UHPLC-HRMS profile and accumulation of argentatins in stems of 27 accessions of guayule (Parthenium argentatum A. Gray) and its hybrids along the growth cycle

Gallego, Beatriz; Carrión, M. Engracia; Latorre, Guayente; García-Martínez, M. Mercedes; Mendoza, Jorge Hurtado de; Zalacaín, Amaya; Carmona, Manuel

doi:10.1016/j.indcrop.2022.115463

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…In terms of leaf production per hectare, irrigation yields a higher content than non-irrigation. Through comparing the results of argentatins and isoargentatins obtained in leaves with their content in guayule stems [ 19 ], it is evident that the values obtained for the same accessions by Gallego and colleagues are much higher. Nonetheless, if the same accessions are compared with the stems of plants of the same age and under the same conditions [ 20 ], the contents of aA and aB are very similar.…”

Section: Discussionmentioning

confidence: 99%

“…Beyond the commercialization of the guayulins, a large number of other extractable secondary metabolites that could be economically exploited are present in relevant amounts in guayule stem resin, including triterpenes and their derivatives, known as the argentatins. Recently, Gallego et al [ 19 ] identified, for first time, the argentatins and derivates profile in 27 different guayule accessions with LC-CR-MS technology (Orbitrap ® ). There is limited information on argentatin accumulation as their routine quantification is challenging because the structure lacks double bonds and shows a weak chromophoric functionality; however, Gallego et al [ 20 ] recently proposed their quantification using a refractive index detector after their chromatographic separation.…”

Section: Introductionmentioning

confidence: 99%

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Argentatin Content in Guayule Leaves (Parthenium argentatum A. Gray)

García-Martínez

Gallego

Latorre

et al. 2023

Plants

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Approximately one-third of the waste biomass from the cultivation of guayule (Parthenium argentatum A. Gray) for natural rubber production is leaf tissue; however, whether it can be valorized is not known. Guayulins and argentatins are potential high-value products that can be recovered from guayule resin during rubber/latex processing. Argentatins are highly abundant in guayule stem resin; however, unlike the guayulins, their occurrence in leaves has not been investigated. The present study determined the content of argentatins and isoargentatins A and B in the leaves of a pure guayule accession (R1040) and two hybrids (CAL-1 and AZ-2) under conditions of irrigation and non-irrigation. The resin content in leaves was ~10%, which provides a suitable starting point for economic exploitation. The highest production of argentatins occurred in plants under irrigation, with yields of 4.2 and 3.6 kg ha−1 for R1040 and AZ-2, respectively. The R1040 accession had the highest percentage of resin and the greatest total argentatin content (24.5 g kg−1 dried leaf), principally due to the abundance of argentatin A. Contrastingly, CAL-1 consistently showed the lowest argentatin content based on dried leaf weight and production (0.6 kg ha−1). The substantial abundance of argentatins in guayule leaves suggests the potential for future exploitation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Argentatin Content in Guayule Leaves (Parthenium argentatum A. Gray)

García-Martínez

Gallego

Latorre

et al. 2023

Plants

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“…In addition to its use in the manufacture of hypoallergenic latex, several secondary metabolites isolated from guayule have received increasing attention in recent years due to their unique structural characteristics and biological properties. The most important of these are the argentatins, which are the principal secondary metabolites of guayule resin, accounting for approximately 30% of the total resin obtained from this shrub [2]. Argentatins are cycloartane-type triterpene compounds with diverse pharmacological properties, including antimicrobial and anticarcinogenic activity in vitro.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory activity of argentatins A and B isolated from guayule

Silva-Nolasco,

de la Cruz-Morcillo,

García-Martínez

et al. 2024

PLoS ONE

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Argentatins are secondary metabolites synthesized by guayule (Parthenium argentatum A. Gray) with numerous potential medical applications. In addition to inhibiting insect growth, they are endowed with several pharmacological properties including antimicrobial and antitumorigenic activity. However, their potential as immunomodulators remains unexplored. The aim of the present study was to investigate whether argentatins can modulate the function of the immune system. Human mesenchymal stem cells were treated with argentatins and the production of several anti- and proinflammatory cytokines was evaluated. The effect of argentatins on the polarization of CD4+ T-lymphocytes and macrophages was also assessed. Results demonstrated that argentatins can modulate the production of proinflammatory cytokines and the polarization of cellular phenotypes, including Th2 lymphocytes and M1 macrophages. These findings suggest that argentatins are promising therapeutic agents in autoimmune or allergic diseases, and open new perspectives for the investigation of argentatins in immune response and in the development of more targeted and effective immunomodulatory therapies.

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