Ueber elliptische rote Blutkörperchen

Abstract

van den Bergh in Utrecht. Im Archiv für Verdauungskrankheiten 1928 Bd. 43 (Festschrift für B o a s) habe ich über ein junges Mädchen berichtet, dessen rote Blutkörperchen in einem großen Prozentsatz elliptische Gestalt zeigten. Auch der Vater und zwei Schwestern, alle drei vollkommen gesunde Menschen, zeigten in ihrem Blute überaus zahlreiche Ellipse. Dieser Befund war mir ganz fremd, bis ich zufälligerweise, da ich mich mit der Literatur über die Sickle cell anaemia beschäftigte, in der amerikanischen Zeitschrift, Arch. of mt. Med., zwei ähnlichen Fällen begegnete. Weitere Mitteilungen über diesen Zustand konnte

Highly Sensitive and Selective Sensing of Free Bilirubin Using Metal–Organic Frameworks-Based Energy Transfer Process

“…Bilirubin, the breakdown product of hemoglobin turnover, is largely associated with jaundice. Generally, bilirubin is divided into three categories, total bilirubin, direct bilirubin, and free bilirubin. , Free bilirubin plays a significant role in tissue uptake and toxicity of bilirubin, and acts as a determinant in the pathogenesis of jaundice. , The normal concentration level of free bilirubin is <25 μmol/L in human serum, and the level is increased to >50 μmol/L under jaundice condition. , When the function of liver is impaired, free bilirubin cannot be adequately eliminated. Excess free bilirubin can accumulate in body organs and cause jaundice, brain damage, or even death. , Therefore, it is desirable to monitor the concentration of free bilirubin in human serum for diagnosing jaundice and liver disorder.…”

Self-Assembly in Tailor-Made Polyfluorenes: Synergistic Effect of Porous Spherical Morphology and FRET for Visual Sensing of Bilirubin

“…For instance, increased levels of conjugated bilirubin in serum could signal disturbance of bile drainage as in obstructive jaundice or increased levels of unconjugated bilirubin could be due to abnormally high breakdown of hemoglobin (hemolysis). , Therefore, monitoring the bilirubin concentration in body fluids is a vital step in diagnosing liver disorders and jaundice. Clinically, the levels of bilirubin (conjugated and unconjugated bilirubin) is determined by the color change from yellow to red produced by the diazotization reaction of bilirubin and sulphanilic acid using spectrophotometer (total van den Bergh reaction, 1914). , The major disadvantage of the assay is that it overestimates conjugated bilirubin and is time-consuming (30 min to develop the maximum color) . There are only very few reports on fluorimetric bilirubin sensing; very recently a spectrofluorometric method of determination of free bilirubin by Kleinfeld et.al was described using mutated fatty acid binding protein labeled with the fluorescent molecule acrylodan or rhodamine-B, whose fluorescence changed upon binding to bilirubin .…”