UK Renal Registry 16th Annual Report: Chapter 15 Epidemiology of Reported Infections amongst Patients Receiving Dialysis for Established Renal Failure in England from May 2011 to April 2012: a Joint Report from Public Health England and the UK Renal Registry

Abstract

Introduction: Infection remains one of the leading causes of mortality in established renal failure patients receiving renal replacement therapy (RRT). Since 2007, centres providing RRT in England have been asked to provide additional data on patients with methicillin resistant Staphylococcus aureus (MRSA) bacteraemia. Since 2011, the option to provide data on methicillin sensitive Stapylococcus aureus (MSSA) and Escherichia coli bacteraemia, as well as Clostridium difficile infection has also been available. Methods: Data were submitted to Public Health England by laboratories via HCAI-DCS including whether the patients were receiving dialysis. Individual renal centres then confirmed the record either directly via the database or after being contacted. Data were collected for the period of the 1st May 2011 to the 30th April 2012. Results: There were 49 episodes of MRSA bacteraemia, an overall rate of 0.22 per 100 dialysis patients per year, representing a further year on year fall in MRSA rate. There were a higher number of MSSA episodes, 322 in total, with an overall rate of 1.15 per 100 dialysis patients per year. The number of episodes and overall rate of E. coli and C. difficile were 284 and 0.92 per 100 prevalent dialysis patients per year and 172 and 0.61 per 100 prevalent dialysis patients per year respectively. In each infection type the presence of a central venous catheter appeared to correlate with an elevated risk. Conclusions: Data are presented from one year of infections reported to PHE. The rate of MRSA bacteraemia episodes in England continues to fall. There was a higher rate of MSSA infections amongst renal dialysis patients. Findings from the first year of E. coli and C. difficile data collection are also reported. Future cycles will give us a further idea of the trend in incidences of these infections.Fax +41 61 306 12 34 E-Mail

UK Renal Registry 17th Annual Report: Chapter 12 Epidemiology of Reported Infections amongst Patients Receiving Dialysis for Established Renal Failure in England in 2012 to 2013: a Joint Report from Public Health England and the UK Renal Registry

“…This report has presented data from one year of infections in ERF patients receiving dialysis and extends the work done in previous reports from Public Health England and the UK Renal Registry [2]. Numbers and rates of MRSA BSIs in dialysis patients have fallen in each of the last six years this report has been published.…”

“…The previous report confirmed that whilst dialysis patients remained at increased risk from MRSA there has been a continued year on year decline in the number of reported episodes of bacteraemia [2].…”

“…In addition to staphylococcal bacteraemias, last year surveillance was expanded to incorporate E. coli BSIs and CDIs [2]. As well as the mandatory reporting of MRSA BSIs, reporting of MSSA has been mandated since January 2011 and E. coli BSIs since June 2011; CDI reporting has been mandatory for all patients aged two and above since 2007.…”

How I treat acute myeloid leukemia presenting with preexisting comorbidities

“…39 Furthermore, among chronic dialysis patients, asymptomatic carriers of resistant bacteria are prevalent. [40][41][42] A curative approach to AML may be futile among patients in whom the predicted survival due to their kidney disease is short even prior to the development of leukemia. 43,44 Realistic expectations and the desired goals of therapy must be discussed between the patient, family, nephrologist, and hematologist.…”

A Risk Assessment of Antibiotic Pan-Drug-Resistance in the UK: Bayesian Analysis of an Expert Elicitation Study

“…Numbers of PDR Gram-negative infections expected in each of these groups were estimated for each year subsequent to the scenario. Projected estimates of the annual number of patients were made using HES [26] for all groups apart from renal dialysis, which used data from the UK Renal Registry [27]. The incidences of Gram-negative infections for large bowel surgery, hip replacement surgery, and repair of fractured neck of femur were obtained from mandatory and voluntary surgical site infection (SSI) surveillance [28].…”