Ueber das Verhalten der Wandungen der Blutgefässe bei der Emigration weisser Blutkörper

A brief survey of the history of inflammation

“…For Virchow 'the inflammatory process derives frorn the increased activity (nutritive irritability) of the cell to find the appropriate source of food in the surrounding tissues; in such a way, the inflammatory reaction is consequence of an excessive intake by interstitial cells, of food provenient from the liquid part of the blood, filtering through the vessel wall' [1]. A great support to such a view was the demonstration by ARNOLD (1875) [4] of the phenomenon of diapedesis. I dare say that this approach to the inflammatory reaction is still very dear to our biochemists, in a certain way opposite to that sponsored by Cohnheim and his pupils, who stated in 1873: 'I consider indisputable (note how easy it was to explain anything in science, when there were only few people investigating), that the cause of inflammation must be found in the vessels themselves, everything that occurs outside of the vessels gives the impression of secondary phenomena' [2].…”

The Role of White Blood Cells in Post-Mortem Wounds

“…The adhesive property of the endothelium at this stage might be due to the formation of cement substance that could be considered as fibrin (Arnold, 1875), gelatinous material (Zweifach, 1953), mucoprotein or mucopolysaccharide (Luft, 1964a) or it might be due to electrochemical factors in which divalent cations, such as calcium ions might playa key role in leucocytic adhesion (Bangham, 1964).…”

Migration of Leukocytes across Endothelial Junctions: Some Concepts and Controversies

“…Although most scientists consider migration via junctions to be an established fact, the area has continued to be controversial. Despite innumerable reports documenting leukocyte migration via junctions by intravital microscopy beginning in the 1870s (5) and by electron microscopy in the 1960s (46), reports of leukocyte migration through endothelial cytoplasm, bypassing the junction, continue to be published (6,32). Although some of these data are quite striking, these electron micrographs of leukocytes surrounded by membrane at a distance from structurally recognizable junctions were always dismissed as inadequate proof, because the leukocyte could have been in continuity with recognizable junctional structures out of the plane of sectioning.…”