Ulmus davidiana var. japonica Nakai Upregulates Eosinophils and Suppresses Th1 and Th17 Cells in the Small Intestine

Lee, Hansung; Jang, Min Seong; Kim, Junghwan; Hong, Chun-Pyo; Lee, Eunjung; Jeun, Eun Ji; Kim, Chan; Kim, Min Jung; Ahn, Kwang-Seong; Yang, Bo-Gie; Ahn, Kwang Seok; Jang, Young Pyo; Ahn, Kwang‐Soon; Kim, You-Me; Jang, Myoung Ho

doi:10.1371/journal.pone.0076716

Cited by 10 publications

(5 citation statements)

References 30 publications

(35 reference statements)

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“…Supporting this finding, the extract of Ulmus davidiana var. japonica Nakai up-regulates eosinophils and reduces the frequencies of Th1 as well as Th17 cells in the small intestine ( Lee et al, 2013 ). Contrary to eosinophil-deficient ΔdblGATA-1 mice, IL-1Ra–deficient mice did not show a significant increase of Th1 cells in the small intestine ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

Sugawara

Lee

Jang

et al. 2016

Journal of Experimental Medicine

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Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the ΔdblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4+ T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1β. Moreover, small intestinal eosinophils isolated from IL-1Ra−deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.

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Section: Discussionmentioning

confidence: 99%

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

Sugawara

Lee

Jang

et al. 2016

Journal of Experimental Medicine

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“…The extract of Ulmus davidiana var. japonica Nakai increases the number of small-intestinal eosinophils and suppresses differentiation and/or proliferation of Th1 and Th17 cells ( 40 ). Regulatory eosinophil-recruiting prebiotics or probiotics may be useful for prevention of inflammatory and metabolic diseases.…”

Section: Prospectsmentioning

confidence: 99%

Regulatory Eosinophils in Inflammation and Metabolic Disorders

2017

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Eosinophils are potent effector cells implicated in allergic responses and helminth infections. Responding to stimuli, they release their granule-derived cytotoxic proteins and are involved in inflammatory processes. However, under homeostatic conditions, eosinophils are abundantly present in the intestine and are constantly in contact with the gut microbiota and maintain the balance of immune responses without inflammation. This situation indicates that intestinal eosinophils have an anti-inflammatory function unlike allergic eosinophils. In support of this notion, some papers have shown that eosinophils have different phenotypes depending on the site of residence and are a heterogeneous cell population. Recently, it was reported that eosinophils in the small intestine and adipose tissue, respectively, contribute to homeostasis of intestinal immune responses and metabolism. Accordingly, in this review, we summarize new functions of eosinophils demonstrated in recent studies and discuss their homeostatic functions.

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“…Previous research indicated that UD extracts had various ameliorative effects on acute inflammatory responses in rats [9,10], osteopenia [11], and an in vitro model [12]. Similarly, the supercritical fluid of UD had anti-inflammatory, anti-angiogenesis [13], and anti-melanin effects [14].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Cytokines and Dihydrotestosterone Production in Human Hair Follicle Papilla Cells by Supercritical Extraction-Residues Extract of Ulmus davidiana

2022

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This study was conducted to examine the anti-hair loss mechanism of the supercritical fluid extraction-residues extract of Ulmus davidiana by the regulation of cytokine production and hormone function in human dermal follicle papilla cells (HDFPCs). To investigate the modulatory effects on H2O2-induced cytokines, we measured transforming growth factor-beta and insulin-like growth factor 1 secreted from HDFPCs. To investigate the regulatory effects of supercritical extraction-residues extract of Ulmus davidiana on dihydrotestosterone hormone production, cells were co-incubated with high concentrations of testosterone. The supercritical extraction-residues extract of Ulmus davidiana significantly inhibited the secretion of transforming growth factor-beta but rescued insulin-like growth factor 1 in a dose-dependent manner. The supercritical extraction-residues extract of Ulmus davidiana markedly reduced dihydrotestosterone production. These results suggest that the supercritical fluid extract residues of Ulmus davidiana and their functional molecules are candidates for preventing human hair loss.

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Ulmus davidiana var. japonica Nakai Upregulates Eosinophils and Suppresses Th1 and Th17 Cells in the Small Intestine

Cited by 10 publications

References 30 publications

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

Regulatory Eosinophils in Inflammation and Metabolic Disorders

Regulation of Cytokines and Dihydrotestosterone Production in Human Hair Follicle Papilla Cells by Supercritical Extraction-Residues Extract of Ulmus davidiana

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