Ultra-flexible and brain-conformable micro-electrocorticography device with low impedance PEDOT-carbon nanotube coated microelectrodes

Castagnola, Elisa; Maiolo, Luca; Maggiolini, Emma; Minotti, A.; Marrani, Marco; Maita, Francesco; Pecora, A.; Angotzi, Gian Nicola; Ansaldo, Alberto; Fadiga, Luciano; Fortunato, G.; Ricci, Davide

doi:10.1109/ner.2013.6696087

Cited by 13 publications

(21 citation statements)

References 17 publications

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“…To verify in vivo performance of our platform, we fabricated a device consisting of single penetrating array with several microelectrodes flanked by two µECoG arrays with a spring like system that allows the intracortical array to be inserted to varying depths without changing the µECoG electrode placements. As PEDOT coatings are useful to guarantee low impedance and ideal electrode conductivity of miniaturized electrodes [33], we coated the 30 µm diameter GC microelectrodes with PEDOT-PSS, reinforced with CNTs, which further improve their mechanical and electrical properties [35][36][37][38][39]. Following fabrication, we performed an in vivo validation of the device by recording neural activity from the vibrissae representation of the rat primary somatosensory cortex (S1 (stacks.iop.org/JMM/28/065009/mmedia)), namely the barrel cortex, leveraging the well-known cytoarchitecture and the physiology of this region [40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Glassy carbon MEMS for novel origami-styled 3D integrated intracortical and epicortical neural probes

Goshi

Castagnola

Vomero

et al. 2018

J. Micromech. Microeng.

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We report on a novel technology for microfabricating 3D origami-styled micro electromechanical systems (MEMS) structures with glassy carbon (GC) features and a supporting polymer substrate. GC MEMS devices that open to form 3D microstructures are microfabricated from GC patterns that are made through pyrolysis of polymer precursors on high-temperature resisting substrates like silicon or quartz and then transferring the patterned devices to a flexible substrate like polyimide followed by deposition of an insulation layer. The devices on flexible substrate are then folded into 3D form in an origami-fashion. These 3D MEMS devices have tunable mechanical properties that are achieved by selectively varying the thickness of the polymeric substrate and insulation layers at any desired location. This technology opens new possibilities by enabling microfabrication of a variety of 3D GC MEMS structures suited to applications ranging from biochemical sensing to implantable microelectrode arrays. As a demonstration of the technology, a neural signal recording microelectrode array platform that integrates both surface (cortical) and depth (intracortical) GC microelectrodes onto a single flexible thin-film device is introduced. When the device is unfurled, a pre-shaped shank of polyimide automatically comes

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Section: Introductionmentioning

confidence: 99%

Glassy carbon MEMS for novel origami-styled 3D integrated intracortical and epicortical neural probes

Goshi

Castagnola

Vomero

et al. 2018

J. Micromech. Microeng.

Self Cite

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“…Additionally, another unique feature of these materials is the mixed electronic and ionic conductivity [139]. This property is crucial in detecting biological signals, enabling low-impedance electrodes [140][141][142]. Once again consumer electronics has been the first promoter for organic electronics innovation, providing high contrast and high brightness flat panel display based on organic light-emitting diode (OLED).…”

Section: Organic Electronicsmentioning

confidence: 99%

The rise of flexible electronics in neuroscience, from materials selection to in vitro and in vivo applications

Maiolo

Polese

Convertino

2019

Advances in Physics: X

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Neuroscience deals with one of the most complicate system we can study: the brain. The huge amount of connections among the cells and the different phenomena occurring at different scale give rise to a continuous flow of data that have to be collected, analyzed and interpreted. Neuroscientists try to interrogate this complexity to find basic principles underlying brain electrochemical signalling and human/animal behaviour to disclose the mechanisms that trigger neurodegenerative diseases and to understand how restoring damaged brain circuits. The main tool to perform these tasks is a neural interface, a system able to interact with brain tissue at different levels to provide a uni/bidirectional communication path. Recently, breakthroughs coming from various disciplines have been combined to enforce features and potentialities of neural interfaces. Among the different findings, flexible electronics is playing a pivotal role in revolutionizing neural interfaces. In this work, we review the most recent advances in the fabrication of neural interfaces based on flexible electronics. We define challenges and issues to be solved for the application of such platforms and we discuss the different parts of the system regarding improvements in materials selection and breakthrough in applications both for in vitro and in vivo tests.

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“…Castagnola et al have also shown the use of PEDOT-carbon nanotube (CNT) coated micro-electrodes for us in micro-electrocorticography arrays (Castagnola et al, 2013). These devices were patterned onto a polyimide substrate and their viability was verified by recording of sensory evoked potentials in the rat cerebral cortex.…”

Section: Current State Of the Artmentioning

confidence: 99%

“…(b) Scanning electron micrograph of the surface of PEDOT-CNT coated microelectrodes. (Castagnola et al, 2013)…”

Section: Figurementioning

confidence: 99%

Advanced materials for neural surface electrodes

Schendel

Eliceiri

Williams

2014

Current Opinion in Solid State and Materials Science

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Designing electrodes for neural interfacing applications requires deep consideration of a multitude of materials factors. These factors include, but are not limited to, the stiffness, biocompatibility, biostability, dielectric, and conductivity properties of the materials involved. The combination of materials properties chosen not only determines the ability of the device to perform its intended function, but also the extent to which the body reacts to the presence of the device after implantation. Advances in the field of materials science continue to yield new and improved materials with properties well-suited for neural applications. Although many of these materials have been well-established for non-biological applications, their use in medical devices is still relatively novel. The intention of this review is to outline new material advances for neural electrode arrays, in particular those that interface with the surface of the nervous tissue, as well as to propose future directions for neural surface electrode development.

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Ultra-flexible and brain-conformable micro-electrocorticography device with low impedance PEDOT-carbon nanotube coated microelectrodes

Cited by 13 publications

References 17 publications

Glassy carbon MEMS for novel origami-styled 3D integrated intracortical and epicortical neural probes

Glassy carbon MEMS for novel origami-styled 3D integrated intracortical and epicortical neural probes

The rise of flexible electronics in neuroscience, from materials selection to in vitro and in vivo applications

Advanced materials for neural surface electrodes

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