Ultracentrifugation for ultrafine nanodiamond fractionation

Koniakhin, Sergei V.; Besedina, Nadezhda A.; Kirilenko, D. A.; Shvidchenko, A. V.; Eidelman, E. D.

doi:10.1016/j.spmi.2017.10.039

Cited by 20 publications

(15 citation statements)

References 33 publications

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“…Fractionation of NDs was investigated previously [ 25 , 26 , 29 , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , 76 ]. However, optical spectra of different fractions have not been considered in detail.…”

Section: Resultsmentioning

confidence: 99%

“…However, optical spectra of different fractions have not been considered in detail. Previously, it was found that non-diamond carbon could be removed from ND fractions [ 39 ] and the fractions have different surface chemical composition and therefore physicochemical properties [ 40 , 76 ], which apparently may affect the optical properties. Thus, we used centrifugation to see in more detail how the UV/vis spectrum and absorption at 532 nm by OA measurements depend on fraction size and composition.…”

Section: Resultsmentioning

confidence: 99%

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Absorption spectra of nanodiamond aqueous dispersions by optical absorption and optoacoustic spectroscopies

et al. 2018

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The multispectral modality and technique for optically dense samples of optoacoustic spectroscopy were applied to measure spectra and high absorbances of concentrated aqueous dispersions of undoped nanodiamonds. The data from optoacoustic and optical transmission measurements and DSC data of the mean particle size by the Gibbs–Kelvin equation are compared to estimate the difference in composition of various nanodiamond trademarks. Optoacoustic spectra confirm the contribution of surface dimer chains into the absorption of nanodiamonds in the long wavelength range. Optoacoustic and conventional absorption spectra of aqueous solutions of nanodiamond fractions after centrifugation (15300g) and ultracentrifugation (130000g) revealed a separation of a highly absorbing non-diamond sp2 phase. The two-step separation by ultracentrifugation followed by extra centrifugation made it possible to isolate a highly absorbing and soluble nanodiamond phase with the particle size of 3.6 nm, showing a change in spectra compared to the starting nanodiamond material.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Absorption spectra of nanodiamond aqueous dispersions by optical absorption and optoacoustic spectroscopies

et al. 2018

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“…According to studies by Koniakhin [24], these values of z-potential exhibit the evidence of the produced colloidal stability. Measures were taken in colloidal solutions before and after centrifugation.…”

Section: Resultsmentioning

confidence: 82%

Synthesis of CVD Diamond nanoparticles and Cytotoxicity evaluation in murine metastatic melanoma cells

Cc¹,

Cg²,

Falcao³

et al. 2020

Preprint

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Diamond nanoparticles (DNPs) have showed in vitro and in vivo biomedical applicability due to their low toxicity and biocompatibility. Recent studies have focused on the potential use of (DNPs) as suitable vehicles for improving drug delivery in cancer treatment. The advantages of DNPs lies in their high stability and small size compared to other carbon-based nanomaterials. In this work, CVD-diamond nanoparticles (CVD-DNPs) were synthesized and evaluated regarding their application as a new drug delivery platform for metastatic melanoma therapy. A new synthesis technique developed DNPs from CVD diamond thin film. This type of diamond has the same physical and chemical properties as a natural diamond: extreme hardness, excellent thermal conductivity, low coefficient of friction, biocompatibility, chemically inert for temperatures below 800 0 C, among others. The main objective of this study was to produce CVD-DNPs by laser ablation and to evaluate their cytotoxicity. A pulsed, ytterbium-doped fiber (Yb) was used to form DNPs in the pure aqueous medium (Milli-Q). The final suspension was obtained at high concentration of the CVD-DNPs and it was used to evaluate the cytotxicity in murine metastatic melanoma B16-F10 cells by using colorimetric assays. The characterization by FT-IR, X-Ray, DLS, RAMAN, SEM, and TEM demonstrated the successful synthesis of CVD-DNPs with a hydrodynamic diameter of 57 and 54 nm. In vitr o studies performed for 24h and 48h resulted in viability of 70-80% of cells incubated with CVD-DNPs at 250 μg/mL, which demonstrated a insignificant cytotoxic effect. Thus, these results suggest a potential use of CVD-DNPs as a drug delivery platform for antitumoral therapy.

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“…PEG-CNT composites were found to be hemocompatible, nontoxic to mice fibroblast cell lines and effective as a drug carrier (Hindumathi, Jagannatham, Haridoss, & Sharma, 2018). PEG was aided to produce ND with smaller particle size for harder centrifugation conditions (Koniakhin et al, 2018). For a similar reason, PEG was also used to coat antimicrobial nanoparticles (such as silver, zinc, etc.)…”

Section: Polyethylene Glycolmentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

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Ultracentrifugation for ultrafine nanodiamond fractionation

Cited by 20 publications

References 33 publications

Absorption spectra of nanodiamond aqueous dispersions by optical absorption and optoacoustic spectroscopies

Absorption spectra of nanodiamond aqueous dispersions by optical absorption and optoacoustic spectroscopies

Synthesis of CVD Diamond nanoparticles and Cytotoxicity evaluation in murine metastatic melanoma cells

Nanodiamond in composite: Biomedical application

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