Ultra-microsecond pulsed curcumin for effective treatment of triple negative breast cancers

Mittal, Lakshya; Raman, Vishak; Camarillo, Ignacio G.; Sundararajan, Raji

doi:10.1016/j.bbrc.2017.08.002

Cited by 21 publications

(10 citation statements)

References 13 publications

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“…Among many compounds tested, that is, doxorubicin, 36 ruthenium (III) compound, 37 5-fluorouracil, 38 phthalocyanines, 39 photofrin, 40 curcumin, 41 the trans-platinum analogue trans-[PtCl 2 (3-hmpy) 2 ], 42 oxaliplatin, 43 betulinic acid, 44,45 oat b-glucan, 46 cyanine IR-775, 47 catechin, 48 and sodium decahydrodecaborate, 49 only calcium electroporation was extensively studied. [50][51][52][53][54][55][56][57][58] Calcium electroporation effectively causes tumor necrosis, leaving the normal tissue less affected, making it a very promising compound for further clinical evaluation as it does not belong to the antineoplastic drugs, thus precautions related to antineoplastic drugs regarding storage, handling, disposal, and toxicity and mutagenicity are not an issue for calcium electroporation.…”

Section: Recent Advances In Electrochemotherapy 205mentioning

confidence: 99%

Recent Advances in Electrochemotherapy

Čemažar

Serša

2019

Bioelectricity

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Electrochemotherapy is gaining recognition as an effective local therapy that uses systemically or intratumorally injected bleomycin or cisplatin with electroporation as a delivery system that brings drugs into the cells to exert their cytotoxic effects. Preclinical work is still ongoing, testing new drugs, seeking the best treatment combination with other treatment modalities, and exploring new sets of pulses for effective tissue electroporation. The applications of electrochemotherapy are being fully exploited in veterinary oncology, where electrochemotherapy, because of its simple execution, has a relatively good cost-benefit ratio and is used in the treatment of cutaneous tumors. In human oncology, electrochemotherapy is fully recognized as a local therapy for cutaneous tumors and metastases. Its effectiveness is being explored in combination with immunomodulatory drugs. However, the development of electrochemotherapy is directed into the treatment of deepseated tumors with a percutaneous approach. Because of the vast number of reports, this review discusses the articles published in the past 5 years.

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Section: Recent Advances In Electrochemotherapy 205mentioning

confidence: 99%

Recent Advances in Electrochemotherapy

Čemažar

Serša

2019

Bioelectricity

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“…In addition, HER2 overexpressing tumors are more likely to be of grade 3 with TP53 mutations in 40-80% of the cases [38]. While previous studies report the cytotoxicity of individual curcuminoids [15,16,[39][40][41][42], here we studied the combined effect of the mixture of the three main curcuminoids-curcumin, desmethoxycurcumin, and bisdemethoxycurcumin, and their intracellular uptake in response to ECT in breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…The application of electrical pulses (EPs) with curcumin further enhances the anti-cancer action of curcumin using a phenomenon called electroporation [15,16]. Electroporation involves the application of short duration, high-intensity EP to accumulate charges on cell membrane.…”

Section: Introductionmentioning

confidence: 99%

The electrical pulse application enhances intra-cellular localization and potentiates cytotoxicity of curcumin in breast cancer cells

Bazzolo

Mittal

Sieni

et al. 2021

Bioelectrochemistry

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“…In conclusion, different from a recent electrochemotherapy study that applied high intensity electric current pulse to curcumin treatment [ 48 ], we here provide a novel approach by firstly using non-invasive PEF in combination with a low concentration of herbal agent to combat against pancreatic cancer. The results of the present study indicate the combination treatment could significantly suppress the migration of cancer cells and induce apoptosis through the mitochondria-dependent pathway.…”

Section: Discussionmentioning

confidence: 99%

Application of non-invasive low strength pulsed electric field to EGCG treatment synergistically enhanced the inhibition effect on PANC-1 cells

Hsieh

Chen

et al. 2017

PLoS ONE

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Traditional therapies for pancreatic cancer are usually expensive and likely to cause side effects, and most patients have the risk of recurrence and suffering pain. Here, we investigated combination treatment of epigallocatechin-3-gallate (EGCG) and non-invasive low strength pulsed electric field (PEF) on the human pancreatic cell line PANC-1. Cells were cultured in various concentrations of EGCG and exposed to trains of PEF. The results showed that the low strength PEF alone or single treatment with low concentration of EGCG did not obviously affect the cell proliferation and migration in PANC-1. However, the EGCG-induced inhibitions of cell viability and migration ability in PANC-1 were dramatically enhanced by the further exposure of low strength PEF (60 V/cm). In particular, the same combination treatment caused less inhibition of cell viability in non-malignant HEK293 cells. We also found the combination treatment significantly decreased the ratio of Bcl-2/Bax protein and increased caspase activity in PANC-1 cells, resulting in the promotion of apoptotic responses, evidenced by chromatin condensation. The findings of the present study reveal the synergistic reactions in the combination treatment may severely disturb mitochondria, enhance the intrinsic pathway transduction, and effectively induce apoptosis; moreover, the migration and invasion of PANC-1 cancer cells were also significantly suppressed. Since normal cells are less sensitive to this combination treatment, and the non-invasive PEF could be modified to focus on a specific location, this treatment may serve as a promising method for anti-cancer therapy.

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Ultra-microsecond pulsed curcumin for effective treatment of triple negative breast cancers

Cited by 21 publications

References 13 publications

Recent Advances in Electrochemotherapy

Recent Advances in Electrochemotherapy

The electrical pulse application enhances intra-cellular localization and potentiates cytotoxicity of curcumin in breast cancer cells

Application of non-invasive low strength pulsed electric field to EGCG treatment synergistically enhanced the inhibition effect on PANC-1 cells

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