Ulcerative colitis in China: Retrospective analysis of 3100 hospitalized patients

Wang, Yufang; Ouyang, Qi

doi:10.1111/j.1440-1746.2007.04873.x

Cited by 93 publications

(103 citation statements)

References 25 publications

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“…The incidence of IBD has been increasing in China in recent years. However, Chinese patients show somewhat different clinical patterns of IBD from those of their Western counterparts, such as a lower manifestation of fistulae and perianal diseases and a lower incidence of family history [14], which may be attributed to racial genetic predisposition, different cultural background, and dietary habits [15]. Consequently, there may be the seasonality of flares or births of IBD patients in China may show different patterns from those of IBD patients in Western countries.…”

Section: Introductionmentioning

confidence: 90%

Seasonality in Flares and Months of Births of Patients with Ulcerative Colitis in a Chinese Population

Bai

Guo

Shen³

et al. 2008

Dig Dis Sci

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Background and Aims Reports on seasonality in flares or months of births of inflammatory bowel disease patients have been inconsistent, but little data are available in a Chinese population. The aim of this study was to determine whether symptom flares and births of ulcerative colitis (UC) patients follow a seasonal pattern. Methods Patients with a diagnosis of UC established between January 1990 and December 2007 were investigated according to the occurrence of flares of symptoms and months of births. The expected flares or births were calculated on a monthly basis over the study period, taking into consideration the difference in the number of days in the month in each year. Results A total of 409 UC patients were included in the study, and 1030 flares of symptoms were determined. The peak number of flares occurred during the spring and summer, especially in June, while the nadir occurred in the winter, especially in January (v 2 (11 df) = 32.74304, P \ 0.005). The symptom flares also occurred more frequently in the spring-summer period than in the autumnwinter period (v 2 (3 df) = 22.1269, P \ 0.001). There was no statistical difference in birth distribution on a monthly or seasonal (spring, summer, autumn, winter) basis. However, the births of UC patients occurred more frequently in the autumn-winter period than in the spring-summer period when the data were merged into these two seasonal components (v 2 (1 df) = 5.255607, P \ 0.025). Conclusions The data indicate that the symptom flares of UC occurred more frequently in the spring and summer, while the births of UC patients occurred more often in the autumn and winter. Environmental recurring factors may be associated with the symptom flares of UC, and these factors during pregnancy or postpartum may be associated with susceptibility to UC later in life.

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Section: Introductionmentioning

confidence: 90%

Seasonality in Flares and Months of Births of Patients with Ulcerative Colitis in a Chinese Population

Bai

Guo

Shen³

et al. 2008

Dig Dis Sci

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“…In one study, the risk of Crohn's disease was significantly elevated (OR, 35; P < 0.05) if the patient smoked, had a sibling with Crohn's and carried at least two CARD15 genes [30] . In contrast, the average age of patients developing ulcerative colitis was older (mean 44 ± 15 years) and there are no large differences by gender [20] . Other risk factors for UC include prior smoking history (but not current smoking), family history of UC and high body weight (elevated BMI) [25] .…”

Section: Pathogenesismentioning

confidence: 76%

“…Crohn's disease results in inflammation, deep fistulas or abscesses anywhere along the gastrointestinal tract, but most commonly along the ileocolon. Colonoscopic examination of patients with ulcerative colitis shows pathology is limited to the large colon with surface inflammation and left-sided colitis, proctitis and proctosigmoiditis being most common [20] . Recent innovations in diagnostic techniques including noninvasive imaging techniques and more sensitive endoscopic equipment may improve the diagnosis of IBD.…”

Section: Diagnosismentioning

confidence: 99%

“…Variances in symptom types and frequency and a lack of structural abnormalities observed upon endoscopic examination typically may delay the diagnosis of IBD for 6 mo to 1 year [18] . The clinical presentation of Crohn's disease is abdominal pain, diarrhea and weight loss, while patients with UC most often complain of abdominal pain, bloody diarrhea and stool mucus [18,20] . Crohn's disease results in inflammation, deep fistulas or abscesses anywhere along the gastrointestinal tract, but most commonly along the ileocolon.…”

Section: Diagnosismentioning

confidence: 99%

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State-of-the-art of irritable bowel syndrome and inflammatory bowel disease research in 2008

