Ulcerative Colitis and Carcinoma Coli

Inflammatory Bowel Disease and Colon Cancer: A Review

“…The increased risk of colon cancer in UC is dependent on the duration and extent of dis ease [1][2][3]9], Patients with extensive (up to the hepatic flexure) or total colonic involve ment arc at greatest risk, with a significant increase in the incidence of colon cancer 8-10 years following the onset of symptoms. The cumulative incidence has been reported to be 5-10% at 20 years and 12-20% at 30 years [10][11][12][13], Most studies have shown that in patients with colitis confined to the left colon only (i.e.…”

Histomorphological features and prognosis of colitis-associated colorectal cancer in patients with primary sclerosing cholangitis

“…The remaining five cases were diagnosed after IBD diagnosis (median duration from IBD to PSC diagnosis: 30 years [range: 16-34]) but prior to CAC (median duration from PSC diagnosis to CAC: 8 years [range: [1][2][3][4][5][6][7][8][9][10][11][12][13][14]). Only two (of five, 40%) CACs invaded through the muscularis propria (T3) when PSC was found prior to the diagnosis of CAC, while all of six CACs invaded through the muscularis propria or beyond when PSC was diagnosed simultaneously with CAC (p = 0.06).…”

“…It is well established that patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer (CRC) [1][2][3][4]. While colitis-associated CRC (CAC) only contributes to 1-2% of cancer in general population, it is the cause of death in 15% of IBD patients [5].…”

The medical treatment of ulcerative colitis

“…Once total colonic involvement has occurred these children are just as susceptible to relapses and complications and to malignant change as are adults and because of the early onset of symptoms develop them at a very tender age (Rosenqvist et al, 1959).…”