UHPLC-MS/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of Polygala tenuifolia in rat plasma

Abstract

(2020) UHPLC-MS/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of

3,6'‐disinapoyl sucrose attenuates Aβ1‐42‐ induced neurotoxicity in Caenorhabditis elegans by enhancing antioxidation and regulating autophagy

“…55 However, the absorption of DISS could be promoted by multiple conditions, such as other ingredients in Polygalae Radix, compatibility with other herbs, 56 disease state 57 and processing procedure. 53 In addition, brain distribution research of DISS is limited. A report mentioned that DISS could distribute into brain (~7 ng/g) when rats…”

“…Although the pharmacokinetics of DISS in C . elegans is not obvious, many studies reported that DISS was absorbed into blood very quick when rats were orally administered DISS, Polygalae Radix or compound containing Polygalae Radix 53,54 . However, the bioavailability of DISS in rats was not very high and it was eliminated from blood, and brain is also very quick because oligosaccharide esters could be hydrolysed to secondary glycosides or aglycones 55 .…”

“…However, the bioavailability of DISS in rats was not very high and it was eliminated from blood, and brain is also very quick because oligosaccharide esters could be hydrolysed to secondary glycosides or aglycones 55 . However, the absorption of DISS could be promoted by multiple conditions, such as other ingredients in Polygalae Radix, compatibility with other herbs, 56 disease state 57 and processing procedure 53 . In addition, brain distribution research of DISS is limited.…”

Ácido 3,4,5-Trimetoxicinâmico e seu Potencial Terapêutico: Uma Revisão / 3,4,5-Trimethoxycinnamic Acid and Its Therapeutic Potential: A Review

“…Brazilian Journal of Development, Curitiba, v.7, n.11, p. 104656-104670 nov. 2021 Zhao et al (2020) estabeleceram um método UHPLC-MS/MS para detectar simultânea e quantitativamente a sibiricose A5, sibiricose A6, 3,6′-disinapoil sacarose, tenuifolisideo A e TMCA (compostos presentes nas raízes de Polygala tenuifolia Wild) em plasma de rato. Este estudo não só determinou os níveis de TMCA nas raízes da planta crua, mas também em raízes fervidas com alcaçuz e também do cozimento de mel, pois este tipo de processamento é comumente utilizado na prática clínica chinesa.…”

Measurement and Analysis of Solvent Behavior and Thermodynamic Properties of 3,4,5-Trimethoxycinnamic Acid in Industrial Common Solvents with Different Temperatures (T = 278.15–323.15 K)

“…11 Processing technology can promote the bioavailability of TMCA and provide scientific basis for future clinical application and processing mechanism. 12 In the pharmaceutical industry, especially in the purification, crystallization, and other processes, accurate solubility data for improving the recovery rate and product quality is of great significance. However, the solubility of TMCA was much lower in some solvents, which limited its industrial application.…”