Ulcerative Proctitis

Whitlow, Charles B.

doi:10.1055/s-2004-823067

Cited by 10 publications

(10 citation statements)

References 37 publications

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“…In addition, patients with ulcerative proctitis may receive reduced or delayed benefits from surgery compared with those with more extensively-located disease. Therefore, surgery is rarely indicated for this population, while infliximab has shown efficacy in bringing clinical response in patients with ulcerative proctitis (Whitlow 2004 ; Bouguen et al 2010 ). Colectomy may thus not be a “ one size fits all ” solution.…”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of colectomy surgery among patients with ulcerative colitis

et al. 2015

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The objective of this study was to evaluate long-term health-related quality of life outcomes among patients who had a colectomy within the previous 10 years. A cross-sectional survey was administered to consecutive patients ≥18 years of age with ulcerative colitis who had a colectomy within the last 10 years from centers in Canada, Australia, and the United Kingdom. Data were extracted from medical chart reviews to confirm selected self-reported patient characteristics. Of 351 survey respondents, 49 % were male and the median age was 40 years (interquartile range 30–52). Respondents were diagnosed with UC a median of 9.2 (5.7–15.1) years prior to the survey and first surgery occurred a median of 3.7 (2.1–5.8) years ago. Although most respondents (84 %) reported improved quality of life compared to the status before surgery, 81 % experienced problems in at least one of the following areas: depression, work productivity, restrictions in diet, body image, and sexual function. According to HADS scores, 30 and 17 % of survey respondents experienced anxiety and depression, respectively. Among moderate to severe UC patients pre-colectomy, 27 % of men and 28 % of women reported that their sexual life was worse now than before surgery. The mean EQ-5D utility index score overall was 0.79 (95 % confidence interval 0.77–0.81). Quality of life after colectomy for UC is generally good, but there are persistent quality of life issues that impact multiple domains, including psychological and sexual functioning.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-015-1350-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Long-term outcomes of colectomy surgery among patients with ulcerative colitis

et al. 2015

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“…The mainstay of treatment for ulcerative proctitis is represented by topical aminosalicilates and/or topical steroids. Oral steroids are sometimes used in case of unresponsiveness to topical therapy[ 21 ]. Moreover, it has been suggested that oral mesalamine can reduce the risk of disease extension[ 22 ].…”

Section: Isolated Ulcerative Proctitis and Ileorectal Anastomosismentioning

confidence: 99%

Orphan patients with inflammatory bowel disease - when we treat beyond evidence

Privitera¹,

Pugliese²,

Lopetuso³

et al. 2021

WJG

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Inflammatory bowel disease (IBD) is a chronic condition that requires continuous medical treatment. To date, the medical management of patients with moderately-to-severely active IBD who develop dependence or resistance to corticosteroids is based on immunomodulator drugs. Such therapies are licenced after passing through three phases of randomized controlled trials (RCTs), and are subsequently adopted in clinical practice. However, the real-life population of IBD patients who require these therapies can significantly differ from those included in RCTs. As a matter of fact, there is a number of exclusion criteria – nearly ubiquitous in all RCTs – that prevent the enrolment of specific patients: Chronic refractory pouchitis or isolated proctitis in ulcerative colitis, short-bowel syndrome and stomas in Crohn’s disease, ileorectal anastomosis in both ulcerative colitis and Crohn’s disease, and elderly age are some representative examples. In this frontier article, we aim to give an overview of current literature on this topic, in order to address the main knowledge gaps that need to be filled in the upcoming years.

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“…Refractory UP is defined as more than three relapses per year, chronic disease activity on continuous medications, or need for systemic corticosteroid or immunomodulatory therapy [3]. It should be noted that the criteria for defining refractory UP are different from those pertaining to UC, since UP seldom presents with systemic features like fever or anemia.…”

Section: Course Over Timementioning

confidence: 99%

“…It must be remembered however that Crohn's disease, with its cobblestoned mucosa and irregular, large and deep ulcerations can occasionally occur confined to the rectum [2], and the distinction from UP is important since the treatment and prognosis are very different. Ischemia in the rectum, radiation-induced proctitis, toxic injury, infections like cytomegalic virus and Clostridium difficile pseudomembranous colitis, parasites and sexually-transmitted diseases all enter into the differential diagnosis of UP [3]. The etiology of UP is likely the same as the etiology of UC, which is to say that it is basically unknown.…”

Section: Introductionmentioning

confidence: 99%