Ultra-high field (10.5T) diffusion-weighted MRI of the macaque brain

Grier, Mark D.; Yacoub, Essa; Adriany, Gregor; Lagore, Russell; Harel, Noam; Zhang, Ru‐Yuan; Lenglet, Christophe; Uğurbil, Kâmil; Zimmermann, Jan; Heilbronner, Sarah R.

doi:10.1016/j.neuroimage.2022.119200

Cited by 9 publications

(9 citation statements)

References 151 publications

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“…Structural imaging data was acquired for an anesthetized 4-year-old female Macaca fascicularis . The T1w structural scan was completed on a Siemens 10.5 T scanner with a 3D-MPRAGE sequence; FOV: 131 × 150 mm 2 ; matrix size of 280 × 320 (0.5 mm isotropic resolution); TR/TE of 3300/3.56 ms (Grier et al, 2022). The CT scan was completed on a Siemens Biograph64.…”

Section: Methodsmentioning

confidence: 99%

“…Numerical methods such as the finite element method (FEM) allow accurate simulations of NIBS electric fields for specific stimulation configurations and head models. Ultra-high field MRI scans enable imaging of NHP anatomy in unprecedented detail (Grier et al, 2022). In the present work, we leverage 10.5T anatomical MRI scans to create a detailed NHP head model.…”

Section: Introductionmentioning

confidence: 99%

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Systematic evaluation of anatomical details on transcranial electric stimulation and transcranial magnetic stimulation induced electric fields in a non-human primate model

Mantell

Shirinpour

Puonti

et al. 2022

Preprint

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Non-human primates (NHPs) have become key for translational research in noninvasive brain stimulation (NIBS). However, in order to create comparable stimulation conditions to humans it is vital to evaluate and match electric fields across species. Numerical models to simulate electric fields are an important tool for experimental planning in NHPs and translation to human studies. It is thus essential to evaluate how anatomical details in NHP models affect NIBS electric fields. Here, we create a highly accurate head model of a non-human primate (NHP) from 10.5 T MR data. We systematically evaluate how muscle tissue and head size (due to different MRI fields of view) affect simulation results in transcranial electric and magnetic stimulation (TES and TMS). Our findings indicate that the inclusion of muscle can affect TES electric field strength up to 29.5% while TMS is largely unaffected. Additionally, comparing a full head model to a cropped head model illustrates the impact of head size on electric fields for both TES and TMS. We find opposing effects between TES and TMS with an increase up to 13.5% for TES and a decrease up to 21.5% for TMS for the cropped head model compared to the full head model. Our results provide important insights into the level of anatomical detail needed for NHP head models and can inform future translational efforts for NIBS studies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systematic evaluation of anatomical details on transcranial electric stimulation and transcranial magnetic stimulation induced electric fields in a non-human primate model

Mantell

Shirinpour

Puonti

et al. 2022

Preprint

Self Cite

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“…Hence, the clinical relevance of DWI requires acquiring specimens in vivo for comparability to humans, in which proper perfusion and fixation are not feasible 30 . Since DWI sequences can be expensive to implement and challenging to process, several groups offered open access to datasets in humans 31 , macaques 32,33 , mice and other species [34][35][36][37] to fuel progress in neurosciences. However, the absence of a living squirrel monkey DWI dataset hampers the progress of comparative models and prevents us from building comprehensive and accurate evolutionary trees of the brain.…”

Section: Background and Summarymentioning

confidence: 99%

A new open, high-resolution, multishell, diffusion-weighted imaging dataset of the living squirrel monkey

et al. 2023

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Although very well adapted to brain study, Magnetic Resonance Imaging (MRI) remains limited by the facilities and capabilities required to acquire data, especially for non-human primates. Addressing the data gaps resulting from these limitations requires making data more accessible and open. In contempt of the regular use of Saimiri sciureus in neuroscience research, in vivo diffusion has yet to be openly available for this species. Here we built and made openly available a unique new resource consisting of a high-resolution, multishell diffusion-weighted dataset in the anesthetized Saimiri sciureus. The data were acquired on 11 individuals with an 11.7 T MRI scanner (isotropic resolution of 400 µm3). This paper presents an overview of our dataset and illustrates some of its possible use through example analyses. To assess the quality of our data, we analyzed long-range connections (whole-brain tractography), microstructure (Neurite Orientation Dispersion and Density Imaging), and axon diameter in the corpus callosum (ActiveAx). Constituting an essential new resource for primate evolution studies, all data are openly available.

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“…The use of an ultra-high-field MRI scanner allows for the differentiation of short association fibers within the cortex, which are often difficult to distinguish due to partial volume effects. 108 However, apart from its restricted accessibility, the utilization of ultrahigh-field MRI is impeded by technical challenges. One such challenge is the presence of B0 and B1 field inhomogeneities, which escalate with increasing field strength and lead to local fluctuations in signal intensity and signal dropout.…”

Section: Current Issues and Future Directionsmentioning

confidence: 99%

“…Imaging data from the macaque brain, obtained using a 10.5 T scanner, revealed high-quality tractograms and scalar diffusion metric maps in the white matter. The use of an ultra-high-field MRI scanner allows for the differentiation of short association fibers within the cortex, which are often difficult to distinguish due to partial volume effects 108 . However, apart from its restricted accessibility, the utilization of ultra-high-field MRI is impeded by technical challenges.…”

Section: Diffusion Mri Tractographymentioning

confidence: 99%

Advancements in Diffusion MRI Tractography for Neurosurgery

Kamagata,

Andica,

Uchida

et al. 2023

Invest Radiol

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Diffusion magnetic resonance imaging tractography is a noninvasive technique that enables the visualization and quantification of white matter tracts within the brain. It is extensively used in preoperative planning for brain tumors, epilepsy, and functional neurosurgical procedures such as deep brain stimulation. Over the past 25 years, significant advancements have been made in imaging acquisition, fiber direction estimation, and tracking methods, resulting in considerable improvements in tractography accuracy. The technique enables the mapping of functionally critical pathways around surgical sites to avoid permanent functional disability. When the limitations are adequately acknowledged and considered, tractography can serve as a valuable tool to safeguard critical white matter tracts and provides insight regarding changes in normal white matter and structural connectivity of the whole brain beyond local lesions. In functional neurosurgical procedures such as deep brain stimulation, it plays a significant role in optimizing stimulation sites and parameters to maximize therapeutic efficacy and can be used as a direct target for therapy. These insights can aid in patient risk stratification and prognosis. This article aims to discuss state-of-the-art tractography methodologies and their applications in preoperative planning and highlight the challenges and new prospects for the use of tractography in daily clinical practice.

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Ultra-high field (10.5T) diffusion-weighted MRI of the macaque brain

Cited by 9 publications

References 151 publications

Systematic evaluation of anatomical details on transcranial electric stimulation and transcranial magnetic stimulation induced electric fields in a non-human primate model

Systematic evaluation of anatomical details on transcranial electric stimulation and transcranial magnetic stimulation induced electric fields in a non-human primate model

A new open, high-resolution, multishell, diffusion-weighted imaging dataset of the living squirrel monkey

Advancements in Diffusion MRI Tractography for Neurosurgery

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