UK health performance: findings of the Global Burden of Disease Study 2010

Murray, Christopher J L; Richards, M. A.; Newton, John; Fenton, Kevin; Anderson, Hugh; Atkinson, Charles; Bennett, Derrick; Bernabé, Eduardo; Blencowe, Hannah; Bourne, Rupert; Braithwaite, Tasanee; Brayne, Carol; Bruce, Nigel; Brugha, Traolach; Burney, Peter; Dherani, Mukesh; Dolk, Helen; Edmond, Karen; Ezzati, Majid; Flaxman, Abraham D.; Fleming, Tom D; Freedman, Greg; Gunnell, David; Hay, Roderick J.; Hutchings, Sally; Ohno, Summer Lockett; Lozano, Rafael; Lyons, Ronan A.; Marcenes, Wagner; Naghavi, Mohsen; Newton, Charles R.; Pearce, Neil; Pope, Daniel; Rushton, Lesley; Salomon, Joshua A.; Shibuya, Kenji; Vos, Theo; Wang, Haidong; Williams, Hywel C; Woolf, Anthony D.; Lopez, Alan D; Davis, Adrian

doi:10.1016/s0140-6736(13)60355-4

Cited by 491 publications

(282 citation statements)

References 49 publications

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“…Analogous mechanisms in asthma have not been explored in detail but, due to the inflammatory nature of both diseases, some of the aforementioned factors are also likely to play a role in asthma. Possible consequences for both diseases are very difficult to predict but one might speculate that the ageing processes may be reflected in shorter life expectancy and an increased risk of cognitive impairment and dementia as reported for asthma and COPD [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Telomere length in circulating leukocytes is associated with lung function and disease

Albrecht¹,

Sillanpää²,

Karrasch³

et al. 2013

European Respiratory Journal

106

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Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function.Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status.We observed negative associations between telomere length and asthma (b5 -0.0452, p50.024) as well as COPD (b5 -0.0982, p50.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p51.07610 -7 ), FVC (p52.07610 -5 ), and FEV1/FVC (p55.27610 -3 ). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients.Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases. @ERSpublicationsTelomere length is decreased in asthma and COPD patients and positively associated with spirometric indices

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Section: Discussionmentioning

confidence: 99%

Telomere length in circulating leukocytes is associated with lung function and disease

Albrecht¹,

Sillanpää²,

Karrasch³

et al. 2013

European Respiratory Journal

106

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“…Although Mediterranean countries (Spain and Italy) have lower levels of QoL [17], their populations have greater life expectancy and greater healthy life expectancy [20], as well as lower rates of suicide [21].…”

Section: Introductionmentioning

confidence: 99%

Quality of life in people aged 65+ in Europe: associated factors and models of social welfare—analysis of data from the SHARE project (Wave 5)

et al. 2016

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Purpose To analyse the clinical, sociodemographic and socioeconomic factors that influence perceived quality of life (QoL) in a community sample of 33,241 people aged 65+, and to examine the relationship with models of social welfare in Europe. Results In the multilevel analysis, greater satisfaction in life, less depression, sufficient income, better subjective health, physical activity, an absence of functional impairment, younger age and participation in activities were associated with better QoL in all countries. MethodsMore education was only associated with higher QoL in Eastern European and Mediterranean countries, and only in the latter was caring for grandchildren also related to better QoL.

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“…For example, for men aged 30-34, mortality rates fell by a mere 4%. 3 In all age groups under 55 years, the UK ranking in male age-specific mortality has worsened substantially compared to the 15 original members of the European Union, Australia, Canada, the USA and Norway. 19% of all male deaths were aged under 65 and 38% of all male deaths were aged under 75 in the UK in 2012.…”

Section: Wwwtrendsinmenshealthcom Trends In Urology and Men's Health mentioning

confidence: 99%

25 years post‐Calman: the state of men's health in the UK

Baker¹

2017

Trends Urol & Men's Health

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UK health performance: findings of the Global Burden of Disease Study 2010

Cited by 491 publications

References 49 publications

Telomere length in circulating leukocytes is associated with lung function and disease

Telomere length in circulating leukocytes is associated with lung function and disease

Quality of life in people aged 65+ in Europe: associated factors and models of social welfare—analysis of data from the SHARE project (Wave 5)

25 years post‐Calman: the state of men's health in the UK

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