Key messages• Standard treatment for hemophilia consists of prophylactic administration of a coagulation factor concentrate. This must be performed several times a week (intravenously).• Long-acting coagulation factor drugs can lengthen the time between treatments or increase coagulation factor levels.• New treatment options are based on new mechanisms of action and can be administered subcutaneously, sometimes with an extended half-life and a broad spectrum of application for hemophilia A, hemophilia B, and inhibitor hemophilia.• Emicizumab, which has already been authorized for use in Germany, significantly reduced hemorrhage rates in patients with hemophilia A, regardless of inhibitor status.• Long-term safety data and data on concomitant use of factor or bypass concentrates are still pending.• Clinical trials of gene therapy have been successful for both hemophilia A and hemophilia B. In some cases, normal coagulation factor levels have been achieved.