Ultra Performance Liquid Chromatography Method for Simultaneous Determination of Atovaquone and Proguanil in Rabbit Plasma and Its Application to a Pharmacokinetic Study

Veer, Vijay; Pingale, Satish G.; Mangaonkar, Kiran V.

doi:10.1080/10826076.2013.825854

Cited by 2 publications

(2 citation statements)

References 24 publications

(21 reference statements)

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“…In a typical SPE experiment, the analyte of interest is adsorbed onto the solid phase (and the original solvent is washed away) and then is eluted in a more concentrated and purified form. SPE is widely used in diverse fields ranging from pharmacokinetics and forensics, , to environmental and biological trace analysis, − and food analysis. , …”

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confidence: 99%

Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments

Lafrenière

Mudrik

et al. 2015

Anal. Chem.

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There is great interest in the development of integrated tools allowing for miniaturized sample processing, including solid phase extraction (SPE). We introduce a new format for microfluidic SPE relying on C18-functionalized magnetic beads that can be manipulated in droplets in a digital microfluidic platform. This format provides the opportunity to tune the amount (and potentially the type) of stationary phase on-the-fly, and allows the removal of beads after the extraction (to enable other operations in same device-space), maintaining device reconfigurability. Using the new method, we employed a design of experiments (DOE) operation to enable automated on-chip optimization of elution solvent composition for reversed phase SPE of a model system. Further, conditions were selected to enable on-chip fractionation of multiple analytes. Finally, the method was demonstrated to be useful for online cleanup of extracts from dried blood spot (DBS) samples. We anticipate this combination of features will prove useful for separating a wide range of analytes, from small molecules to peptides, from complex matrices.

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confidence: 99%

Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments

Lafrenière

Mudrik

et al. 2015

Anal. Chem.

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“…Few analytical methods using Spectrophotometry [9], HPLC [10][11][12] and LC-MS [13] have been reported for the simultaneous determination of Proguanil hydrochloride and Atovaquone in combined dosage forms. The objective of the present study was to develop and validate a simple, accurate and precise HPLC method for simultaneous determination of Proguanil and Atovaquone.…”

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confidence: 99%

Development and Validation for Simultaneous Estimation of Proguanil and Atovaquone by using RP-HPLC

Rao¹,

Prasanthi²,

Thunnisa³

2018

IJAT

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Ultra Performance Liquid Chromatography Method for Simultaneous Determination of Atovaquone and Proguanil in Rabbit Plasma and Its Application to a Pharmacokinetic Study

Cited by 2 publications

References 24 publications

Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments

Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments

Development and Validation for Simultaneous Estimation of Proguanil and Atovaquone by using RP-HPLC

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