Uji Efek Kombinasi Eeds Dan DPW Terhadap Penurunan Kadar Kolesteroltotal Dan Glukosa Darah Tikusputih Jantan Hiperkolesterolemia-Diabetes

Tandi, Joni; Na'i, Alpina; Basilingan, Aprince

doi:10.35799/pmj.2.1.2019.23607

Cited by 4 publications

(5 citation statements)

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“…Ekstrak gabungan dari hibiscus sabdariffa, zingiber officinale dan piper nigrum memiliki potensi untuk mengobati hiperglikemia dan memperbaiki parameter hematologi pada tikus dengan diabetes induksi aloksan (Franklin Ani, et al, 2022). Ekstrak etanol daun sirsak dan ekstrak etanol daun pandan wangi dapat menurunkan kadar kolesterol total dan glukosa darah pada tikus putih jantan hiperkolesterolmia-diabetes (Tandi et al, 2019). Hasil penelitian lain dengan mixed eksperimen, yaitu pemberian ekstrak etanol daun afrika (Gymnanthemum amygdalina Del.)…”

Section: Pendahuluanunclassified

Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

Kasimo,

Savitri,

Kadir

et al. 2023

j.kesehatan metro sai wawai

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Latar Belakang: Sindrom metabolik merupakan salah satu masalah kesehatan yang meningkat saat ini. Sindrome metabolik akan meningkatkan risiko diabetes melitus tipe 2 dan kardiovaskuler. Penyakit ini menjadi ancaman kesehatan sehingga dibutuhkan kombinasi obat dalam menangani berbagai gangguan disfungsi. Terapi obat kimia tidak cukup menyembuhkan atau menghentikan perkembangan penyakit. Tanaman Rosella dan pare memiliki aktifitas sebagai hipoglikemik dan antilipidemik. Tujuan: Untuk mengetahui efek kombinasi ekstrak rosella dan pare dalam menurunkan kadar glukosa darah puasa dan meningkatkan kadar HDL terhadap tikus model sindrom metabolik. Metode: Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan sampel penelitian dibagi dalam 5 kelompok perlakuan. Analisis data dengan uji paired T Test. Tahapan pelaksanaannya yaitu pengkondisian tikus sindrom metabolik. Hasil: Pada kelompok PII didapatkan penurunanan kadar glukosa darah puasa yang signifikan setelah intervensi sebesar 37,43 % (p value = 0,001). Pada kelompok PII didapatkan peningkatan kadar HDL yang signifikan setelah interveni 48,95 % (p value = 0,005) Simpulan: Potensi kombinasi pemberian ekstrak rosella dan pare mampu menurunkan kadar glukosa darah puasa dan meningkatkan kadar HDL tikus model sindrom metabolik. Simpulan: Kadar glukosa darah puasa tikus model sindrom metabolik menurun dan kadar HDL meningkat setelah diberikan intervensi kombinasi ekstrak rosella dan pare. Tahap lanjutan studi adalah untuk mengetahui uji toksisitas akut penggunaan rosella dan pare. Abstract: The potency of Combination of Rosella and Bitter Gourd Extracts to Reduce Blood Glucose Levels and Increase HDL-Cholesterol in Metabolic Syndrome Model Rats. Background: Metabolic syndrome is one of the increasing health problems today. The metabolic syndrome will increase the risk of type 2 diabetes mellitus and cardiovascular disease. This disease is a health threat that requires a combination of drugs to treat various dysfunction disorders. Chemical drug therapy is not enough to cure or stop the progression of the disease. Rosella and bitter melon plants have activities as hypoglycemic and antilipidemic. Purposes: To determine the effect of a combination of rosella and bitter melon extracts in reducing fasting blood glucose levels and increasing HDL levels in metabolic syndrome model rats. Methods: The research design used was a completely randomized design (CRD) with the research sample divided into 5 treatment groups. Data analysis with paired T-test. The stages of implementation are conditioning of metabolic syndrome rats. Result: In group PII, there was a significant decrease in fasting blood glucose levels after intervention by 37.43% (p-value = 0.001). In group PII, there was a significant increase in HDL levels after the intervention of 48.95% (p-value = 0.005) Conclusion: After receiving a mixture of rosella and bitter melon extracts, rats with the metabolic syndrome model had lower fasting blood glucose levels and higher levels of HDL. The next stage of the study was to determine the acute toxicity test of using rosella and bitter melon.

