Ultra-high sensitivity cardiac troponin-I concentration and left ventricular structure and function in women with ischemia and no obstructive coronary artery disease

Quesada, Odayme; Elboudwarej, Omeed; Nelson, Michael D.; AlBadri, Ahmed; Mastali, Mitra; Wei, Janet; Zarrabi, Bijan; Suppogu, Nissi; Aldiwani, Haider; Mehta, Puja K.; Shufelt, Chrisandra; Berman, Daniel S.; Thomson, Louise; Handberg, Eileen; Pepine, Carl J.; Eyk, Jennifer E. Van; Merz, C. Noel Bairey

doi:10.1016/j.ahjo.2022.100115

Cited by 2 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…WISE found ultra-high-sensitivity cardiac troponin I (u-hsc-TnI) levels were significantly elevated in women with coronary endothelial dysfunction diagnosed by invasive coronary function testing [ 80 ]. Subsequent WISE analysis of 327 women with INOCA determined that higher u-hscTnI levels were associated with higher LV mass index and strain measures of LV diastolic and LV systolic dysfunction [ 81 ], expanding prior reports linking hs-cTnI with echocardiographic measures of LV diastolic dysfunction and heart failure hospitalizations in patients with suspected INOCA [ 13 ]. These data suggest that cardiomyocyte injury is the underlying mechanism of LV systolic and diastolic dysfunction in patients with INOCA, supporting the link between CMD-related ischemia, cardiomyocyte injury, LV diastolic dysfunction, and subsequent heart failure hospitalization.…”

Section: Pre-hfpef Characteristics In Women With Inocamentioning

confidence: 99%

Latest from the WISE: Contributions to the Understanding of Ischemia and Heart Failure among Women with No Obstructive Coronary Arteries

Hansen¹,

Nelson²,

Handberg³

et al. 2023

Rev. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

Since 1996, the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) has been investigating pathophysiological processes underlying ischemic heart disease in women and related outcomes. Recent findings have focused on women with signs and symptoms of ischemia and no obstructive coronary arteries (INOCA) and their elevated risk for heart failure with preserved ejection fraction (HFpEF). This review summarizes the latest WISE findings related to INOCA and pre-HFpEF characteristics, addressing our understanding of contributions from traditional vs nontraditional risk factors in women.

show abstract

Section: Pre-hfpef Characteristics In Women With Inocamentioning

confidence: 99%