UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa Bilimbi Linn) TERHADAP BAKTERI Staphylococcus aureus

Ferdyani, Shelvi; Yuniarto, Prayoga Fery

doi:10.30737/jumakes.v2i1.1219

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…The mechanism of action of saponins in inhibiting bacterial growth is by interfering with the surface tension of the cell wall by diffusing through the outer membrane and cell wall and then binding to the cytoplasmic membrane. This activity causes the cytoplasm to leave the cell and cell lysis occurs [15,16] . The active compounds of flavonoids form complexes with bacterial proteins through hydrogen bonds which result in the structure of the cell wall and the bacterial cytoplasmic membrane becoming unstable.…”

Section: Discussionmentioning

confidence: 99%

Extract wuluh starfruit (Averrhoa bilimbi L.) potentiate the effect of antibacterial against Porphyromonas gingivalis

Wahyukundari,

Izdihar,

Praharani

2023

Int. J. Appl. Dent. Sci.

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Background: Periodontitis is a problem in dental and oral health with a high prevalence in Indonesia of 74.1%. Porphyromonas gingivalis was found in 85.75% of the subgingival plaque of periodontitis patients. Metronidazole is often used as adjunctive therapy to provide maximum results in the treatment of periodontitis but is contraindicated in certain patients. The wuluh starfruit has been shown to have active compounds including tannins, saponins, alkaloids, and flavonoids as well as vitamins that are antibacterial. This study aimed to analyze the antibacterial power of wuluh starfruit extract on the growth of P. gingivalis at concentrations of 6.25%, 12.5%, 25%, 50%, and 100%. Methods: This type of research is an experimental laboratory with the post-test only control group design. Antibacterial test using disc diffusion method. This study consisted of 5 treatment groups (concentration of wuluh starfruit extract 6.25%, 12.5%, 25%, 50%, and 100%) and 2 control groups (negative control group and positive control group). Results:The research data in the form of the diameter of the inhibition zone were analyzed by the Kruskal Wallis test followed by the Mann-Whitney test with the results that there were significant differences. Conclusions: Based on the research, it can be concluded that the extract of wuluh starfruit (Averrhoa bilimbi L.) at concentrations of 6.25%, 12.5%, 25%, 50%, and 100% had antibacterial activity against the growth of P. gingivalis, the smallest at a concentration of 6.25% and the largest at a concentration of 100%.

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Section: Discussionmentioning

confidence: 99%

Extract wuluh starfruit (Averrhoa bilimbi L.) potentiate the effect of antibacterial against Porphyromonas gingivalis

Wahyukundari,

Izdihar,

Praharani

2023

Int. J. Appl. Dent. Sci.

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“…In vitro, testing of Putri Malu leaves extract against five microorganisms showed high activity at 100% concentration against Staphylococcus aureus, Enterobacter cloacae, Staphylococcus aureus, Escherichia coli, and Proteus stuarti [25]. Anggita et al (2018) discovered that ethanol extract of Putri Malu leaves had antibacterial activity against Staphylococcus aureus bacteria at a concentration of 10% and an inhibitory zone diameter of 1.01 mm [29].Honey has been shown to have an antimicrobial impact in expediting wound healing.…”

Section: 4mentioning

confidence: 99%

Phytochemical Screening And Antibacterial Activity Of The Ethanol Extract Of Putri Malu (Mimosa Pudica Linn.) Leaves Combined With Klanceng Honey Against Staphylococcus Aureus Bacteria

