UK Management Practices in Stage I Seminoma and the Medical Research Council Trial of Imaging and Schedule in Seminoma Testis Managed with Surveillance

Cafferty, Fay; Gabe, Rhian; Huddart, Robert; Rustin, G. J. S.; Williams, M.; Stenning, Sally; Bara, Anna; Bathia, Riya; Freeman, Suzanne C.; Alder, Laura; Joffe, Johnathan

doi:10.1016/j.clon.2011.09.005

Cited by 30 publications

(12 citation statements)

References 45 publications

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“…In the United Kingdom (UK), a decrease of radiotherapy utilization has been observed to a similar extent as documented in Germany and also Scandinavia [29]. Currently, up to 66% of seminoma patients receive carboplatin chemotherapy in the United Kingdom; however, simultaneously, surveillance is gaining acceptance [30]. A recent report from Australia revealed that carboplatin was the most accepted treatment modality comprising about 62% of patients.…”

Section: Discussionmentioning

confidence: 93%

Seminoma Clinical Stage 1 - Patterns of Care in Germany

et al. 2016

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Introduction: International guidelines are ambivalent regarding the recommendations for the management of clinical stage 1 (CS1) seminoma. Patients and Methods: During 2008-2013, 1,050 patients with seminoma CS1 were prospectively registered with regard to assessing management modality (radiotherapy, carboplatin, surveillance). Associations with tumor size, rete testis invasion, age, year of diagnosis, type of institution, and geographic location were assessed. Results: Of the total number of patients, 49.3% received carboplatin 1 course, 8.5% carboplatin 2 courses, 35.9% surveillance, and 6.3% radiotherapy. In 2013, surveillance increased significantly to 57.9%. Treatment decisions were significantly associated with rete testis invasion and tumor size. Carboplatin was applied significantly more in office clinics than elsewhere. There is some regional variation regarding treatment preferences. Conclusions: The rising acceptance of surveillance mirrors international trends. The associations with prognostic factors demonstrate care givers to be compliant with contemporary guidelines. The association with the type of institution suggests non-oncological factors to be also relevant in decision making.

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Section: Discussionmentioning

confidence: 93%

Seminoma Clinical Stage 1 - Patterns of Care in Germany

et al. 2016

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“…Use of low-dose CT scans has lowered this risk. The ongoing Trial of Imaging and Surveillance in Seminoma Testis [27] comparing a reduced number of CT scans with magnetic resonance scans might add important information for the design of future follow-up programs. The use of abdominal ultrasound is currently not recommended in the follow-up of seminoma patients [2].…”

Section: Time To Relapse Yrmentioning

confidence: 98%

A Nationwide Cohort Study of Stage I Seminoma Patients Followed on a Surveillance Program

et al. 2014

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“…Finally, it is crucial to mention that the trial of imaging and schedule in seminoma of the testis (TRISST) is running, a large multicenter, randomized, prospective, non-inferiority trial with a factorial design including 660 patients. TRISST aims to compare the safety and effectiveness of MRI against CT for detecting retroperitoneal lymph nodes in patients with stage 1 testicular cancer [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance versus computed tomography for the detection of retroperitoneal lymph node metastasis due to testicular cancer: A systematic literature review

Ortiz

Beaujon

Villamizar

et al. 2021

European Journal of Radiology Open

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Introduction It is essential to see if MRI can be used as an alternative to CT for the detection of retroperitoneal lymphadenopathy in patients with testicular neoplasms. By doing so, the amount of radiation received by these young patients might be reduced. Material and methods A systematic literature review was carried out in 5 databases between January 1984 until December 2020. The articles included were randomized and non-randomized clinical trials, cross-sectional studies, cohort, case and control, and retrospective studies that compare the accuracy of MRI against CT to detect retroperitoneal lymph nodes in patients with testicular neoplasms. Results The search string initially retrieved 222 non duplicated papers from which a total of 3 studies of diagnostic accuracy were included for analysis. These articles evaluated a total of 127 patients with testicular neoplasm; the sample size per study ranged from 25 to 52 patients, with a mean age between 29–34 years. MRI presented a sensitivity ranging from 98−80% and specificity of 100 % when read by an experienced radiologist. However, when it was read by a radiologist with 1 year of experience, the sensitivity dropped to 78 % and specificity to 91%. Conclusion This systematic literature review shows a knowledge gap since not much has been published regarding this topic; therefore, randomized clinical trials are mandatory. Research on when to use MRI over CT is necessary to reduce radiation exposure. The authors strongly suggest that readers start researching on this subject.

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UK Management Practices in Stage I Seminoma and the Medical Research Council Trial of Imaging and Schedule in Seminoma Testis Managed with Surveillance

Cited by 30 publications

References 45 publications

Seminoma Clinical Stage 1 - Patterns of Care in Germany

Seminoma Clinical Stage 1 - Patterns of Care in Germany

A Nationwide Cohort Study of Stage I Seminoma Patients Followed on a Surveillance Program

Magnetic resonance versus computed tomography for the detection of retroperitoneal lymph node metastasis due to testicular cancer: A systematic literature review

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