Ueber die secernirenden Zellen des Dünndarm-Epithels

Paneth, Josef

doi:10.1007/bf02955706

Cited by 121 publications

(49 citation statements)

References 12 publications

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“…1 and 2) (303,347). These cells, one of the four major epithelial cell lineages present in the intestine, are present at the base of the crypts of Lieberkühn in mammals and play a pivotal role in the enteric defense against pathogenic harmful bacterial intruders.…”

Section: Intestinal Cells That Produce Antimicrobial Peptidesmentioning

confidence: 99%

The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

2006

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SUMMARY The intestinal tract is a complex ecosystem that combines resident microbiota and the cells of various phenotypes with complex metabolic activities that line the epithelial wall. The intestinal cells that make up the epithelium provide physical and chemical barriers that protect the host against the unwanted intrusion of microorganisms that hijack the cellular molecules and signaling pathways of the host and become pathogenic. Some of the organisms making up the intestinal microbiota also have microbicidal effects that contribute to the barrier against enteric pathogens. This review describes the two cell lineages present in the intestinal epithelium: the goblet cells and the Paneth cells, both of which play a pivotal role in the first line of enteric defense by producing mucus and antimicrobial peptides, respectively. We also analyze recent insights into the intestinal microbiota and the mechanisms by which some resident species act as a barrier to enteric pathogens. Moreover, this review examines whether the cells producing mucins or antimicrobial peptides and the resident microbiota act in partnership and whether they function individually and/or synergistically to provide the host with an effective front line of defense against harmful enteric pathogens.

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Section: Intestinal Cells That Produce Antimicrobial Peptidesmentioning

confidence: 99%

The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

2006

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“…Although the cause of CR-PaM is unclear, regeneration and destruction by inflammation as well as abnormalities of bloody microcirculation and/or immunodefense abnormalities may be thought to induce CR-PaM, considering the functions of Paneth cells [4, 5]. Anyway, it should be assumed that some nonspecific inflammation induces CR-PaM.…”

Section: The Coexistence Of Colorectal Pam and Cr-enmentioning

confidence: 99%

“…Paneth cells, which are usually situated at the base of the glands of the small intestine, were first identified by Schwalbe [4] in 1872 and studied in detail morphologically by Paneth [5] in 1888.…”

Section: The Coexistence Of Colorectal Pam and Cr-enmentioning

confidence: 99%

Proposal of a New Hypothesis on the Development of Colorectal Epithelial Neoplasia: Nonspecific Inflammation – Colorectal Paneth Cell Metaplasia – Colorectal Epithelial Neoplasia

Wada

2009

Digestion

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Colorectal epithelial neoplasia (CR-EN), both adenoma and adenocarcinoma, may develop from the essential tubules of the colorectum. In order to conclude the carcinogenesis of the colorectal cancer more clearly, the biological features including the genetic abnormality of the nonneoplastic mucosal epithelium of colon and rectum, which coexist in connection with CR-EN, should be investigated. In this review, the importance of Paneth cell metaplasia of colorectum as one of the original mucosal regions of the development of CR-EN, and the new hypothesis on the development of CR-EN (nonspecific inflammation – colorectal Paneth cell metaplasia – colorectal epithelial neoplasia) are examined.

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“…Instead, the origin of the goblet cells has been given much attention (12,22) and according to some authors appears to be sufficiently clear (13,15,17).…”

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confidence: 99%

Quantitative Changes in the Goblet Cells of the Rat Small Intestine after Irradiation

Becciolini

Fabbrica

Cremonini

et al. 1985

Acta Radiologica: Oncology

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Ueber die secernirenden Zellen des Dünndarm-Epithels

Abstract: Paneth cells in the largc intestine in ulcerative colitis. J. Path. Bact. 80: 309-316, 1960. 22. Verity, M. A., Mellinkoff, S. M., Frankland, A. B., and Greipel, M.: Serotonin content and argentaffin and Paneth cell changes in ulcerative colitis.

Cited by 121 publications

References 12 publications

The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

Proposal of a New Hypothesis on the Development of Colorectal Epithelial Neoplasia: Nonspecific Inflammation – Colorectal Paneth Cell Metaplasia – Colorectal Epithelial Neoplasia

Quantitative Changes in the Goblet Cells of the Rat Small Intestine after Irradiation

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