Dalimunte,

Arianto,

Salim

2023

International Journal of Science, Technology & Management

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Mimosa pudica Linn. Leave and honey have been known to have antibacterial activity. The combination of the two is very beneficial as an antibacterial because the hydrogen peroxide content in honey and the flavonoid metabolite compounds in Putri Malu provide a synergistic effect as an antibacterial. The aim of this research was to determine the activity of the ethanol extract of Putri Malu leaves combined with Klanceng honey using the disc diffusion method against Staphylococcus aureus bacteria. The results showed that the resulting extract was thick and blackish-green in colour, with a yield of 25.6%. The results of the phytochemical screening test showed that Putri Malu extract contains alkaloids, flavonoids, glycosides, saponins, and tannins. Characterization results showed that the water content of the extract was 7.28 ± 0.05, water-soluble essence content was 16.03 ± 0.08, ethanol-soluble essence content was 19.65 ± 0.01, total ash content was 4.70 ± 0.00, and essence content acid soluble was 0.17±0.02. Antibacterial testing showed that the best ratio of Putri Malu leaf extract to honey to inhibit Staphylococcus aureus was 9:1, with an inhibitory value of 13.60 ± 0.40 mm. In conclusion, the combination of Putri Malu leaf extract with honey strongly inhibits the growth of Staphylococcus aureus bacteria.

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“…Propilenglikol berfungsi sebagai humektan yang akan menjaga kestabilan sediaan gel, mempertahankan kandungan air dalam sediaan sehingga sifat fisik sediaan selama penyimpanan dapat dipertahankan. Metil paraben berfungsi sebagai pengawet karena sediaan gel memiliki kandungan air yang tinggi yang dapat menyebabkan terjadinya kontaminasi mikroba [16].…”

Section: Hasil Evaluasi Sediaan Gelunclassified

“…Uji daya sebar bertujuan untuk mengetahui daya penyebaran gel pada kulit yang sedang diobati.. Hasil uji daya sebar menunjukan sediaan gel memenuhi persyaratan parameter daya sebar sediaan semi padat yaitu 5-7 cm [16].…”

Section: Hasil Uji Daya Sebarunclassified

FORMULASI DAN UJI AKTIVITAS GEL EKSTRAK ETANOL 96% DAUN BELIMBING WULUH (Averrhoa bilmbi Linn) TERHADAP BAKTERI Staphylococcus epidermidis

Ismail

2022

INA RESEARCH PHA

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Daun belimbing wuluh (Averrhoa bilimbi Linn) mengandung senyawa metabolit sekunder yaitu flavonoid dan tanin yang dapat digunakan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri pada sediaan gel ekstrak etanol daun belimbing wuluh dengan konsentrasi 30%, 35% dan 40%. Daun belimbing wuluh yang sudah diserbukan kemudian di ekstraksi dengan metode maserasi menggunakan etanol 96% kemudian diuapkan dengan oven sampai menjadi ekstrak kental. Uji aktivitas antibakteri pada gel daun belimbing wuluh menggunakan difusi cakram terhadap bakteri Staphylococcus epidermidis dengan mengukur zona hambat pertumbuhan bakteri. Formulasi sediaan gel ekstrak etanol daun belimbing wuluh yaitu F1 30%, F2 35% dan F3 40%, kontrol negatif (Aquadest steril) dan control positif (Klindamisin disk). Evaluasi sediaan gel meliputi uji organoleptis, homogenitas, pH, daya sebar, dan viskositas. Pada hasil penelitian didapat bahwa ekstrak etanol 96% daun belimbing wuluh yang diformulasikan dalam bentuk sediaan gel memiliki antibakteri terhadap Staphylococcus epidermidis dan memberikan zona hambat terbesar pada konsentrasi 40% dibandingkan dengan gel konsentrasi 30% dan 35%.

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UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa Bilimbi Linn) TERHADAP BAKTERI Staphylococcus aureus

Cited by 3 publications

References 3 publications

Extract wuluh starfruit (Averrhoa bilimbi L.) potentiate the effect of antibacterial against Porphyromonas gingivalis

Extract wuluh starfruit (Averrhoa bilimbi L.) potentiate the effect of antibacterial against Porphyromonas gingivalis

Phytochemical Screening And Antibacterial Activity Of The Ethanol Extract Of Putri Malu (Mimosa Pudica Linn.) Leaves Combined With Klanceng Honey Against Staphylococcus Aureus Bacteria

FORMULASI DAN UJI AKTIVITAS GEL EKSTRAK ETANOL 96% DAUN BELIMBING WULUH (Averrhoa bilmbi Linn) TERHADAP BAKTERI Staphylococcus epidermidis

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