Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Diagnosis and Management of Ocular Surface Squamous Neoplasia

Thomas, Benjamin; Galor, Anat; Nanji, Afshan; Sayyad, Fouad E.; Wang, Jianhua; Dubovy, Sander R.; Joag, Madhura; Karp, Carol L.

doi:10.1016/j.jtos.2013.11.001

Cited by 156 publications

(148 citation statements)

References 71 publications

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“…The iVue-100 SD-OCT (Optovue Inc. Fremont, CA, USA) device was used to measure CCT and RNFL thickness. The iVue-100 SD-OCT scans faster (26,000 A-scans per second) and provides higher resolution cross-sectional images (5 µm) than the TD-OCT. 5,6,7,8 RNFL measurements were performed using the optic nerve head (ONH) iVue-100 (Optovue, Inc.) protocol, which consists of 12 radial scans 3.4 mm in length and 13 concentric ring scans ranging from 1.3 to 4.9 mm. RNFL thickness was measured along a circle of 3.45 mm diameter centred on the optic disc, with the outputs from the measurements being temporal, superior, nasal, and inferior average.…”

Section: Methodsmentioning

confidence: 99%

“…5 The recently developed spectral domain (SD-OCT) technology 5 has a five times higher image resolution and 60 times faster imaging speed compared with the conventional time domain (TD-OCT) devices, resulting in improved diagnostic accuracy in detecting early glaucoma. 6,7,8 Normative databases of RNFL thickness values from age-matched normals are used to interpret thickness measurements generated by SD-OCT machines. These values vary and cannot be used interchangeably between different SD-OCT machines.…”

Section: Introductionmentioning

confidence: 99%

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Retinal nerve fibre layer thickness values and their associations with ocular and systemic parameters in Black South Africans

Mashige¹,

Oduntan²

2017

Afr H. Sci.

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Purpose: To measure the retinal nerve fibre layer (RNFL) thickness values and investigate their associations with other parameters in healthy eyes of Black South Africans. Methods: 600 participants with healthy eyes, of whom 305 (50.83%) were males and 295 (49.17%) were females, with a mean age of 28.15 ± 13.09 years, underwent a detailed ophthalmic examination. RNFL thickness was measured by iVue SD-OCT. Results: The mean global RNFL thickness was 110.01 ± 7.39 μm. The RNFL was thickest inferiorly (135.06 ± 9.66 µm) and superiorly (131.72 ± 10.46 µm), thinner nasally (87.24 ± 13.22 µm), and thinnest temporally (73.63 ± 15.66 µm). Multivariate analysis showed that thicker mean global RNFL thickness was significantly associated with younger age, shorter axial length (AL) and hyperopia (p < 0.001). Mean RNFL thickness decreased by approximately 0.11 µm per year of aging life, and by 1.02 µm for each 1-mm of axial elongation. There was a 0.62 µm RNFL thickness increase for every dioptre change in spherical power towards more hyperopia. Conclusion: Mean RNFL thickness values and their associations established in this population may be of clinical value when assessing factors that influence this parameter and diagnosing diseases affecting it.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retinal nerve fibre layer thickness values and their associations with ocular and systemic parameters in Black South Africans

Mashige¹,

Oduntan²

2017

Afr H. Sci.

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“…Due to the multifocal nature of OSSN, surgical excision results in extensive collateral damage to adjacent areas of normal epithelium (37) . In addition to IC, newer diagnostic techniques including CCM (22) , toluidine blue (38) , and ultra-high resolution anterior segment optical coherence tomography (UHR-OCT) (39) have been reported to aid in the diagnosis of OSSN. All these techniques have limitations and require skilled professionals to perform the tests and interpret the results.…”

Section: Ic Imaging and Histopathologymentioning

confidence: 99%

“…Despite UHR-OCT having the advantage over IC of providing relatively deeper scans of the entire epithelium and the underlying tissue, it cannot reliably detect invasion (37) . In addition, UHR-OCT machines are largely limited to academic institutions (39) . IC may be an inexpensive tool that can be used in the outpatient clinic setting to help provide an objective evaluation of suspicious lesions that enables patients to make better informed decisions regarding the treatment requirements.…”

