Ulcerative Colitis in Singapore: Epidemiology and clinical features

Lim, Kim Wei; Kwek, Andrew; Fock, Kwong Ming; Teo, Eng Kiong; Ong, Jeannie; Tan, Jessica; Ang, Juliana

doi:10.1097/00054725-200912002-00065

Cited by 1 publication

(1 citation statement)

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“…Most of the included studies were retrospective (36 articles). Among the included studies, six were from India, 12–17 four from Korea, 18–21 seven from Japan, 22–28 eight from China, 29–36 three each from Taiwan, 37–39 Singapore, 40–42 Malaysia, 43–45 and Israel, 46–48 two from Turkey, 49,50 and one each from Kuwait, 51 Sri Lanka, 52 Jordan, 53 Iran, 54 and Oman. 55 Six studies reported colorectal cancer risk in patients undergoing routine surveillance.…”

Section: Resultsmentioning

confidence: 99%

Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis

Bopanna

Ananthakrishnan

Kedia

et al. 2017

The Lancet Gastroenterology & Hepatology

165

104

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Summary Background The increased risk of colorectal cancer in ulcerative colitis is well known. The risk of sporadic colorectal cancer in Asian populations is considered low and risk estimates of colorectal cancer related to ulcerative colitis from Asia vary. This meta-analysis is an Asian perspective on the risk of colorectal cancer related to ulcerative colitis. Methods We searched PubMed and Embase for terms related to colorectal cancer in ulcerative colitis from inception to July 1, 2016. The search for published articles was done by country for all countries in Asia. We included studies with information on the prevalence and cumulative risk of colorectal cancer at various timepoints. A random-effects meta-analysis was done to calculate the pooled prevalence as well as a cumulative risk at 10 years, 20 years, and 30 years of disease. Findings Our search identified 2575 articles; of which 44 were eligible for inclusion. Our analysis included a total of 31 287 patients with ulcerative colitis with a total of 293 reported colorectal cancers. Using pooled prevalence estimates from various studies, the overall prevalence was 0·85% (95% CI 0·65–1·04). The risks for colorectal cancer were 0·02% (95% CI 0·00–0·04) at 10 years, 4·81% (3·26–6·36) at 20 years, and 13·91% (7·09–20·72) at 30 years. Subgroup analysis by stratifying the studies according to region or period of the study did not reveal any significant differences. Interpretation We found the risk of colorectal cancer in Asian patients with ulcerative colitis was similar to recent estimates in Europe and North America. Adherence to screening is therefore necessary. Larger population-based, prospective studies are required for better estimates of the risk.

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