UK biotech sector loses flagship PowderJect to Chiron

Mitchell, Pete

doi:10.1038/nbt0703-717

Cited by 7 publications

(6 citation statements)

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“…Microfluidics is another strong driving force for the research on the dynamics of fluids on structured substrates. Shrinking standard laboratory setups to a lab-on-a-chip promises huge cost reduction and speed-up [17,18]. Open microfluidic systems, i.e., with free liquid-vapor or liquid-liquid interfaces, may provide various advantages such as reduced friction, better accessibility of the reactants, and reduced risk of clogging by solute particles [19,20,21,22].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of nanodroplets on topographically structured substrates

Moosavi

Rauscher

Dietrich

2009

J. Phys.: Condens. Matter

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Mesoscopic hydrodynamic equations are solved to investigate the dynamics of nanodroplets positioned near a topographic step of the supporting substrate. Our results show that the dynamics depends on the characteristic length scales of the system given by the height of the step and the size of the nanodroplets as well as on the constituting substances of both the nanodroplets and the substrate. The lateral motion of nanodroplets far from the step can be described well in terms of a power law of the distance from the step. In general the direction of motion depends on the details of the effective laterally varying intermolecular forces. But for nanodroplets positioned far from the step it is solely given by the sign of the Hamaker constant of the system. Moreover, our study reveals that the steps always act as a barrier for transporting liquid droplets from one side of the step to the other.

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Section: Introductionmentioning

confidence: 99%

Dynamics of nanodroplets on topographically structured substrates

Moosavi

Rauscher

Dietrich

2009

J. Phys.: Condens. Matter

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“…These microfluidic devices do not only allow for cheap mass production but they can operate with much smaller quantities of reactants and reaction products than standard laboratory equipments. This is particularly important for solutions containing rare and expensive substances, such as certain biological materials, and for toxic or explosive components [2]. Even though most microfluidic devices available today have micron sized channels, further miniaturization is leading towards the nano-scale [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…This is particularly important for solutions containing rare and expensive substances, such as certain biological materials, and for toxic or explosive components [2]. Even though most microfluidic devices available today have micron sized channels, further miniaturization is leading towards the nano-scale [2,3]. Besides meeting technical challenges, new § To whom correspondence should be addressed theoretical concepts are needed to understand the basic physical processes underlying this new technology [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Diffusive spreading and mixing of fluid monolayers

Popescu¹,

Dietrich²,

Oshanin³

2005

J. Phys.: Condens. Matter

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The use of ultra-thin, i.e., monolayer films plays an important role for the emerging field of nano-fluidics. Since the dynamics of such films is governed by the interplay between substrate-fluid and fluid-fluid interactions, the transport of matter in nanoscale devices may be eventually efficiently controlled by substrate engineering. For such films, the dynamics is expected to be captured by two-dimensional lattice-gas models with interacting particles. Using a lattice gas model and the non-linear diffusion equation derived from the microscopic dynamics in the continuum limit, we study two problems of relevance in the context of nano-fluidics. The first one is the case in which along the spreading direction of a monolayer a mesoscopic-sized obstacle is present, with a particular focus on the relaxation of the fluid density profile upon encountering and passing the obstacle. The second one is the mixing of two monolayers of different particle species which spread side by side following the merger of two chemical lanes, here defined as domains of high affinity for fluid adsorption surrounded by domains of low affinity for fluid adsorption.

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“…The PMED ® (Chiron Corporation) device, formerly known as PowderJect ® [302] has been reported to successfully deliver vaccines [303,304], lidocaine [305] and testosterone [306]. Dry powder formulations are generally more stable than solutions and may negate the need for the 'cold chain' to be maintained when using vaccines, for example.…”

Section: Jet Injectionmentioning

confidence: 99%

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

Morrow¹,

McCarron²,

Woolfson³

et al. 2007

TODDJ

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Abstact: Historically, the skin was thought to be a simple homogenous barrier. However, it is now known to be a highly specialised organ, and plays a key role in homeostasis. The protective properties of the skin are provided by the outermost layer, the epidermis, which safeguards against chemical, microbial, and physical attack. The exceptional barrier properties of the skin result in it being a challenging route for the delivery of therapeutic agents. This article reviews strategies developed to enhance the skin penetration of drugs, ranging from conventional approaches, for example the use of chemical penetration enhancers to those in early-stage development, such as microscissioning.

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UK biotech sector loses flagship PowderJect to Chiron

Cited by 7 publications

References 0 publications

Dynamics of nanodroplets on topographically structured substrates

Dynamics of nanodroplets on topographically structured substrates

Diffusive spreading and mixing of fluid monolayers

Innovative Strategies for Enhancing Topical and Transdermal Drug Delivery

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