Section: Ic Imaging and Histopathologymentioning

confidence: 99%

Impression cytology in the evaluation of ocular surface tumors: review article

Barros¹,

Almeida²,

Lowen³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Impression cytology (IC) has been widely used as a method for evaluating the ocular surface and superficial cells layers in the diagnosis and follow-up after treatment of several ocular surface tumors of both epithelial and melanocytic origin. Information regarding this can be found in the English-language literature since 1992. Using either cellulose acetate or Biopore membranes for specimen collection, a high correlation has been found between IC and tissue histology. Compared with exfoliative cytology with spatula, IC is less traumatic to the patient's eye, provides a precise location of the area being studied, and allows accurate observation of the cells the way they exist in vivo. The additional advantage of IC is the preservation of limbal stem cells responsible for continuous corneal epithelium renewal; these can be affected after incisional or excisional biopsy at the corneoscleral limbus, which is the most frequent site of appearance of tumors in the stratified epithelium. Treatment for ocular surface squamous neoplasia has historically included surgery, but nonsurgical interventions have also been adopted. Hence, in certain cases, ophthalmologists may prefer interventions less invasive than surgical biopsy such as of impression cytology for both initial diagnosis and therapeutic monitoring of treatment for ocular surface lesions. Nevertheless, it should be considered that IC may be less helpful if the results conflict with the clinical picture or if the clinical diagnosis is uncertain and results are negative. In such cases, surgical biopsy is required for accurate diagnosis. The purpose of this review is to examine the published literature on the utilization of IC for the diagnosis and management of ocular surface tumors and to discuss the requirement for further investigation on the subject.

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“…We used a custom-built spectral domain anterior segment UHR OCT which has a center wavelength of 840 nm, allowing for imaging with an axial resolution of approximately 3 μm [5]. UHR OCT showed marked thickening of the corneal epithelium in the area of the lesion, which is suggestive of proliferating epithelium seen in epithelial tumors such as corneal intraepithelial neoplasia and CIN [5,6]. In addition, the lesion was dense and irregular, causing shadowing posterior to the lesion (fig.…”

Section: Case Reportmentioning

confidence: 99%

Conjunctival Intraepithelial Neoplasia with Mucoepidermoid Differentiation: A Case Report of a Subtle Lesion

Joag¹,

Gupta²,

Dubovy³

et al. 2015

Ocul Oncol Pathol

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Objective: To describe the clinical presentation, diagnostic imaging, and treatment options of conjunctival intraepithelial neoplasia (CIN) with mucoepidermoid differentiation, an in situ stage of mucoepidermoid carcinoma of the conjunctiva (MCC). Results: We report the case of an 86-year-old man presenting with a subtle limbal lesion that had only mild erythema and elevation. Based on a few atypical clinical features and an abnormal ultrahigh-resolution optical coherence tomography (UHR OCT), an incisional biopsy was performed revealing CIN with mucoepidermoid differentiation. Treatment involved aggressive surgical excision. No evidence of recurrence was noted in the 5 years of follow-up. Conclusion: MCC is an aggressive tumor that has a tendency to be invasive and recur after treatment. Therefore, early diagnosis and treatment is critical. CIN with mucoepidermoid differentiation may represent the earliest stage of MCC. It can present subtly, with a clinical resemblance to benign and less aggressive ocular surface lesions. Imaging with UHR OCT may be helpful to detect early neoplasia. A high level of suspicion must be maintained when evaluating potential ocular surface tumors.

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Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Diagnosis and Management of Ocular Surface Squamous Neoplasia

Cited by 156 publications

References 71 publications

Retinal nerve fibre layer thickness values and their associations with ocular and systemic parameters in Black South Africans

Retinal nerve fibre layer thickness values and their associations with ocular and systemic parameters in Black South Africans

Impression cytology in the evaluation of ocular surface tumors: review article

Conjunctival Intraepithelial Neoplasia with Mucoepidermoid Differentiation: A Case Report of a Subtle Lesion

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