2009
DOI: 10.3109/03602530903210682
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UGT genomic diversity: beyond gene duplication

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Cited by 121 publications
(47 citation statements)
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“…However, underlying factors (LATFs, liver-enriched transcription factors as well as genetic diversity [64]) are difficult to distinguish. In addition, recent evidence supports the concept that UGT proteins interact as dimers/oligomers which may have implications for structure, function and substrate specificity of UGTs [65].…”
Section: Species Differences Of Rat and Human Hepatic Ugt Induction Bmentioning
confidence: 99%
“…However, underlying factors (LATFs, liver-enriched transcription factors as well as genetic diversity [64]) are difficult to distinguish. In addition, recent evidence supports the concept that UGT proteins interact as dimers/oligomers which may have implications for structure, function and substrate specificity of UGTs [65].…”
Section: Species Differences Of Rat and Human Hepatic Ugt Induction Bmentioning
confidence: 99%
“…2) [25]. UGT enzymes are widely and differentially expressed throughout the human body [26]. Although the majority of UGT enzymes are expressed in the liver, UGT1A7, 1A8, and 1A10 are expressed exclusively extrahepatically, mainly in the intestine [27,28]; UGT1A9, 2B7, and 2B11 are expressed at relatively high amounts in the kidney.…”
Section: Glucuronidation Enzymesmentioning
confidence: 99%
“…This post-transcriptional mechanism has been reported for genes involved in drug metabolism, most notably cytochrome P450 (P450) (Turman et al, 2006), sulfotransferases (He et al, 2005), glutathione S-transferase (Ross and Board, 1993), and UDP-glucuronosyltransferases (UGTs) . UGT1A family members are derived from the use of alternative promoters and exons 1, whereas UGT2B7 is subjected to extensive alternative splicing (Innocenti et al, 2008;Guillemette et al, 2010;Ménard et al, 2011).…”
Section: Introductionmentioning
confidence: 99%