Ultra fine super self-nanoemulsifying drug delivery system (SNEDDS) enhanced solubility and dissolution of indomethacin

Shakeel, Faiyaz; Haq, Nazrul; El-Badry, Mahmoud; Alanazi, Fars K.

doi:10.1016/j.molliq.2013.01.008

Cited by 93 publications

(101 citation statements)

References 23 publications

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“…The negative charge of ZP on prepared micro-emulsions was probably due to the presence of fatty acid esters in eucalyptus oil. The ZP values in the magnitude of AE30 mV indicated the stable formation of liposomes and micro-emulsions (Shakeel et al, 2013). The EE of the drug in the prepared micro-emulsions (ME1 or ME2) was observed in the range of 97-98% which were significantly higher than liposomes.…”

Section: Characterization Of Liposomes and Micro-emulsionsmentioning

confidence: 91%

Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations

2013

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Section: Characterization Of Liposomes and Micro-emulsionsmentioning

confidence: 91%

Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations

2013

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“…To perform this test, 1 ml of each CEO nanoemulsion F1-F5 was diluted with 500 ml of deionized water. The efficiency of each nanoemulsion was investigated visually using the following grading systems 32,33 :…”

Section: Preparation Of Ceo Nanoemulsionsmentioning

confidence: 99%

Enhanced Antibacterial Effects of Clove Essential Oil by Nanoemulsion

et al. 2014

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“…Thermodynamic Stability Studies: SNEDDS was subjected to thermodynamic stability studies in order to access any phase separation and stability of the prepared formulation 24,25 .…”

Section: Determination Of Partition Coefficientmentioning

confidence: 99%

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2017

IJPSR

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Self nano-emulsifying system drug delivery system (SNEDDS) is promising for drugs of BCS class II. The objective of present study to develop self nano-emulsifying drug delivery system for Lipophillic drug Telmisartan (antihypertensive drug), labrafil 1944, Kolliphor ELP: Span 80 (1:1) and PEG 400: Ethanol (1:1) was chosen as oil, Surfactant and Co-surfactant as they show higher solubility for Telmisartan. Screening of Surfactant, Co-surfactant done by percent transmittance and were also observed for turbidity or phase separation visually. Pseudo ternary phase diagram were constructed to identify the self emulsifying regions and also to establish the optimum concentration of oil, surfactant and co-surfactant. Box bhenken desine applied for optimization of formulation. Prepared formulation further Characterization done. Percent Drug Content found 99.71, thermodynamic stability studies show homogenous and no phase separation, Emulsifying Study performed transparent appearance after 24 hr, for robustness Dilutability in water and 0.1N HCl give Percentage Transmittance 99.5 and 100, conducting in vitro dissolution test compared with marketed preparation in stimulated gastric (S.G.F) pH 1.2 showed Percent Drug Release 93.98 with in 30 min, compared by pure drug which was 14.26. Particle size found 164.9 nm which is under nano size range, performing Poly Dispersity Index (PDI) 0.228, Zeta Potential found to be -26.0 mV, by using particle size analyzer.TEM study shows uniform spherical nano emulsion droplets. From the present study it is clear that SNEDDS can be formulated to improve the dissolution and oral bioavailability of poorly water soluble drug Telmisartan.

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Ultra fine super self-nanoemulsifying drug delivery system (SNEDDS) enhanced solubility and dissolution of indomethacin

Cited by 93 publications

References 23 publications

Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations

Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations

Enhanced Antibacterial Effects of Clove Essential Oil by Nanoemulsion

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