Ultra-fast bacterial inactivation of Cu2O@halloysite nanotubes hybrids with charge adsorption and physical piercing ability for medical protective fabrics

Wang, Yaping; Wang, Qianqian; Wu, Guoyi; Innocent, Mugaanire Tendo; Zhai, Mian; Jia, Chao; Zou, Peng; Zhou, Jialiang

doi:10.1016/j.jmst.2021.12.059

Cited by 22 publications

(5 citation statements)

References 45 publications

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“…Silver and copper nanoparticles, due to their small size, high surface activity and broad-spectrum antibacterial properties, are widely used as antibacterial agents in coatings, plastics and other materials to protect them from microbial attack. 10–17 Among them, copper nanoparticles are not only inexpensive and less biotoxic, but also have better antibacterial properties than silver nanoparticles. 18–23 In addition, copper plays an important role in human metabolism as one of the important trace elements and an essential cofactor of metalloproteins.…”

Section: Introductionmentioning

confidence: 99%

Dual functionalized copper nanoparticles for thermoplastics with improved processing and mechanical properties and superior antibacterial performance

Tian,

Sun,

Gao

et al. 2024

Nanoscale

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Section: Introductionmentioning

confidence: 99%

Dual functionalized copper nanoparticles for thermoplastics with improved processing and mechanical properties and superior antibacterial performance

Tian,

Sun,

Gao

et al. 2024

Nanoscale

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“…(3) The preparation of small-sized nano Cu 2 O particles on halloysite nanotubes has been carried out. Most importantly, HNTs with positive charges on the surface could enhance their interaction with bacteria and cause physical damage [12,13].…”

Section: Introductionmentioning

confidence: 99%

Using Temperature-Programmed Photoelectron Emission (TPPE) to Analyze Electron Transfer on Metallic Copper and Its Relation to the Essential Role of the Surface Hydroxyl Radical

Momose

2024

Applied Sciences

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Surface processes such as coatings, corrosion, photocatalysis, and tribology are greatly diversified by acid–base interactions at the surface overlayer. This study focuses on the action of a metallic copper surface as an electron donor/acceptor related to the inactivation of viruses. It was found that regarding Cu2O or Cu materials, electrostatic interaction plays a major role in virus inactivation. We applied the TPPE method to clarify the mechanism of electron transfer (ET) occurring at light-irradiated copper surfaces. The TPPE characteristics were strongly influenced by the environments, which correspond to the temperature and environment dependence of the total count of emitted electrons in the incident light wavelength scan (PE total count, NT), the photothreshold, and further the activation energy (ΔE) analyzed from the Arrhenius plot of NT values obtained in the temperature increase and subsequent temperature decrease processes. In this study, we re-examined the dependence of the TPPE data from two types of Cu metal surfaces: sample A, which was mechanically abraded in alcohols, water, and air, and sample C, which was only ultrasonically cleaned in these liquids. The NT for both samples slowly increased with increasing temperature, reached a maximum (NTmax) at 250 °C (maximum temperature, Tmax), and after that, decreased. For sample A, the NTmax value decreased in the order H2O > CH3OH > C2H5OH > (CH3)2CHOH > C3H7OH, although the last alcohol gave Tmax = 100 °C, while with sample C, the NTmax value decreased in the order C3H7OH > (CH3)2CHOH > C2H5OH > CH3OH > H2O. Interestingly, both orders of the liquids were completely opposite; this means that a Cu surface can possess a two-way character. The NT intensity was found to be strongly associated with the change from the hydroxyl group (–Cu–OH) to the oxide oxygen (O2−) in the O1s spectra in the XPS measurement. The difference between the above orders was explained by the acid–base interaction mode of the –Cu–OH group with the adsorbed molecule on the surfaces. The H2O adsorbed on sample A produces the electric dipole –CuOδ−Hδ+ ⋅⋅⋅ :OH2 (⋅⋅⋅ hydrogen bond), while the C3H7OH and (CH3)2CHOH adsorbed on sample C produce RO−δHδ+ ⋅⋅⋅ :O(H)–Cu− (R = alkyl groups). Gutmann’s acceptor number (AN) representing the basicity of the liquid molecules was found to be related to the TPPE characteristics: (CH3)2CHOH (33.5), C2H5OH (37.1), CH3OH (41.3), and H2O (54.8) (the AN of C3H7OH could not be confirmed). With sample A, the values of NTmaxa and ΔEaUp1 both increased with increasing AN (Up1 means the first temperature increase process). On the other hand, with sample C, the values of NTmaxc and ΔEcUp1 both decreased with increasing AN. These findings suggest that sample A acts as an acid, while sample C functions as a base. However, in the case of both types of samples, A and C, the NTmax values were found to increase with increasing ΔEUp1. It was explained that the ΔEUp1 values, depending on the liquids, originate from the difference in the energy level of the hydroxyl group radical at the surface denoted. This is able to attract electrons in the neighborhood of the Fermi level of the base metal through tunnelling. After that, Auger emission electrons are released, contributing to the ET in the overlayer. These electrons are considered to have a strong ability of reducibility.

