Ultra-sonication-assisted silver nanoparticles using Panax ginseng root extract and their anti-cancer and antiviral activities

Sreekanth, T.V.M.; Nagajyothi, P.C.; Pandurangan, Muthuraman; Enkhtaivan, Gansukh; Vattikuti, S.V. Prabhakar; Tettey, Clement Okraku; Kim, Doo Hwan; Shim, Jaesool; Yoo, Kisoo

doi:10.1016/j.jphotobiol.2018.08.013

Cited by 119 publications

(52 citation statements)

References 45 publications

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“…The latest reports have shown that silver nanoparticles exhibit antiviral activities against influenza A virus, hepatitis B virus, human parainfluenza virus, herpes simplex virus, and human immunodeficiency virus [60]. Sreekanth et al have developed a simple and green ultra-sonication synthesis route for preparing quasi spherical silver nanoparticles with an aqueous extract from Panax ginseng roots, and the as-prepared silver nanoparticles were found to be viricidal against influenza A virus with excellent performance [61]. While AgNPs exhibit concentration-dependent cytotoxicity, their antiviral ability is not affected by the relatively low cytotoxicity.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

Chen

Liang

2020

Materials Science and Engineering: C

202

163

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Research on highly effective antiviral drugs is essential for preventing the spread of infections and reducing losses. Recently, many functional nanoparticles have been shown to possess remarkable antiviral ability, such as quantum dots, gold and silver nanoparticles, nanoclusters, carbon dots, graphene oxide, silicon materials, polymers and dendrimers. Despite their difference in antiviral mechanism and inhibition efficacy, these functional nanoparticles-based structures have unique features as potential antiviral candidates. In this topical review, we highlight the antiviral efficacy and mechanism of these nanoparticles. Specifically, we introduce various methods for analyzing the viricidal activity of functional nanoparticles and the latest advances in antiviral functional nanoparticles. Furthermore, we systematically describe the advantages and disadvantages of these functional nanoparticles in viricidal applications. Finally, we discuss the challenges and prospects of antiviral nanostructures. This topic review covers 132 papers and will enrich our knowledge about the antiviral efficacy and mechanism of various functional nanoparticles.

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Section: Silver Nanoparticlesmentioning

confidence: 99%

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

Chen

Liang

2020

Materials Science and Engineering: C

202

163

View full text Add to dashboard Cite

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“…Silver NPs synthesized with Panax ginseng root extract using the sonication method exhibited antiviral activity against the influenza A virus (strain A/PR/8) [150]. Low anti-influenza activity was identified at NP concentrations of 0.005, 0.01, and 0.15 M, with inhibitory rates of 5.31%, 4.18%, and 5.97%, respectively.…”

Section: Influenzamentioning

confidence: 99%

“…Low anti-influenza activity was identified at NP concentrations of 0.005, 0.01, and 0.15 M, with inhibitory rates of 5.31%, 4.18%, and 5.97%, respectively. However, the anti-influenza effects improved by 7.10% and 15.12%, with concentrations of 0.02 and 0.25 M, respectively [150]. Silver NPs with extracts from cinnamon (bark) demonstrated antiviral activity against the highly pathogenic avian influenza virus subtype H7N3.…”

Section: Influenzamentioning

confidence: 99%

Metal Nanoparticles: a Promising Treatment for Viral and Arboviral Infections

Maduray

Parboosing

2020

Biol Trace Elem Res

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Globally, viral diseases continue to pose a significant threat to public health. Recent outbreaks, such as influenza, coronavirus, Ebola, and dengue, have emphasized the urgent need for new antiviral therapeutics. Considerable efforts have focused on developing metal nanoparticles for the treatment of several pathogenic viruses. As a result of these efforts, metal nanoparticles are demonstrating promising antiviral activity against pathogenic surrogates and clinical isolates. This review summarizes the application of metal nanoparticles for the treatment of viral infections. It provides information on synthesis methods, size-related properties, nano-bio-interaction, and immunological effects of metal nanoparticles. This article also addresses critical criteria and considerations for developing clinically translatable nanosized metal particles to treat viral diseases.

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“…High power ultrasounds can break-down chemical bonds depolymerizing macromolecules, downsizing particles to nanoscale, making nanoemulsions, extracting bioactive substances from different matrices and so on, in research laboratories, in pharmaceutical and agrifood industries [40][41][42][43]. Sonochemistry was recently investigated for synthesis of bioactive nanostructures [44], different nanocarriers such as niosomes [45], liposomes [46], nanoemulsions [47], solid lipid nanoparticles [48], metal based systems [49], polymeric particles [50], nanoclusters [51] and nanocomposites [43]. Sonication processes were mainly performed to extract or degrade pesticides in order to support analysis and decontamination activities [52,53].…”

Section: Nanopesticides and Sonication Technologymentioning

confidence: 99%

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

Baldassarre

Tatulli²,

Vergaro

et al. 2020

Nanomaterials

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Recently, there is a growing demand in sustainable phytopathogens control research. Nanotechnology provides several tools such as new pesticides formulations, antibacterial nanomaterials and smart delivery systems. Metal nano-oxides and different biopolymers have been exploited in order to develop nanopesticides which can offer a targeted solution minimizing side effects on environment and human health. This work proposed a nanotechnological approach to obtain a new formulation of systemic fungicide fosetyl-Al employing ultrasonication assisted production of water dispersible nanocrystals. Moreover, chitosan was applicated as a coating agent aiming a synergistic antimicrobial effect between biopolymer and fungicide. Fosetyl-Al nanocrystals have been characterized by morphological and physical-chemical analysis. Nanotoxicological investigation was carried out on human keratinocytes cells through cells viability test and ultrastructural analysis. In vitro planktonic growth, biofilm production and agar dilution assays have been conducted on two Xylella fastidiosa subspecies. Fosetyl-Al nanocrystals resulted very stable over time and less toxic respect to conventional formulation. Finally, chitosan-based fosetyl-Al nanocrystals showed an interesting antibacterial activity against Xylella fastidiosa subsp. pauca and Xylella fastidiosa subsp. fastidiosa.

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Ultra-sonication-assisted silver nanoparticles using Panax ginseng root extract and their anti-cancer and antiviral activities

Cited by 119 publications

References 45 publications

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

Metal Nanoparticles: a Promising Treatment for Viral and Arboviral Infections

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

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