McFarland¹

2008

WJG

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Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are two of the leading causes of chronic intestinal conditions in the world. This issue of World Journal of Gastroenterology (WJG ) presents a series of papers from world experts who discuss the current knowledge and opinions on these important conditions. Although great strides have been made in the diagnosis, treatment and pathology of IBS and IBD; much has yet to be explained. The etiologies and risk factors of these multifactorial conditions remain elusive. Specific diagnostic biomarkers need to be developed and safer treatments developed. The burden of IBS and IBD on the healthcare system is felt with repeated medical care visits and high costs. IBS and IBD patients can account for 30%-50% of office visits at gastroenterology services/clinics. Over one million people have IBD in the United States, with 30 000 new cases being diagnosed every year. One-quarter million people in the UK are afflicted with IBD. The cost of medical care in the United States for IBD is estimated to be $1.8 billion/year. IRRITABLE BOWEL SYNDROME (IBS)Incidence of IBS IBS is a global problem and is more common in women than men. In developed countries, the prevalence of IBS ranges from 3%-25% of adults [1][2][3][4] and in the United States, IBS affects 15 million adults [5] . In the United Kingdom, IBS affects 10%-15% of the adult population [6] . The cost of direct and indirect medical care for IBS reached over $200 billion dollars in the United States [5,7] . Diagnosis of IBSAs there are no biologic markers for IBS, the diagnosis is usually based on symptoms and exclusion of other known causes of intestinal distress [6] . Unlike IBD, IBS does not cause severe inflammation, ulcers or other structural damage that aids the diagnosis of IBD. IBS is a functional disorder characterized by abdominal bloating, flatulence, abdominal pain and bowel dysfunction. The varying nature of symptoms and lack of structural abnormalities presents a diagnostic challenge. There are three main types of disease phenotypes: diarrhea-predominant (IBS-D), constipation-predominant (IBD-C) or alternating diarrhea-constipation (IBS-A). The diarrhea-predominant type is more common (48%) in males, whereas constipation-predominant (39%) or alternating types (48%) are more common in women [1] . Several tools (for example, Rome Ⅲ, Manning criteria) have been developed to standardize the diagnosis of IBS. Most of the historic research has been focused on the pathophysiology of diarrhea, but constipation has not been as well described. The review by McCrea and colleagues in this issue summarizes our current knowledge about the physiology and pathology of constipation [8] . The prevalence of constipation ranges from 15%-25% in the general population and is more common in women than men and in ages over 70 years old [9] . The typical definition of constipation (less than three stools/week) may not be a sensitive measure for this condition, as individuals vary widely in their own bowel habits. ...

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“…The incidence of ulcerative colitis has been increasing in China in recent years (16), which is attributed to the improved hygiene events and the westernized lifestyle in urban population (17 Ag e -r e l a t e d o c c u r r e n c e o f u l c e r a t i v e c o l i t i s b y g e n d e r . T h e p e a k t i me o f o n s e t i n t h e ma l e u l c e r a t i v e c o l i t i s p a t i e n t s o c c u r s i n 2 0 -2 9 y e a r s o l d , c o mp a r e d wi t h 5 0 -5 9 y e a r s o l d o f t h e f ema l e p a t i e n t s , wh i l e t h e p e a k o f t o t a l p a t i e n t s i s b e t we e n 3 0 a n d 3 9 y e a r s o f a g (19), whereas the peak age is between 20 and 39 years in the Canadian population (20).…”

Section: Ulcerative Colitis and Crohn's Disease Are Collectively Refementioning

confidence: 99%

Gender-Related and City- and Countryside-Related Differences in Patients with Ulcerative Colitis in a Chinese Population

et al. 2008

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Ulcerative colitis in China: Retrospective analysis of 3100 hospitalized patients

Abstract: Compared with UC in Western countries, ulcerative colitis in China has some differences in clinical characteristics. Therefore, a further population-based epidemiological study is required to determine the prevalence and incidence rates of UC in China.

Cited by 93 publications

References 25 publications

Seasonality in Flares and Months of Births of Patients with Ulcerative Colitis in a Chinese Population

Seasonality in Flares and Months of Births of Patients with Ulcerative Colitis in a Chinese Population

State-of-the-art of irritable bowel syndrome and inflammatory bowel disease research in 2008

Gender-Related and City- and Countryside-Related Differences in Patients with Ulcerative Colitis in a Chinese Population

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