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“…In this study, we aim to fabricate a cuprous oxide (Cu 2 O)-decorated electrospun fiber platform for combating bacterial infections and ameliorating wound repair (Scheme ). As a versatile type of nanoantimicrobial, cubic Cu 2 O nanoparticles (NPs) are cheap, easily synthesizable, and catalytically active in mediating both Fenton-like reactions and visible-light-induced PDT effect to ensure adequate antibacterial reactive oxygen species (ROS) production. , The synthetic Cu 2 O NPs serve as not only Cu 2+ ion sources but also excellent PDT agents . They could be uniformly incorporated into polycaprolactone (PCL) nanofibers during a composite electrospinning process.…”

Section: Introductionmentioning

confidence: 99%

Cu₂O Nanocubes Embedded in Polycaprolactone Nanofibers for Photo–chemotherapeutic Wound Disinfection and Regeneration

Zhao,

Yang,

et al. 2024

ACS Appl. Nano Mater.

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Wound-associated infections represent an arduous global healthcare challenge, especially in the "post-antibiotic" era, necessitating the development of advanced antimicrobial dressing materials that simultaneously dictate the use of rapid yet effective disinfection, low drug resistance and side effects, and the potency to foster tissue healing. Nanoantimicrobial-armored nanostructured functional dressing systems have piqued extensive interest to satisfy these criteria. Herein, fusing electrospinning nanotechnology and an emerging photo−chemo synergistic sterilization paradigm, a smart "all-in-one" multifunctional wound-managing dressing platform was constructed, through incorporating photochemically active nanocrystalline cuprous oxide (Cu 2 O) into modified polycaprolactone (mPCL) electrospun fibrous mats. The resulting materials were systematically characterized pertaining to physiochemical analysis, photoabsorption and photocurrent measurements, and photocatalytic reactive oxygen species (ROS) generation. The capability of this nanoplatform to elicit rapid, photoactivated, catalytically augmented bacterial disinfection was corroborated, displaying ∼99−100% broad-spectrum antibacterial efficacies against Staphylococcus aureus and Escherichia coli in 25 min. Benefiting from the release of Cu 2+ , mPCL-Cu 2 O impairs bacterial contamination even under dark conditions. Furthermore, these materials also exhibited favorable in vitro/-ovo biocompatibility toward NIH3T3 fibroblasts, red blood cells, and chick chorioallantoic membrane, alongside appreciable pro-healing capacity in bridging scratch-based wounds, which could be attributed to nanofiber-afforded biomimetic topography and controllable liberation of micronutrient Cu ions. This study provides insights into the design and fabrication of simple yet smart antibacterial nanoplatforms for biomedical applications.

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Ultra-fast bacterial inactivation of Cu2O@halloysite nanotubes hybrids with charge adsorption and physical piercing ability for medical protective fabrics

Cited by 22 publications

References 45 publications

Dual functionalized copper nanoparticles for thermoplastics with improved processing and mechanical properties and superior antibacterial performance

Dual functionalized copper nanoparticles for thermoplastics with improved processing and mechanical properties and superior antibacterial performance

Using Temperature-Programmed Photoelectron Emission (TPPE) to Analyze Electron Transfer on Metallic Copper and Its Relation to the Essential Role of the Surface Hydroxyl Radical

Cu₂O Nanocubes Embedded in Polycaprolactone Nanofibers for Photo–chemotherapeutic Wound Disinfection and Regeneration

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Ultra-fast bacterial inactivation of Cu2O@halloysite nanotubes hybrids with charge adsorption and physical piercing ability for medical protective fabrics

Cited by 22 publications

References 45 publications

Dual functionalized copper nanoparticles for thermoplastics with improved processing and mechanical properties and superior antibacterial performance

Dual functionalized copper nanoparticles for thermoplastics with improved processing and mechanical properties and superior antibacterial performance

Using Temperature-Programmed Photoelectron Emission (TPPE) to Analyze Electron Transfer on Metallic Copper and Its Relation to the Essential Role of the Surface Hydroxyl Radical

Cu2O Nanocubes Embedded in Polycaprolactone Nanofibers for Photo–chemotherapeutic Wound Disinfection and Regeneration

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Cu₂O Nanocubes Embedded in Polycaprolactone Nanofibers for Photo–chemotherapeutic Wound Disinfection and Regeneration