UGT1A1 genotype influences clinical outcome in patients with intermediate-risk acute myeloid leukemia treated with cytarabine-based chemotherapy

Díaz-Santa, Johana; Rodríguez-Romanos, Rocío; Osca, Gemma; Pratcorona, Marta; Garrido, Ana; Coll, Rosa; Moret, Carla; Escoda, Lourdes; Tormo, Mar; Heras, Inma; Arnan, Montse; Vives, Susanna; Salamero, Olga; Lloveras, Natàlia; Bargay, Joan; Sampol, Antònia; Cruz, David; Garcia, Antoni; Quiñones, Teresa; Esteve, Jordi; Sierra, Jorge; Gallardo, David

doi:10.1038/s41375-020-0784-2

Cited by 10 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Díaz-Santa et al. found that AML patients carrying the UGT1A1*28 purity variant, linked to reduced UGT1A1 activity, exhibited lower overall survival rates ( 29 ). Unexpectedly, the findings of Díaz-Santa and colleagues contradict those reported by Chen and team.…”

Section: Discussionmentioning

confidence: 99%

Genetic prediction of causal association between serum bilirubin and hematologic malignancies: a two-sample Mendelian randomized and bioinformatics study

Lu,

Luo,

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

IntroductionAn increasing number of cohort studies have shown a correlation between serum bilirubin and tumors, but no definitive causal relationship has been established between serum bilirubin and hematological malignancies.Therefore, the aim of the present study was to assess the causal relationship of serum bilirubin, including total bilirubin (TBIL) and direct bilirubin (DBIL), with hematological malignancies, including leukemia, lymphoma, and myeloma.MethodsWe used a genome-wide association study (GWAS) collection of TBIL, DBIL, and hematological malignancies data. Using two-sample Mendelian randomization(MR), we assessed the impact of TBIL and DBIL on hematological malignancies. For this study, the inverse variance weighting method (IVW) was the primary method of MR analysis. In the sensitivity analysis, the weighted median method, MR Egger regression, and MR-PRESSO test were used. To understand the mechanisms behind TBIL and DBIL, we used three different approaches based on screening single nucleotide polymorphisms (SNPs) and their associated genes, followed by bioinformatics analysis.ResultsThe IVW test results showed evidence of effects of TBIL (odds ratio [OR]: 4.47, 95% confidence interval [CI]: 1.58-12.62) and DBIL (OR: 3.31, 95% CI: 1.08-10.18) on the risk of acute myeloid leukemia (AML).The findings from bioinformatics indicated that TBIL could potentially undergo xenobiotic metabolism through cytochrome P450 and contribute to chemical carcinogenesis.DiscussionIn this study, two-sample MR analysis revealed a causal relationship between TBIL, DBIL, and AML.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic prediction of causal association between serum bilirubin and hematologic malignancies: a two-sample Mendelian randomized and bioinformatics study

Lu,

Luo,

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Moore et al (2018) proved that BRCA1/2 mutation carriers reap greater benefits from olaparib maintenance therapy in ovarian cancer ( Moore et al, 2018 ). Additionally, UGT1A1 polymorphism influenced clinical outcome in patients undergoing cytarabine chemotherapy for moderate critical myeloid leukemia ( Díaz-Santa et al, 2020 ). The evidence presented that drug metabolism-related genes are crucial for personalized cancer therapy to get a better outcome for patients.…”

Section: Discussionmentioning

confidence: 99%

The Roles of Drug Metabolism-Related ADH1B in Immune Regulation and Therapeutic Response of Ovarian Cancer

Peng

Kang

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Background: The different pharmacological effects of drugs in different people can be explained by the polymorphisms of drug metabolism-related genes. Emerging studies have realized the importance of drug metabolism-related genes in the treatment and prognosis of cancers, including ovarian cancer (OV). In this study, using comprehensive bioinformatics and western blot, we identified that the drug metabolism-related gene, ADH1B, was significantly down-regulated in OV cells and tissues. The patients with a high level of ADH1B presented a good prognosis. We also found a negative correlation between ADH1B expression and the activity of chemotherapeutic agents, such as cyclophosphamide. In addition, positive correlations were observed between ADH1B expression and multiple immune checkpoints, including LAG3 and HAVCR2. The immune infiltration analysis further indicated that aberrantly expressed ADH1B might have important roles in regulating the infiltration of macrophages and neutrophils in OV tissues. Then, the co-expression analysis was conducted and the top three enriched KEGG pathways were spliceosome, RNA transport, and DNA replication. In conclusion, the drug metabolism-related gene ADH1B and its interactive network play an essential role in the immune regulation and therapeutic response and maybe identified as promising therapeutic targets for OV patients.

show abstract

“…Moore et al (2018) proved that BRCA1/2 mutation carriers reap greater benefits from olaparib maintenance therapy in ovarian cancer (Moore et al, 2018). Additionally, UGT1A1 polymorphism influenced clinical outcome in patients undergoing cytarabine chemotherapy for moderate critical myeloid leukemia (Díaz-Santa et al, 2020). The evidence presented that drug metabolism-related genes are crucial for personalized cancer therapy to get a better outcome for patients.…”

Section: Discussionmentioning

confidence: 99%

Image1.TIF

View full text Add to dashboard Cite

UGT1A1 genotype influences clinical outcome in patients with intermediate-risk acute myeloid leukemia treated with cytarabine-based chemotherapy

Cited by 10 publications

References 20 publications

Genetic prediction of causal association between serum bilirubin and hematologic malignancies: a two-sample Mendelian randomized and bioinformatics study

Genetic prediction of causal association between serum bilirubin and hematologic malignancies: a two-sample Mendelian randomized and bioinformatics study

The Roles of Drug Metabolism-Related ADH1B in Immune Regulation and Therapeutic Response of Ovarian Cancer

Image1.TIF

Contact Info

Product

Resources

About