Plants with various varieties can be found in various regions in Indonesia. Many varieties of medicinal plants in Indonesia have been used as raw materials to manufacture drugs. Some of these plants have been clinically evaluated for their phytochemical composition, efficacy, and safety to use. Bidara leaves, scientifically known as Zizhipus mauritiana L., are often used in Traditional Chinese Medicine to treat several ailments, such as urinary problems, indigestion, fever, liver complaints, weakness, anemia, obesity, diabetes, bronchitis, skin infections, loss of appetite, eating, pharyngitis, diarrhea, cancer, and insomnia. Reference libraries obtained from the search results are then studied and examined to determine research findings, then described using data or samples collected. From research and literature studies, bidara leaves have many uses, namely, as an anti-microbial agent, an analgesic, antipyretic, anti-inflammatory, and anti-cancer, and can protect body cells such as the kidneys and brain from oxidative stress, which can cause cancer.