2009
DOI: 10.1016/j.jchromb.2009.05.052
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Ultra high performance liquid chromatography tandem mass spectrometric detection in clinical analysis of simvastatin and atorvastatin

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Cited by 57 publications
(53 citation statements)
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“…The optimization of conditioning and washing solution composition, pH for conditioning and washing step and elution solvent selection were described in details. The SPE procedure has also been used as sample preparation step for quantification of atorvastatin and simvastatin as well as their metabolites in serum from patients with end stage renal disease [83]. In order to obtain the satisfactory and repeatable extraction efficacy and to remove matrix effects, several different reversed-phase SPE sorbents have been tested.…”
Section: Sample Preparationmentioning
confidence: 99%
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“…The optimization of conditioning and washing solution composition, pH for conditioning and washing step and elution solvent selection were described in details. The SPE procedure has also been used as sample preparation step for quantification of atorvastatin and simvastatin as well as their metabolites in serum from patients with end stage renal disease [83]. In order to obtain the satisfactory and repeatable extraction efficacy and to remove matrix effects, several different reversed-phase SPE sorbents have been tested.…”
Section: Sample Preparationmentioning
confidence: 99%
“…Briefly, MEPS is a miniaturization of conventional SPE, but it differs from commercial SPE by fact that packing is inserted directly into the syringe, not into a separate column. In addition, they have compared a previously described [83] SPE procedure for extraction of atorvastatin and its metabolites from human serum with newly developed MEPS approach. The results of samples treated by SPE and MEPS were compared by means of Student t-test.…”
Section: Sample Preparationmentioning
confidence: 99%
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“…ATV-FX1 (4-(1b-4-floro-fenil)-6-hidroksi-6-isopropil-1a-fenil-6a-fenilkarbomoil-hekzahidro-1,2-dioksa-5a-aza-siklopropa(a)inden-3-il-3-(R)-hidroksibutirik asit) atorvastatinin alkali asetonitrilli çözeltisinin içine hidrojen peroksit ilavesiyle hazırlanmıştır. Güneş ışığında birkaç saat atorvastatinin sulu asetonitrilli çözeltisinin pH:8- ise atorvastatinin biyolojik sıvılarda miktar tayini için bir UPLC/MS metodu geliştirilmiştir (12 Literatürlerde atorvastatinin miktar tayini ve safsızlıkla-rının analizleri için kromatografik ayırım genellikle tampon çözeltilerinin kullanıldığı gradient bir metot kullanılarak sağlanmıştır. Bu çalışmada, diklofenak sodyum internal standart olarak kullanılarak isokratik bir ayırım ile atorvastatin kalsiyumun analizinin yapılması amaçlanmıştır.…”
Section: Introductionunclassified