Ulcus, Stress und Schizophrenie

Abstract

According to the hypothesis of a biochemical disorder, we found that schizophrenic patients show a modified reaction to stress. We have checked 668 male schizophrenic patients and found 18 ulcers (2.69%) this is contrasted by the average incidence of ulcers at the rate of 10%.12 of the 18 probands had preliminary serious somatic lesions. We came to the conslusion that the hypothalamic stress response is altered: Schizophrenic patients and the normal population show a significant difference to the incidence of gastric ulcers.

Gastric and Duodenal Anti-ulcer Activity of SKF 38393, a Dopamine D1-Receptor Agonist in Rats

“…It has been implicated in the genesis of experimentally-induced gastric and duodenal ulcers (Szabo 1979;Hernandez et al 1984;Sikiric et al 1985). Clinically, a high incidence of duodenal ulcers has been observed in patients with Parkinson's disease (associated with dopamine deficiency) and a low occurrence is seen in schizophrenics (associated with dopamine excess or hyperactivity) (Strang 1965;Hinterhuber & Hochenegg 1975). Ulcerogenic as well as anti-ulcer activity has been reported with different dopamine agonists and antagonists (Szabo 1979;Parmar et al 1984;Sikiric et a1 1986;Glavin & Dugani 1987).…”

Gastric and duodenal anti-ulcer activity of sulpiride, a dopamine D2 receptor antagonist, in rats

“…Clinically too, a high incidence of duodenal ulcers has been observed in patients with Parkinson's disease (associated with dopamine deficiency) and a low occurrence is seen in schizophrenics (associated with dopamine excess or hyperactivity) [6,7]. It has been * Present address: Department of Pharmacology, L.M.…”