UJI EFEKTIVITAS ANTIKOLESTEROL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalina Del.) DENGAN EKSTRAK ETANOL DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS HIPERKOLESTEROL

Abstract

African leaves (Gymnanthemum amygdalina Del.) and palm leaves (Elaeis guineensis Jacq.) which is contain flavonoid, saponin, alkaloid, and tannin can be used to decrease cholesterol levels and reduced the risk of cardiovascular disease. This study aims to determine the effect of EEDA dan EEDKS combination on blood cholesterol levels in hypercholesterolemic mice. Sample in this study was African leaves and palm leaves which were taken purposively without comparing samples from other regions, then extracted by maceration using ethanol 96%. The results of data analysis from the three EEDA and EEDKS groups effected cholesterol reduction due to the sig value <0.05. Based on ANOVA one way analysis of the five most effective treatments is simvastatin then dose 400-600mg/kgBB, dose 200-300mg/kgBB, dose 100-150mg/kgBB and CMC Na 1%. The combination of EEDA and EEDKS has an antihypercholesterol effect, the combination of EEDA and EEDKS has an antihypercholesterol effect that is comparable to the positive control, and the finding from this study that the most effective dosage of EEDA and EEDKS as antihypercholesterol is at dosage 400-600 mg/kgBB.

Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

“…mempunyai efek pada penurunan kadar kolesterol total pada tikus hiperkolesterol. Dosis pemberian dengan perbandingan 100-150 mg/KgBB, 200-300 mg/KgBB, dan 400-600 mg/KgBB selama 2 minggu (Sari et al, 2020). Studi lain pada model tikus dengan diabetes mellitus menunjukkan bahwa efek terapeutik kombinasi etanol dan ekstrak propolis dari Cina Utara mampu menyebabkan penurunan kadar glukosa darah, kolesterol total, trigliserida, kolesterol lipoprotein densitas rendah (LDL-C), dan kolesterol lipoprotein densitas sangat rendah (VLDL-C) dalam serum tikus puasa; dan untuk meningkatkan kadar serum kolesterol lipoprotein densitas tinggi (HDL-C) (Fuliang, et al, 2005).…”