were observed. Cross-correlation studies of glucose and insulin and of insulin and C-peptide revealed a high correlation in the frequency bands considered. The synchronous oscillations of insulin and C-peptide suggest cyclic variations in pancreatic secretion rather than cyclic changes in insulin degradation.

show abstract

Section: Discussionsupporting

confidence: 83%

“…We recently described the existence of 53-113 min oscillations of plasma glucose, insulin and C-peptide levels in man during continuous enteral nutrition [8]. This study was designed to establish whether similar oscillations occur in the postprandial state.…”

mentioning

confidence: 99%

Postprandial oscillations of plasma glucose, insulin and C-peptide in man

Simon

Follénius²,

Brandenberger³

1987

Diabetologia

Self Cite

View full text Add to dashboard Cite

show abstract

“…Through biological experiments it has been well-established [6,9,17,18] that insulin secretion in the pancreas oscillates on a number of different time scales, ranging from tens of seconds to more than 100 minutes. The oscillations with larger period (80-150 mins) are known as ultradian oscillations and a model developed by Sturis et al [19] (see also Keener & Sneyd [7]) provides a possible mechanism for their origin.…”

Section: Introductionmentioning

confidence: 99%

Global stability in a model of the glucose-insulin interaction with time delay

Bennett

Gourley

2004

Eur. J. Appl. Math

View full text Add to dashboard Cite

A variety of models on the interaction between glucose and insulin have been suggested over the last 50 years. One, developed by Sturis et al. [19], and consisting of six nonlinear ordinary differential equations, has been widely accepted. However, the model has the disadvantage of containing auxiliary variables which have no clinical interpretation. In this paper we study an alternative model which incorporates a time delay explicitly, negating the need for the auxiliary equations. A simplifying assumption of having just one insulin compartment reduces the number of equations still further. We then study the resulting system of two differential delay equations, establishing results on positivity, boundedness, persistence and global asymptotic stability. For the latter, two quite different approaches are employed: comparison principles and Lyapunov functionals. The two approaches provide different sets of sufficient conditions for global stability, so that we investigate different regions of parameter space.

show abstract

“…Recent studies have demonstrated that the majority, if not all, of normal insulin secretion occurs as pulsatile bursts (5,6). In healthy humans, high-frequency insulin concentration pulses recurring at intervals between 6 and 13 min have been reported (4,6) along with oscillations of larger amplitude and a longer periodicity of ~120 min (7,8). The cellular mechanisms that generate and regulate oscillatory insulin secretion by the ␤-cell are elusive, although a pivotal role of phosphofructokinase M has been suggested recently (9,10).…”

mentioning

confidence: 99%

Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.

et al. 2000

View full text Add to dashboard Cite

Insulin is released in high-frequency pulsatile bursts at intervals of 6-13 min. Intrapancreatic mechanisms are assumed to coordinate pulsatile insulin release, but small oscillations in plasma glucose concentrations may contribute further. To gain additional insight into ␤-cell (patho)physiology, we explored the ability of repetitive small glucose infusions (6 mg/kg over 1 min every 10 min) to modify rapid pulsatile insulin secretion in 10 type 2 diabetic individuals (plasma glucose 9.3 ± 1.0 mmol/l, HbA 1c 7.9 ± 0.5%, mean ± SE) and 10 healthy subjects. All subjects were investigated twice in randomly assigned order: during saline and during glucose exposure. Blood was collected every minute for 90 min to create a plasma insulin concentration time-series for analysis using 3 complementary algorithms: namely, spectral analysis, autocorrelation analysis, and approximate entropy (ApEn). During saline infusion, none of the algorithms were able to discriminate between diabetic and control subjects (P > 0.20). During glucose entrainment, spectral density peaks (SP) and autocorrelation coefficients (AC) increased significantly (P < 0.001), and ApEn decreased (P < 0.01), indicating more regular insulin time-series in the healthy volunteers. However, no differences were observed in the diabetic individuals between the glucose and saline conditions. Even elevating the glucose infusion rate in the diabetic subjects to achieve comparable relative (and hence higher absolute) glucose excursions (~4.9%) failed to entrain pulsatile insulin secretion in this group. In conclusion, the present study demonstrates that failure to respond adequately with regular oscillatory insulin secretion to recurrent high-frequency and (near)-physiological glucose excursion is a manifest feature of ␤-cell malfunction in type 2 diabetes. Whether the model will be useful in unmasking subtle (possible prediabetic) defects in ␤-cell sensitivity to glucose drive remains to be determined.

show abstract

Ultradian Oscillations of Plasma Glucose, Insulin, and C Peptide in Man During Continuous Enteral Nutrition

Cited by 141 publications

References 29 publications

Postprandial oscillations of plasma glucose, insulin and C-peptide in man

Postprandial oscillations of plasma glucose, insulin and C-peptide in man

Global stability in a model of the glucose-insulin interaction with time delay

Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes.

Contact Info

Product

Resources

About