1894
DOI: 10.1002/cber.189402702229
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Ueber eine Darstellungsweise der Glutarsäure

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Cited by 219 publications
(104 citation statements)
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“…Knoevenagel condensation is one of the well well documented reactions for forming electrophilic olefins and C-C bond between carbonyl compounds and active methylene compounds. This reaction is a practical method to achieve fine chemical intermediates and therapeutic and pharmacological products [1][2][3] . Owing to their impor tance from an industrial, pharmacological and synthetic point of view a great number of methods for the Knoevenagel condensation have been developed using various Lewis acids/bases under ultrasound and microwave irridiation, using green solvent like water or ionic liquid, and grindstone method under solvent-free condition [4][5][6][7][8][9][10][11][12] .…”
Section: Introductionmentioning
confidence: 99%
“…Knoevenagel condensation is one of the well well documented reactions for forming electrophilic olefins and C-C bond between carbonyl compounds and active methylene compounds. This reaction is a practical method to achieve fine chemical intermediates and therapeutic and pharmacological products [1][2][3] . Owing to their impor tance from an industrial, pharmacological and synthetic point of view a great number of methods for the Knoevenagel condensation have been developed using various Lewis acids/bases under ultrasound and microwave irridiation, using green solvent like water or ionic liquid, and grindstone method under solvent-free condition [4][5][6][7][8][9][10][11][12] .…”
Section: Introductionmentioning
confidence: 99%
“…All the melting points were determined on Perfit melting point apparatus and are uncorrected. 1 H NMR spectral data was registered on Bruker DPX-200 NMR spectrometer (200 MHz) in CDCl 3 using tetramethylsilane as an internal standard. The IR spectra were recorded using KBr disc on Perkin-Elmer FTIR spectrophotometer.…”
Section: Methodsmentioning
confidence: 99%
“…This has made the synthesis of compounds containing indole moiety an interesting target for synthetic organic chemists. The Knoevenagel condensation 4 of substituted aromatic aldehydes with active methylene compounds is an important and widely employed method for carbon-carbon bond formation in organic synthesis with numerous applications in the construction of different types of organic molecules of biological significance. The reactions are usually catalyzed by bases 5 such as aliphatic amines, ethylenediamine and piperidine or their corresponding ammonium salts, ammonia or sodium ethoxide in organic solvents.…”
Section: Introductionmentioning
confidence: 99%