Ultra-high field 7 T imaging in multiple sclerosis

Louapre, Céline; Treabă, Constantina Andrada; Barletta, Valeria; Mainero, Caterina

doi:10.1097/wco.0000000000000839

Cited by 8 publications

(5 citation statements)

References 75 publications

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“…Other 7T SWI reports exist of visualization of vascular anomalies such as cavernous malformations with associated developmental venous anomalies, 29,30 radiation-induced microbleeds, [31][32][33] iron deposition in multiple sclerosis lesions, [34][35][36] substantia nigra in Parkinson disease, 37 other degenerative diseases, 38 and senile plaquelike lesions in patients with Alzheimer disease. 14 In the present study, we found that the same postprocessing methods were optimal for visualization of the corticomedullary junction and the small vasculature of gliomas.…”

Section: Application Of 7t Swi In Assessment Of Brain Tumors and Othe...mentioning

confidence: 99%

SWI by 7T MR Imaging for the Microscopic Imaging Diagnosis of Astrocytic and Oligodendroglial Tumors

Natsumeda¹,

Matsuzawa²,

Watanabe³

et al. 2022

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Despite advances in molecular imaging, preoperative diagnosis of astrocytomas and oligodendrogliomas can be challenging. In the present study, we assessed whether 7T SWI can be used to distinguish astrocytomas and oligodendrogliomas and whether malignant grading of gliomas is possible.MATERIALS AND METHODS: 7T SWI was performed on 21 patients with gliomas before surgery with optimization for sharp visualization of the corticomedullary junction. Scoring for cortical thickening and displacement of medullary vessels, characteristic of oligodendroglial tumors, and cortical tapering, characteristic of astrocytic tumors, was performed. Additionally, characteristics of malignancy, including thickening of the medullary veins, the presence of microbleeds, and/or necrosis were scored.RESULTS: Scoring for oligodendroglial (highest possible score, 13) and astrocytic (lowest score possible, À3) characteristics yielded a significant difference between astrocytomas and oligodendrogliomas (mean, À1.93 versus 11.71, P , .01). Scoring for malignancy was significantly different among the World Health Organization grade II (n ¼ 10), grade III (n ¼ 4), and grade IV (n ¼ 7) tumors (mean, 0.20 versus 1.38 versus 2.79). Cortical thickening was observed significantly more frequently in oligodendrogliomas (P , .02), with a sensitivity of 71.4% and specificity of 85.7%; observation of tapering of the cortex was higher in astrocytomas (P , .01) with a sensitivity of 85.7% and specificity of 100%.CONCLUSIONS: Visualization of the corticomedullary junction by 7T SWI was useful in distinguishing astrocytomas and oligodendrogliomas. Observation of tapering of the cortex was most sensitive and specific for diagnosing astrocytomas. Reliably predicting malignant grade was also possible by 7T SWI.

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Section: Application Of 7t Swi In Assessment Of Brain Tumors and Othe...mentioning

confidence: 99%

SWI by 7T MR Imaging for the Microscopic Imaging Diagnosis of Astrocytic and Oligodendroglial Tumors

Natsumeda¹,

Matsuzawa²,

Watanabe³

et al. 2022

AJNR Am J Neuroradiol

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“…A 2020 study showed that, compared to 3 T, 7 T scanners have up to 134% higher sensitivity for lesion detection. This led to better discrimination between cortical and WM lesions, and between leukocortical and WM lesions within the cerebellum in pwMS [64]. However, while lesion characterisation and volumetric MRI measures at all field strengths are useful for assessing structural changes associated with MS disease activity, they do not address any changes in FC or activity.…”

Section: Lesion and Volumetric Mrimentioning

confidence: 99%

An Update on the Measurement of Motor Cerebellar Dysfunction in Multiple Sclerosis

et al. 2022

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Multiple sclerosis (MS) is a progressive disease that often affects the cerebellum. It is characterised by demyelination, inflammation, and neurodegeneration within the central nervous system. Damage to the cerebellum in MS is associated with increased disability and decreased quality of life. Symptoms include gait and balance problems, motor speech disorder, upper limb dysfunction, and oculomotor difficulties. Monitoring symptoms is crucial for effective management of MS. A combination of clinical, neuroimaging, and task-based measures is generally used to diagnose and monitor MS. This paper reviews the present and new tools used by clinicians and researchers to assess cerebellar impairment in people with MS (pwMS). It also describes recent advances in digital and home-based monitoring for people with MS.

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“…The contribution of 7-T MRI for detecting MS white matter lesions is less robust than that for the cortex [ 43 ] with ongoing research in the optimization of sequences to reduce limitations secondary to high SAR and to reduce RF field inhomogeneities [ 43 – 45 ]. T2*, FLAIR, magnetization transfer imaging, and magnetization-prepared rapid gradient-echo have been suggested as currently recommended sequences to visualize white matter lesions at 7 T [ 43 , 46 , 47 ].…”

Section: Ultrahigh Field Mrimentioning

confidence: 99%

“…This observation lends support to CSF-mediated pathogenic mechanisms in lesion development that may differ between MS subtypes. Despite the potential theoretical benefits of imaging the spinal cord in MS at ultrahigh field, technical challenges remain, including the lack of dedicated RF coils that may compromise image quality; small variations in tissue susceptibility that are enhanced at 7 T; and motion artifacts due to respiration, cardiac movement, swallowing and CSF flow [ 32 , 43 ].…”

Section: Ultrahigh Field Mrimentioning

confidence: 99%

MRI with ultrahigh field strength and high-performance gradients: challenges and opportunities for clinical neuroimaging at 7 T and beyond

Vachha

Huang

2021

Eur Radiol Exp

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Research in ultrahigh magnetic field strength combined with ultrahigh and ultrafast gradient technology has provided enormous gains in sensitivity, resolution, and contrast for neuroimaging. This article provides an overview of the technical advantages and challenges of performing clinical neuroimaging studies at ultrahigh magnetic field strength combined with ultrahigh and ultrafast gradient technology. Emerging clinical applications of 7-T MRI and state-of-the-art gradient systems equipped with up to 300 mT/m gradient strength are reviewed, and the impact and benefits of such advances to anatomical, structural and functional MRI are discussed in a variety of neurological conditions. Finally, an outlook and future directions for ultrahigh field MRI combined with ultrahigh and ultrafast gradient technology in neuroimaging are examined.

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Ultra-high field 7 T imaging in multiple sclerosis

Cited by 8 publications

References 75 publications

SWI by 7T MR Imaging for the Microscopic Imaging Diagnosis of Astrocytic and Oligodendroglial Tumors

SWI by 7T MR Imaging for the Microscopic Imaging Diagnosis of Astrocytic and Oligodendroglial Tumors

An Update on the Measurement of Motor Cerebellar Dysfunction in Multiple Sclerosis

MRI with ultrahigh field strength and high-performance gradients: challenges and opportunities for clinical neuroimaging at 7 T and beyond

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