Ugi bisamides based on pyrrolyl-β-chlorovinylaldehyde and their unusual transformations
Alexander V Tsygankov,
Vladyslav O Vereshchak,
Tetiana O Savluk
et al.
Abstract:By one-pot four- and three-component Ugi reactions involving convertible isocyanides and unexplored pyrrole-containing β-chlorovinylaldehyde, a small library of 20 bisamides with unusual behavior in post-Ugi transformations was prepared and characterized. Surprisingly, a well-documented approach to obtain peptide-containing carboxylic acids through acid hydrolysis of the convertible isocyanide moiety in the Ugi bisamides proceeded in an unexpected manner in our case, leading to the formation of derivatives of … Show more
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