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Section: Pendahuluanunclassified

Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

Kasimo,

Savitri,

Kadir

et al. 2023

j.kesehatan metro sai wawai

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“…The ethanol extract of fruit flesh also showed activity in lowering blood glucose levels, low density lipoprotein (LDL), triglycerides, and increasing high density lipoprotein (HDL) in alloxan-induced animal models (Tandi et al, 2019).…”

Section: Page152mentioning

confidence: 99%

Effectiveness of Combination of Tamarind and Saffron as Antidiabetic

Hilda

Nasution

2021

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<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p><em>According to the International Diabetes Federation, 537 million people are currently living with diabetes. There are 316 million people with impaired glucose tolerance at high risk, an alarming number expected to reach 783 million people by 2045. Society's tendency to return to nature is a prospective condition for developing research on biodiversity-based plants. Based on the research results, tamarind leaves are rich in flavonoids, saponins, and tannins, and saffron contains the active compounds crocin, crocetin, and precision, which can be candidates for antioxidants that have a significant effect on blood glucose levels. This antidiabetic research includes research live (test animals) by measuring blood glucose levels. The results showed that tamarind leaf extract and saffron were effective as antidiabetics in male mice induced with Streptozotocin. All extract groups tested single doses of EDAJ, ES, and combination doses of EDAJ and ES ((75:25), (50:50) (25:75)) showed the potential to reduce blood sugar levels >50%. The ES group with a single dose of 100:0 showed significant effectiveness in reducing blood sugar levels from the 6th day until the end of the study. These results are then expected to provide information to the public regarding the potency, effective dose, and working mechanism of using tamarind and saffron as antidiabetics so that they can be a solution to improve the quality of life of diabetes patients, control non-communicable diseases and reduce treatment costs</em>. </p><p> </p></td></tr></tbody></table></div><strong><em>Keywords: Crocus sativus, Diabetes mellitus, Mus musculus, Saffron, Tamarind leaf</em></strong><em> </em>

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“…Hal ini disebabkan karena obat glibenklamid memiliki mekanisme kerja merangsang sekresi insulin, sehingga ia hanya dapat menurunkan kadar glukosa darah tetapi glibenklamid tidak dapat meregenerasi sel beta pankreas. Hal iniah yang menyebabkan kontrol positif tidak menimbulkan efek terapi dalam meregenerasi sel beta pankreas (17,18) .…”

Section: Hasil Dan Pembahasanunclassified

“…Hasil perbandingan dengan penilitian terdahulu yaitu pada ekstrak etanol daun kenikir pada dosis 400 mg/kg BB memiliki efek terhadap meregenerasi sel β pankreas dengan nilai rata-rata kerusakan 0,25 15 . Uji efek ekstrak etanol daun kemangi pada dosis 800 mg/kg BB memiliki efek terhadap regenerasi sel β pankreas dengan rata-rata kerusakan 0,2 17 . Penelitian lain juga menyatakan ekstrak etanol daun jambu air pada dosis 300 mg/kg BB efektif dalam meregenerasi sel β pankreas dengan rata-rata kerusakan 1,3 (19) .…”

Section: Untuk Melihat Perbedaan Yang Bermakna Antar Kelompok Perlakuan Dilanjutkan Dengan Ujiunclassified

Uji Potensi Ekstrak Daun Benalu Batu (Begonia Sp) Terhadap Kadar Glukosa Dalam Darah Dan Gambaran Histopatologi Pankreas Tikus Putih Jantan (Rattus Norvegicus)

Tandi¹,

Paerunan²,

Nurifa³

et al. 2020

j. ilm. manuntung sains farm. kesehat.

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This study aims to determine the potential for glucose levels in the blood of ethanol extracts of the begonias (Begonia Sp.), the effect of the extract on the pancreatic histopathology of white rats (Rattus norvegicus) which was induced by streptozotocin, and the effective dose begonias’ extract leaves on the histopathological descriptions of pancreatic male white rats. This study was an experimental laboratory where the research group consisted of group I (the control group) as a normal control was given a standard feed, group II (negative control) was given a 0.5% Na CMC suspension, group III (positive control) was orally given glibenclamide and experimental groups IV, V, and VI (doses 50, 100, and 200 mg/kg BW). Were given ethanol extract of begonias leaves. The results showed that the ethanol extract of the begonias (Begonia Sp.) contained secondary metabolite compounds, namely flavonoids, alkaloids, saponins, polyphenols, and tannins. Ethanol extract of begonias leaves at adose of 50 mg/kg BW was an affective dose in reducing blood glucoselevels by an avarage of 101,8 mg/dL) and a dose of 50 mg/kg BW can affect the histopathological picture of the pancreas in STZ induuced rats with an average damage value of 2 from a maximum of 4.

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Uji Efek Kombinasi Eeds Dan DPW Terhadap Penurunan Kadar Kolesteroltotal Dan Glukosa Darah Tikusputih Jantan Hiperkolesterolemia-Diabetes

Cited by 4 publications

References 0 publications

Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik

Effectiveness of Combination of Tamarind and Saffron as Antidiabetic

Uji Potensi Ekstrak Daun Benalu Batu (Begonia Sp) Terhadap Kadar Glukosa Dalam Darah Dan Gambaran Histopatologi Pankreas Tikus Putih Jantan (Rattus Norvegicus)

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