Ultra-high-performance liquid chromatography supports a new reaction mechanism between free radicals and ferulic acid with antimicrobial and antioxidant activities

Berton, Sharise B.R.; Cabral, Márcia Regina Pereira; Jesus, Guilherme Augusto Moraes de; Sarragiotto, María Helena; Pilau, Eduardo Jorge; Martins, Alessandro F.; Bonafé, Elton Guntendorfer; Matsushita, Makoto

doi:10.1016/j.indcrop.2020.112701

Cited by 20 publications

(11 citation statements)

References 81 publications

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“…3,4-Dihydroxy benzoic acid is considered to have good antioxidant activities [27] , [23] , [47] . Further, benzoic acid, ferulic acid and p-coumaric acid are reported to possess strong antioxidant and antimicrobial activities [10] , [26] , [45] , [55] . The finding of this study confirms that presence of several phenolic compounds in DSNPs that have high antioxidant and antimicrobial activities.…”

Section: Resultsmentioning

confidence: 99%

A novel strategy for producing nano-particles from date seeds and enhancing their phenolic content and antioxidant properties using ultrasound-assisted extraction: A multivariate based optimization study

Mostafa

Airouyuwa

Maqsood

2022

Ultrasonics Sonochemistry

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Section: Resultsmentioning

confidence: 99%

A novel strategy for producing nano-particles from date seeds and enhancing their phenolic content and antioxidant properties using ultrasound-assisted extraction: A multivariate based optimization study

Mostafa

Airouyuwa

Maqsood

2022

Ultrasonics Sonochemistry

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“…Meanwhile, FA has strong antioxidant properties and can scavenge H 2 O 2 , hydroxyl radicals, O 2 - , and peroxynitrite very well. It also has a physiological modulating effect, not only inhibiting free radical-producing enzymes but also increasing the activity of free radical-eliminating enzymes ( Mathew and Abraham, 2004 ; Berton et al., 2020 ). Lignin is the second most abundant secondary metabolite in nature following cellulose and important structural material in plant cell wall formation, which has important biological functions for the plant body and can improve plant resistance against biotic and abiotic stresses ( Chen et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Integrated metabolomic and transcriptomic analysis reveals the role of phenylpropanoid biosynthesis pathway in tomato roots during salt stress

et al. 2022

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As global soil salinization continues to intensify, there is a need to enhance salt tolerance in crops. Understanding the molecular mechanisms of tomato (Solanum lycopersicum) roots’ adaptation to salt stress is of great significance to enhance its salt tolerance and promote its planting in saline soils. A combined analysis of the metabolome and transcriptome of S. lycopersicum roots under different periods of salt stress according to changes in phenotypic and root physiological indices revealed that different accumulated metabolites and differentially expressed genes (DEGs) associated with phenylpropanoid biosynthesis were significantly altered. The levels of phenylpropanoids increased and showed a dynamic trend with the duration of salt stress. Ferulic acid (FA) and spermidine (Spd) levels were substantially up-regulated at the initial and mid-late stages of salt stress, respectively, and were significantly correlated with the expression of the corresponding synthetic genes. The results of canonical correlation analysis screening of highly correlated DEGs and construction of regulatory relationship networks with transcription factors (TFs) for FA and Spd, respectively, showed that the obtained target genes were regulated by most of the TFs, and TFs such as MYB, Dof, BPC, GRAS, and AP2/ERF might contribute to the regulation of FA and Spd content levels. Ultimately, FA and Spd attenuated the harm caused by salt stress in S. lycopersicum, and they may be key regulators of its salt tolerance. These findings uncover the dynamics and possible molecular mechanisms of phenylpropanoids during different salt stress periods, providing a basis for future studies and crop improvement.

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“…Ferulic acid plays an important role in the human body and is absorbed in the small intestine as a major metabolite of chlorogenic acids [ 12 , 13 ]. FA is known for its powerful antioxidant effect, being useful in the elimination of free radicals [ 14 ]. Additionally, it has a good pain-killing effect, and is suggested as an aid in treating neuropathic pain [ 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Novel Electrochemical Biosensor Based on Carbon Nanofibers–Gold Nanoparticles–Tyrosinase for the Detection of Ferulic Acid in Cosmetics

Bounegru

Apetrei

2020

Sensors

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The present paper deals with the electrochemical behavior of three types of sensors based on modified screen-printed electrodes (SPEs): a sensor based on carbon nanofibers (CNF/SPE), a sensor based on nanofibers of carbon modified with gold nanoparticles (CNF-GNP/SPE) and a biosensor based on nanofibers of carbon modified with gold nanoparticles and tyrosinase (CNF-GNP-Ty/SPE). To prepare the biosensor, the tyrosinase (Ty) was immobilized on the surface of the electrode already modified with carbon nanofibers and gold nanoparticles, by the drop-and-dry technique. The electrochemical properties of the three electrodes were studied by cyclic voltammetry in electroactive solutions, and the position and shape of the active redox peaks are according to the nature of the materials modifying the electrodes. In the case of ferulic acid, a series of characteristic peaks were observed, the processes being more intense for the biosensor, with the higher sensitivity and selectivity being due to the immobilization of tyrosinase, a specific enzyme for phenolic compounds. The calibration curve was subsequently created using CNF-GNP-Ty/SPE in ferulic acid solutions of various concentrations in the range 0.1–129.6 μM. This new biosensor allowed low values of the detection threshold and quantification limit, 2.89 × 10−9 mol·L−1 and 9.64 × 10−9 mol·L−1, respectively, which shows that the electroanalytical method is feasible for quantifying ferulic acid in real samples. The ferulic acid was quantitatively determined in three cosmetic products by means of the CNF-GNP-Ty/SPE biosensor. The results obtained were validated by means of the spectrometric method in the infrared range, the differences between the values of the ferulic acid concentrations obtained by the two methods being under 5%.

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Ultra-high-performance liquid chromatography supports a new reaction mechanism between free radicals and ferulic acid with antimicrobial and antioxidant activities

Cited by 20 publications

References 81 publications

A novel strategy for producing nano-particles from date seeds and enhancing their phenolic content and antioxidant properties using ultrasound-assisted extraction: A multivariate based optimization study

A novel strategy for producing nano-particles from date seeds and enhancing their phenolic content and antioxidant properties using ultrasound-assisted extraction: A multivariate based optimization study

Integrated metabolomic and transcriptomic analysis reveals the role of phenylpropanoid biosynthesis pathway in tomato roots during salt stress

Development of a Novel Electrochemical Biosensor Based on Carbon Nanofibers–Gold Nanoparticles–Tyrosinase for the Detection of Ferulic Acid in Cosmetics

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