Ultra-High-Sensitivity Submillimeter Mouse SPECT

Ivashchenko, Oleksandra; Have, Frans van der; Goorden, Marlies C; Ramakers, Ruud M.; Beekman, Freek J.

doi:10.2967/jnumed.114.147140

Cited by 43 publications

(75 citation statements)

References 20 publications

(19 reference statements)

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“…Moreover the distance from the source to the collimator is chosen relatively small, to achieve a large magnification. In some cases researchers have even used an 'inverted' single knife edge collimator (which diverges from a narrow opening near the source to a wider opening near the detector), to make the distance to the source even smaller [5]. From a qualitative understanding of the physical principles -as discussed in section 6 -it seems likely that the differences that we have observed between one dimensional SKE and DKE collimators, will also occur for cylindrical collimators, with a 3D conical opening.…”

Section: Results For Cylindrical Collimatorsmentioning

confidence: 99%

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Optimal Shape of a Gamma-ray Collimator: single vs double knife edge

Metz

Hogenbirk

2017

EPJ Web Conf.

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Abstract. Gamma-ray collimators in nuclear waste scanners are used for selecting a narrow vertical segment in activity measurements of waste vessels. The system that is used by NRG uses tapered slit collimators of both the single and double knife edge type. The properties of these collimators were investigated by means of Monte Carlo simulations. We found that single knife edge collimators are highly preferable for a conservative estimate of the activity of the waste vessels. These collimators show much less dependence on the angle of incidence of the radiation than double knife edge collimators. This conclusion also applies to cylindrical collimators of the single knife edge type, that are generally used in medical imaging spectroscopy.

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Section: Results For Cylindrical Collimatorsmentioning

confidence: 99%

“…Because reversed cylindrical SKE collimators are occasionally used in imaging studies [5], these were also investigated. In a reversed SKE collimator, the conical opening diverges towards the detector.…”

Section: Reversed Cylindrical Collimatorsmentioning

confidence: 99%

Optimal Shape of a Gamma-ray Collimator: single vs double knife edge

Metz

Hogenbirk

2017

EPJ Web Conf.

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“…However, detection sensitivity of SPECT and SPECT/CT cameras is generally low, requiring the injection of high activities or long scan duration. On the other hand, the resolution of micro-PET/CT systems is intrinsically limited to the range of 1–2 mm by the positron path length in tissue and by the non-collinearity of positron-electron annihilation; however, due to the lack of collimation, detection sensitivity is in general much higher with PET/CT than with SPECT/CT (5–8). …”

Section: Measurement Of Cardiac Functionmentioning

confidence: 99%

Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play

et al. 2017

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The interest around small-animal cardiac radionuclide imaging is growing as rodent models can be manipulated to allow the simulation of human diseases. In addition to new radiopharmaceuticals testing, often researchers apply well-established probes to animal models, to follow the evolution of the target disease. This reverse translation of standard radiopharmaceuticals to rodent models is complicated by technical shortcomings and by obvious differences between human and rodent cardiac physiology. In addition, radionuclide studies involving small animals are affected by several extrinsic variables, such as the choice of anesthetic. In this paper, we review the major cardiac features that can be studied with classical single-photon and positron-emitting radiopharmaceuticals, namely, cardiac function, perfusion and metabolism, as well as the results and pitfalls of small-animal radionuclide imaging techniques. In addition, we provide a concise guide to the understanding of the most frequently used anesthetics such as ketamine/xylazine, isoflurane, and pentobarbital. We address in particular their mechanisms of action and the potential effects on radionuclide imaging. Indeed, cardiac function, perfusion, and metabolism can all be significantly affected by varying anesthetics and animal handling conditions.

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“…Moreover, this allows the region of interest to be measured very precisely, which helps with focused imaging [5][6][7][8][9][10]. In contrast to conventional systems operating three detectors, the novel fifth-generation U-SPECT system tested in this study uses a two-detector set-up without the bottom detector.…”

Section: Introductionmentioning

confidence: 99%

Performance Evaluation of Fifth-generation Ultra-high-resolution Spect System With Two Stationary Detectors and Multi-pinhole Imaging

Hoffmann

Janssen

Kuriyama

et al. 2020

Preprint

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Purpose Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector-configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+). Methods The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Results Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. Resolution in the visually analysed sections of the reconstructed hot-rod phantom was 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M). Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60–1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR. Conclusions While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.

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Ultra-High-Sensitivity Submillimeter Mouse SPECT

Abstract: The high sensitivity achieved increases the range of mouse SPECT applications by enabling in vivo imaging with less than a megabecquerel of tracer activity or down to 1-s frame dynamics.

Cited by 43 publications

References 20 publications

Optimal Shape of a Gamma-ray Collimator: single vs double knife edge

Optimal Shape of a Gamma-ray Collimator: single vs double knife edge

Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play

Performance Evaluation of Fifth-generation Ultra-high-resolution Spect System With Two Stationary Detectors and Multi-pinhole Imaging

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