Ulcerative Sarcoidosis

Albertini, John G.

doi:10.1001/archderm.1997.03890380087013

Cited by 61 publications

(28 citation statements)

References 7 publications

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“…Evidence of extracutaneous sarcoidosis was found in many of these patients. We found that 15 ofthe 22 patients had lung lesions, whereas Albertini et al (2) demonstrated that 12 of 35 cases had respiratory symptoms.…”

Section: Discussionmentioning

confidence: 49%

“…Sixteen patietits had leg ulcers, 2 had head ulcers., one had a buttock ulcer, and 2 had multiple lesions. In the review by Albertini et al (2), U of 35 cases presented with ulcération as the earliest manifestation. However, 17 of 19 Japanese patients had previously been diagnosed with sarcoidosis more than one year before the appearance ofthe uicerative skin lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Our patient showed a good response to prednisolone therapy for his skin lesions and uveitis. Corticosteroids and methotrexate have also been shown to be effective treatment (2). In ulcerative sarcoidosis, treatment failures have been reported with the use of many types of treatment, such as chloroquine, topical corticosteroids, isotretinoin, antibiotics, anti-ulcer cream.…”

Section: Discussionmentioning

confidence: 99%

“…In ulcerative sarcoidosis, treatment failures have been reported with the use of many types of treatment, such as chloroquine, topical corticosteroids, isotretinoin, antibiotics, anti-ulcer cream. X-ray therapy and skin grafts (2). Recently, adalimumab.…”

Section: Discussionmentioning

confidence: 99%

“…The vast majority of lesions are solitary and occur in the head and neck region. Their occurrence at other anatomical sites is uncommon, and linear arrangements of these lesions are particularly rare (2). We report here an unusual case of multiple SCAP in a linear distribution presenting on the arm.…”

Section: Linear Synngocystadenoma Papilliferum Of the Arm: A Rare Locmentioning

confidence: 91%

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Ulcerative Sarcoidosis: Case Report and Review of the Japanese Literature

Ichiki¹,

Kitajima²

2008

Acta Derm Venerol

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Sarcoidosis is a chronic multi-system disease of unknown origin involving the eyes, skin, lungs, heart, bones and nerves. Skin lesions are relatively common, and are classified as either specific or non-specific (I). Specific lesions are those that show the typical sarcoid granulomas, including lupus pernio, infiltrated plaques, macuiopapuiar eruptions, subcutaneous nodules and infiltration of old scars (I). The most typical non-specific skin lesion is erythema nodosum. The patient described here had skin lesions that first suggested a diagnosis of erythema induratum of Bazin, but we ultimately diagnosed sarcoidosis based on other findings, including uveitis, bilateral hilar lymphadenopathy, an increased level of serum angiotensin-converting enzymes (ACE) and a negative response to purified protein derivative of tuberculin (PPD). the deep dermis and the subcutaneous tissue (Fig. 2a). Caseation necrosis and Langerhans' giant cells were partially seen among the epithelioid granulomas (Fig. 2b). Several small vessels in the deep dermis were involved, with granuloma and disruption of elastic fibre (Fig. 2c). Acid-fast bacilli were not found in the paraffin section ofthe specimen stained by Ziehl-Neelsen melhod and by PCR. Skin test with PPD showed no erythema at 48 h. Cultures of sputum and broncho-alveolar lavage (BAL) fluid were negative for acid-fast bacilli and common bacteria. The ratio of helper to suppressor T cells in BALfluid was 5,8. The lung biopsy specimen obtained by the transbronchial method demonstrated epithclioid granulomas without caseation necrosis. Mediastinal adenopathy was found to be present on computed tomography ofthe chest. Sarcoidosis was finally diagnosed 8 weeks after the initial presentation. At that time, a daily dosage of prednisolone (30 mg) was prescribed for the uveitis. with a gradual reduction to 10 mg directed by the patient's ophthalmologist. After 6 months of treatment with prednisolone, the erythematous induration with ulcers had healed, leaving scars. CASE REPORTA 59-year-old man presented with a 6-week history of a progressive, erythematous induration on the legs and arms. He had a medical history of uveitis, but not of tuberculosis. When first seen, he had multiple erythematous induration with tendemess on the arms and legs, linear ulcers and reticulated reddish-biue discoloration mostly on the edge ofthe erythema on the left leg (Fig. 1 ). A chest X-ray revealed diffuse changes suggestive of chronic bronchitis. Results from laboratory test, including a full blood count, urinalysis and liver function test, were normal except for elevated ACE (79.8 U/I, normal range: 7-25 U/1), elevated lysozymes (90 |Jg/ml, normal: 5-10 |ig/ml). and slightly elevated CRP ( 1.36 mg/dl. normal:

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Linear Synngocystadenoma Papilliferum Of the Arm: A Rare Locmentioning

confidence: 91%

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Ulcerative Sarcoidosis: Case Report and Review of the Japanese Literature

Ichiki¹,

Kitajima²

2008

Acta Derm Venerol

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Cutaneous Sarcoidosis

Rosenbach

English

2014

Evidence‐Based Dermatology

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Sarcoidosis

Marcoval,

Mañá

2016

Rook's Textbook of Dermatology, Ninth Edition

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Sarcoidosis is an antigen‐mediated disease of unknown aetiology characterized by the presence of non‐caseating epithelioid cell granulomas in multiple organs. It involves mainly the lungs, mediastinal and peripheral lymph nodes, eyes and skin. Less frequent but usually severe manifestations can occur in the liver, spleen, central nervous system, heart, upper respiratory tract and bones. Cutaneous lesions of sarcoidosis may be specific, showing histopathologically sarcoid granulomas, or non‐specific, mainly erythema nodosum. Cutaneous lesions are frequently the presentation of the disease and skin biopsy enables early diagnosis. Moreover, some types of lesions have prognostic significance and may help to predict the outcome of the systemic disease.

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Ulcerative Sarcoidosis

Cited by 61 publications

References 7 publications

Ulcerative Sarcoidosis: Case Report and Review of the Japanese Literature

Ulcerative Sarcoidosis: Case Report and Review of the Japanese Literature

Cutaneous Sarcoidosis

Sarcoidosis

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