Ultra-thin-polysiloxane-film-composite membranes for the optimisation of amperometric oxidase enzyme electrodes

Myler, Suzy; Collyer, Stuart D.; Bridge, Kerry; Higson, Séamus P.J.

doi:10.1016/s0956-5663(01)00265-2

Cited by 30 publications

(11 citation statements)

References 13 publications

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“…An electrochemical biosensor for the determination of blood glucose was constructed by the condensation polymerization of dimethyldichlorosilane at the surface of a porous alumina membrane [658]. Anodic porous alumina films can also be used as implants with enhanced bonebonding performance, by filling the nanopores with a bioactive material that supports normal osteoblastic activity [659].…”

Section: 57mentioning

confidence: 99%

Highly Ordered Anodic Porous Alumina Formation by Self‐Organized Anodizing

Sulka

2008

Nanostructured Materials in Electrochemistry

236

298

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Section: 57mentioning

confidence: 99%

Highly Ordered Anodic Porous Alumina Formation by Self‐Organized Anodizing

Sulka

2008

Nanostructured Materials in Electrochemistry

236

298

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“…[76,77] Moreover, such coatings are commonly applied to electrodes [77] by a photo-patterning process that involves complicated photolithography. [78] Besides the size, construction, and robustness issues, the traditional sensors are usually engineered to sense only one specific analyte or employ only one detection mode (either pH or humidity), and it is unclear whether they can be fabricated to be more diverse. Thus, these designs are typically "niche" sensors and are only useful if one specific type of response must be determined.…”

Section: Responsive Hybrid Structuresmentioning

confidence: 99%

Bimaterial Microcantilevers as a Hybrid Sensing Platform

et al. 2008

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Microcantilevers, one of the most common MEMS structures, have been introduced as a novel sensing paradigm nearly a decade ago. Ever since, the technology has emerged to find important applications in chemical, biological and physical sensing areas. Today the technology stands at the verge of providing the next generation of sophisticated sensors (such as artificial nose, artificial tongue) with extremely high sensitivity and miniature size. The article provides an overview of the modes of detection, theory behind the transduction mechanisms, materials employed as active layers, and some of the important applications. Emphasizing the material design aspects, the review underscores the most important findings, current trends, key challenges and future directions of the microcantilever based sensor technology.

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“…The main interferences come from the electrochemical oxidation of electroactive species, for example, ascorbic acid (AA), uric acid (UA) and 4-acetaminophen (4-AP). Traditional interference-removing methods include coating an additional selective or preoxidizing membrane on the front interface of the modified working electrode, [4][5][6] detecting glucose by means of a redox mediator, direct electron transfer between the enzyme and the electrodes, [7][8][9][10][11][12] and improving the electron-transfer turnover rate between the active site and the electrode. [11,12] Other interference-removing methods, such as enzyme microreactors, [13] bienzyme systems, [14] pre-electrolysis, [15] temperature variation, [16] and measuring cathodic current, [17,18] were also used to improve the selectivity of some electrochemical biosensors.…”

Section: Introductionmentioning

confidence: 99%

A Dual‐Electrode Approach for Highly Selective Detection of Glucose Based on Diffusion Layer Theory: Experiments and Simulation

Wang

Dai

Zhou

et al. 2005

Chemistry A European J

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A dual-electrode configuration for the highly selective detection of glucose in the diffusion layer of the substrate electrode is presented. In this approach, a glassy carbon electrode (GCE, substrate) modified with a conductive layer of glucose oxidase/Nafion/graphite (GNG) was used to create an interference-free region in its diffusion layer by electrochemical depletion of interfering electroactive species. A Pt microelectrode (tip, 5 microm in radius) was located in the diffusion layer of the GNG-modified GCE (GNG-G) with the help of scanning electrochemical microscopy. Consequently, the tip of the electrode could sense glucose selectively by detecting the amount of hydrogen peroxide (H2O2) formed from the oxidization of glucose on the glucose oxidase layer. The influences of parameters, including tip-substrate distance, substrate potential, and electrolyzing time, on the interference-removing efficiency of this dual-electrode approach have been investigated systematically. When the electrolyzing time was 30 s, the tip-substrate distance was 1.8 a (9.0 microm) (where a is the radius of the tip electrode), the potentials of the tip and substrate electrodes were 0.7 V and 0.4 V, respectively, and a mixture of ascorbic acid (0.3 mM), uric acid (0.3 mM), and 4-acetaminophen (0.3 mM) had no influence on the glucose detection. In addition, the current-time responses of the tip electrode at different tip-substrate distances in a solution containing interfering species were numerically simulated. The results from the simulation are in good agreement with the experimental data. This research provides a concept of detection in the diffusion layer of a substrate electrode, as an interference-free region, for developing novel microelectrochemical devices.

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Ultra-thin-polysiloxane-film-composite membranes for the optimisation of amperometric oxidase enzyme electrodes

Cited by 30 publications

References 13 publications

Highly Ordered Anodic Porous Alumina Formation by Self‐Organized Anodizing

Highly Ordered Anodic Porous Alumina Formation by Self‐Organized Anodizing

Bimaterial Microcantilevers as a Hybrid Sensing Platform

A Dual‐Electrode Approach for Highly Selective Detection of Glucose Based on Diffusion Layer Theory: Experiments and Simulation

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