Ultra-stiff and tough hydrogels based on small but strong hydrophobic associations <i>via</i> a low-reactive hydrophilic monomer

Lei, Yanqiang; Li, Shuo; Zhao, Zijian; Wang, Jie; Lv, Hongying; Yang, Xiaoniu

doi:10.1039/d3py00191a

Cited by 6 publications

(2 citation statements)

References 43 publications

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“…Under a load of 1 N, the average Hertz contact pressure is calculated to be ∼0.3 MPa. The average peak joint stresses range from 0.1 to 5.0 MPa, so the contact pressure used was within the physiological range. , After the 1000 reciprocating cycle test, the sample was measured using a three-dimensional (3D) optical profilometer.…”

Section: Experimental Sectionmentioning

confidence: 99%

Cartilage-Inspired, High-Strength, and Heat-Tolerant Lubricating Hydrogels by Macrophase Separation

Yang,

You,

Deng

et al. 2024

Biomacromolecules

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Hydrogels are considered as a potential cartilage replacement material based on their structure being similar to natural cartilage, which are of great significance in repairing cartilage defects. However, it is difficult for the existing hydrogels to combine the high load bearing and low friction properties (37 °C) of cartilage through sample methods. Herein, we report a facile and new fabrication strategy to construct the PNIPAm/EYL hydrogel by using the macrophase separation of supersaturated N-isopropylacrylamide (NIPAm) monomer solution to promote the formation of liposomes from egg yolk lecithin (EYL) and asymmetric template method. The PNIPAm/EYL hydrogels possess a relatively high compressive strength (more than 12 MPa), fracture energy (9820 J/m2), good fatigue resistance, lubricating properties, and excellent biocompatibility. Compared with the PNIPAm hydrogel, the friction coefficient (COF 0.046) of PNIPAm/EYL hydrogel is reduced by 50%. More importantly, the COF (0.056) of PNIPAm/EYL hydrogel above lower critical solution temperature (LCST) does not increase significantly, exhibiting heat-tolerant lubricity. The finite element analysis further proves that PNIPAm/EYL hydrogel can effectively disperse the applied stress and dissipate energy under load conditions. This work not only provides new insights for the design of high-strength lubricating hydrogels but also lays a foundation for the treatment of cartilage injury as a substitute material.

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Section: Experimental Sectionmentioning

confidence: 99%

Cartilage-Inspired, High-Strength, and Heat-Tolerant Lubricating Hydrogels by Macrophase Separation

Yang,

You,

Deng

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

show abstract

“…Hydrophobization is a process that involves the incorporation of hydrophobic species into the gel network, which assume roles as integral components of the structure or immobilized entities. [4][5][6][7][8][9][10][11][12][13] This integration can give rise to hydrophobic domains within the matrix of hydrogels. Thus, it not only bolsters the solubilization capacity for hydrophobic drugs but also profoundly influences the overall characteristics of the hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Tuning network structures of hydrophobic hydrogels by controlling polymerization solvent

Fan,

Naohara,

et al. 2024

Polym. Chem.

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A stiff and tough triple-shape memory hydrogel triggered at body temperature by hydrophobic association and electrostatic interaction

Yang,

Li,

Zhao

et al. 2024

Chemical Engineering Journal

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Ultra-stiff and tough hydrogels based on small but strong hydrophobic associations via a low-reactive hydrophilic monomer

Abstract: Synthetic hydrogels have made great progress in mechanical performance. But it is still a challenge to combine adequate stiffness, strength, and toughness in a single hydrogel. Herein, ultra-stiff, strong, and...

Cited by 6 publications

References 43 publications

Cartilage-Inspired, High-Strength, and Heat-Tolerant Lubricating Hydrogels by Macrophase Separation

Cartilage-Inspired, High-Strength, and Heat-Tolerant Lubricating Hydrogels by Macrophase Separation

Tuning network structures of hydrophobic hydrogels by controlling polymerization solvent

A stiff and tough triple-shape memory hydrogel triggered at body temperature by hydrophobic association and electrostatic interaction

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