Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14

Association between CD14 polymorphisms and serum soluble CD14 levels: Effect of atopy and endotoxin inhalation

“…Even though we observed a differential effect of inhaled endotoxin on the association between CD14 polymorphisms and sCD14 levels, there was no relation between CD14 polymorphisms and the acute-phase reaction, as measured by means of LBP, CRP, and WBC levels. This might seem paradoxical in light of the numerous articles showing an association between CD14 polymorphisms and inflammatory diseases 28,[32][33][34][35][36] ; however, these results could be explained by several mechanisms.…”

“…16 Baldini et al 16 found that CD14/2159TT homozygotes had significantly higher sCD14 levels than did carriers of the CC and CT genotypes. Although several studies have confirmed this association between various CD14 polymorphisms and sCD14 levels, 17,18,[25][26][27][28] virtually none have considered the effect of endotoxin exposure on this relationship. In this study we found that the relationship between CD14 polymorphisms and circulating sCD14 levels is modulated by endotoxin inhalation.…”

Polymorphisms in Genes Related to Bacterial Lipopolysaccharide/Peptidoglycan Signaling and Gastric Precancerous Lesions in a Population at High Risk for Gastric Cancer

“…Since this variant-allele has been postulated to entail enhanced inflammatory reactions, its association has been studied for various inflammatory conditions, including cardiovascular disease. With regard to gastrointestinal conditions, an increased risk for ulcerative colitis and Crohn's disease was found among individuals carrying the T-allele or TT genotype [21][22][23], while other studies did not confirm these associations [24][25][26]. LPS from HP is known to be much less potent in inducing inflammatory reactions than LPS from other Gram-negative bacteria, such as Escherichia coli [27].…”

Macrophage migration inhibitory factor, Toll-like receptor 4, and CD14 polymorphisms with altered expression levels in patients with ulcerative colitis

“…Ample evidence exists linking genetic polymorphisms in CD14, TLR4, and MIF genes with various complex human diseases [19,22,23]. However, data demonstrating their effects in UC development are lacking [6,7,9,10,17,24]. Hence, in this report, we studied the effects of CD14, TLR4, and MIF polymorphisms in patients with active UC.…”