UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH

Sari, Herviani; Kaban, Vera Estefania; Situmorang, Friska Raulina; Fahdi, Firdaus

doi:10.36656/jpfh.v2i1.79

Cited by 4 publications

(4 citation statements)

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“…This is what makes BGL rise, which is the cause of hyperglycemia. 10 Monitoring of BGLs is of important to diagnose diabetes mellitus. 9 Blood glucose levels can be evaluated when the patient is in a fasting state or when the patient comes to be checked, with the results of BGLs when >200 mg/dl, while the results of glucose levels when fasting are >126 mg/dl.…”

Section: Discussionmentioning

confidence: 99%

Impact of pharmacist counseling on the clinical outcomes in the management of type 2 diabetes mellitus outpatients admitted to a hospital

Rina,

Nasution,

Khairunisa

2023

Int J Basic Clin Pharmacol

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Background: Type 2 Diabetes mellitus remains a global health problem due to its poor clinical outcomes, high morbidity, and mortality caused by many complicated problems, one of which is the ineffective role of pharmacists in providing counselling to DM patients Methods: This pre and post cohort study analyzed the impact of pharmacist counselling on the blood glucose level and glycosylated hemoglobin (HbA1C) of T2DM outpatients (n=88) admitted to Asahan General Hospital period June to December 2022. Counselling provided comprised the importance of medication adherence and non-pharmacological approaches. Characteristics, BGLs and HbA1C of the patients were extracted from their medical records before and after counselling using a predetermined questionnaire. Characteristics of the patients were descriptively analyzed. Results: The significance of the counselling on these outcomes was analyzed by applying Wilcoxon test (p <0.05 was considered significant). The mean age of the patients was 57.89±9.75 (years). Most (57.95%) of them were female. Proportion of the patients with controlled BGLs (%): before counselling, 27.7; after counselling, 89.8. Proportion of the patients with controlled HbA1C (%): before counselling, 27.3; after counselling, 89.8. Pharmacist counselling significantly improved the clinical outcomes of T2DM patients, p=0.000. Conclusions: Pharmacist counselling plays an important role to improve BGLs and HbA1C in T2DM patients which can finally improve their quality of life.

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Section: Discussionmentioning

confidence: 99%

Impact of pharmacist counseling on the clinical outcomes in the management of type 2 diabetes mellitus outpatients admitted to a hospital

Rina,

Nasution,

Khairunisa

2023

Int J Basic Clin Pharmacol

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“…The fresh leaves of the D. pentandra are sorted, thoroughly washed, drained, and then air dried to dry. D. pentandra powder was extracted by the maceration method, soaking the sample in 96% ethanol for 5 days, re-macerating for 2 days, filtering, and then concentrating with a rotary evaporator to obtain a thick extract [7], [8].…”

Section: Methods 21mentioning

confidence: 99%

The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats

Syafitri¹,

Yuandani²,

Widyawati³

2023

International Journal of Science, Technology & Management

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Dendrophthoe pentandra (L.) Miq is a parasitic plant with medicinal potential found in 3000 other plant species. The duku parasite is usually considered a parasite on the duku plant and is often discarded because it is thought to interfere with the growth of the duku plant. The purpose of this study was to see the effect of the duku parasite leaf extract on the reduction of malondialdehyde (MDA) in hyperglycemic rats. MDA levels were measured by thiobarbituric acid-reactive substance (TBARS) assay with doses of duku mistletoe leaf ethanol extract of 400, 200, and 100 mg/kg BW. MDA levels were analysed using rat blood plasma, which was measured using a spectrophotometer at a wavelength of 532 nm. Oral administration of EEDBD 400, 200, and 100 mg/kg BW reduced MDA levels in hyperglycemic rats. However, only EEDBD 400 mg/kg BW showed a significant difference between the negative control (CMC-Na), but with glibenclamide and the normal groups, there was no significant difference.

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“…Simplisia dari rimpang temu kunci direndam dengan etanol 96% selama 5 hari, disaring residu diremaserasi dengan menggunakan pelarut etanol 96% selama 2 hari. Filtrat 1 dan 2 yang sudah dicampur dipekatkan hingga kental dengan menggunakan rotary evaporator (Sari et al, 2019).…”

Section: Pembuatan Ekstrakunclassified

Uji Aktivitas ALT, AST dan Histopatologi Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia rotunda (L.) Mansf) pada Tikus Putih Jantan

Harahap,

Sitorus

2023

jharma

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Experimental research in the field of hepatology on the development of traditional medicine into a potential pharmacological solution to protect the liver from cirrhosis. Accordingly, this study investigated the effect of ethanol extract of temu kunci rhizome on liver cirrhosis. The rats were divided into six groups, the normal control group was given nothing but pellets and sufficient water, the negative control group was given orally CMC-Na 0.5%, 200 mg acetylcysteine (dose converted to rat) was given to the positive control group, and the treatment group was given ethanol extract of temu kunci rhizome doses of 250, 500, 750 mg/kg BW, given daily for 10 days. Then on the 10th day after 1 hour of extract administration, induction was carried out with paracetamol 800 mg/kg BW orally; 16 hours after induction, rats were sacrificed, blood was taken for ALT and AST enzyme examination, then liver organs were taken for histopathological examination. The administration of ethanol extract of temu kunci rhizome can prevent liver damage by reducing ALT and AST enzyme levels in rat blood serum. The best dose in reducing ALT and AST enzymes was produced by giving 500 mg/kg BW of temu kunci rhizome ethanol extract every day for 10 days. At a dose of 500 mg/kg BW ethanol extract of temu kunci rhizome morphologically (evaluation with H&E staining) can also repair liver tissue damaged by paracetamol induction. The development of liver damage can be interpended by using ethanol extract of temu kunci rhizome, so that the status of liver morphology, structure and function of the liver can be maintained.

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UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH

Cited by 4 publications

References 0 publications

Impact of pharmacist counseling on the clinical outcomes in the management of type 2 diabetes mellitus outpatients admitted to a hospital

Impact of pharmacist counseling on the clinical outcomes in the management of type 2 diabetes mellitus outpatients admitted to a hospital

The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats

Uji Aktivitas ALT, AST dan Histopatologi Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia rotunda (L.) Mansf) pada Tikus Putih Jantan

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