Ultra-high-resolution ion mobility spectrometry—current instrumentation, limitations, and future developments

Kirk, Ansgar T.; Bohnhorst, Alexander; Raddatz, Christian-Robert; Allers, Maria; Zimmermann, Stefan

doi:10.1007/s00216-019-01807-0

Cited by 77 publications

(103 citation statements)

References 180 publications

(232 reference statements)

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“…The Flex-DT is capable of achieving a resolution metric in excess of 80, which places it into the category of high resolution. 17 This result is even more significant given the ease of assembly and cost to manufacture, which is a fraction of that required for a traditional DT design. This is a key building block toward future research endeavors, such as the establishment of a low-cost, portable and power-efficient IMS system suitable for high volume manufacture, to enable off-the-shelf analytical instrumentation for Internet of Things (IoT) measurements with high-speed connectivity for cloud-based data analytics.…”

Section: Discussionmentioning

confidence: 99%

Flexible Drift Tube for High Resolution Ion Mobility Spectrometry (Flex-DT-IMS)

et al. 2020

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This paper describes, in detail, the development of a novel, low-cost, and flexible drift tube (DT) along with an associated ion mobility spectrometer system. The DT is constructed from a flexible printed circuit board (PCB), with a bespoke “dog-leg” track design, that can be rolled up for ease of assembly. This approach incorporates a shielding layer, as part of the flexible PCB design, and represents the minimum dimensional footprint conceivable for a DT. The low thermal mass of the polyimide substrate and overlapping electrodes, as afforded by the dog-leg design, allow for efficient heat management and high field linearity within the tube–achieved from a single PCB. This is further enhanced by a novel double-glazing configuration which provides a simple and effective means for gas management, minimizing thermal variation within the assembly. Herein, we provide a full experimental characterization of the flexible DT ion mobility spectrometer (Flex-DT-IMS) with corresponding electrodynamic (Simion 8.1) and fluid dynamic (SolidWorks) simulations. The Flex-DT-IMS is shown to have a resolution >80 and a detection limit of low nanograms for the analysis of common explosives (RDX, PETN, HMX, and TNT).

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Section: Discussionmentioning

confidence: 99%

Flexible Drift Tube for High Resolution Ion Mobility Spectrometry (Flex-DT-IMS)

et al. 2020

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“…Voltage waves move faster than the ions, so they roll over the wave and require a succession of them to reach the exit of the mobility cell. In addition, in order to prevent the ions being pushed towards the drift tube wall, radio-frequency (RF) voltages of opposite phases are periodically applied to adjacent electrodes causing the radial confinement of ions [4,23].…”

Section: Overview Of Ion Mobility Spectrometry (Ims) Technique Andmentioning

confidence: 99%

“…However, commercial systems are not able to routinely offer this type of performance. TIMS is the only capable to provide a R p higher than 200 [41], which is considered the lower limit of ultra-high resolution (UHR)IMS [23]. R p of DTIMS systems is around 100 whereas TWIMS instruments currently reach a maximum R p of 40 [14,23].…”

Section: Current Perspectives Of Ion Mobility Spectrometrymentioning

confidence: 99%

“…TIMS is the only capable to provide a R p higher than 200 [41], which is considered the lower limit of ultra-high resolution (UHR)IMS [23]. R p of DTIMS systems is around 100 whereas TWIMS instruments currently reach a maximum R p of 40 [14,23]. Therefore, the development of UHRIMS and its implementation in routine analysis obviously represent some of the main challenges of IMS, but it will also contribute to extend the use of this technique.…”

Section: Current Perspectives Of Ion Mobility Spectrometrymentioning

confidence: 99%

“…As a result of the improvements on R p expected in UHRIMS technology, IMS separations will be able to provide similar peak capacities as LC at lower analysis times, which will be revolutionary from an analytical point of view and transformative for several applications [121]. In general, limitations on the applied field involve that R p can only be increased by extending the drift path, although it presents some practical constraints [17,23]. In this sense, two IMS approaches (i.e., cyclic-TWIMS and structure for lossless ion manipulations (SLIM)–TWIMS) have successfully overcome these drawbacks and, consequently, are gaining attention due to their enhanced R p .…”

Section: Current Perspectives Of Ion Mobility Spectrometrymentioning

confidence: 99%

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Ion Mobility Spectrometry in Food Analysis: Principles, Current Applications and Future Trends

et al. 2019

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In the last decade, ion mobility spectrometry (IMS) has reemerged as an analytical separation technique, especially due to the commercialization of ion mobility mass spectrometers. Its applicability has been extended beyond classical applications such as the determination of chemical warfare agents and nowadays it is widely used for the characterization of biomolecules (e.g., proteins, glycans, lipids, etc.) and, more recently, of small molecules (e.g., metabolites, xenobiotics, etc.). Following this trend, the interest in this technique is growing among researchers from different fields including food science. Several advantages are attributed to IMS when integrated in traditional liquid chromatography (LC) and gas chromatography (GC) mass spectrometry (MS) workflows: (1) it improves method selectivity by providing an additional separation dimension that allows the separation of isobaric and isomeric compounds; (2) it increases method sensitivity by isolating the compounds of interest from background noise; (3) and it provides complementary information to mass spectra and retention time, the so-called collision cross section (CCS), so compounds can be identified with more confidence, either in targeted or non-targeted approaches. In this context, the number of applications focused on food analysis has increased exponentially in the last few years. This review provides an overview of the current status of IMS technology and its applicability in different areas of food analysis (i.e., food composition, process control, authentication, adulteration and safety).

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Lipid Analysis by Mass Spectrometry coupled with Laser Light

Kirschbaum

Pagel

2022

Analysis & Sensing

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Lipids are small but complex biomolecules that feature an immense structural and functional diversity. The molecular structure and biological functions of lipids are intricately linked. Therefore, modern lipid analysis strives for complete structural elucidation and spatial mapping of individual species in tissues. Mass spectrometry is the uncontested key technology in lipidomics but cannot achieve this goal as a standalone technique. In particular, the distinction between frequently occurring isomers constitutes a major challenge. A promising step towards complete structural analysis of lipids consists in the coupling of mass spectrometry with laser light. Here we review recent advances in lipidomics applications employing laser‐induced ultraviolet and infrared photodissociation and ion spectroscopy, which substantially increase the gain in structural information. Fundamental concepts, instrumentation and promises of these powerful emerging techniques for future lipid analysis are outlined.

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Ultra-high-resolution ion mobility spectrometry—current instrumentation, limitations, and future developments

Cited by 77 publications

References 180 publications

Flexible Drift Tube for High Resolution Ion Mobility Spectrometry (Flex-DT-IMS)

Flexible Drift Tube for High Resolution Ion Mobility Spectrometry (Flex-DT-IMS)

Ion Mobility Spectrometry in Food Analysis: Principles, Current Applications and Future Trends

Lipid Analysis by Mass Spectrometry coupled with Laser Light

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