Udział lipidów w regulacji prozapalnych szlaków sygnałowych indukowanych przez lipopolisacharyd

Kwiatkowska, Katarzyna; Ciesielska, Anna

doi:10.18388/pb.2018_129

Cited by 11 publications

(5 citation statements)

References 76 publications

(108 reference statements)

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“…23 In particular, they produce large amounts of IL-1β, IL-6 and IL-8. [24][25][26] Intravenous immunoglobulin could limit the production of inflammatory cytokines, such as TNF-α, IL-1β and Fig. 1.…”

Section: Discussionmentioning

confidence: 99%

Fc-gamma receptor expression and cytokine responses to intravenous human immunoglobulin in whole blood from non-pregnant and pregnant women and newborns

Vázquez-Rodríguez,

Arriaga-Pizano,

Mancilla-Herrera

et al. 2024

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 99%

Fc-gamma receptor expression and cytokine responses to intravenous human immunoglobulin in whole blood from non-pregnant and pregnant women and newborns

Vázquez-Rodríguez,

Arriaga-Pizano,

Mancilla-Herrera

et al. 2024

Adv Clin Exp Med

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“…Emerging evidence demonstrates that palmitoylation is involved in LPS-induced macrophage activation. A proteomics study using RAW264 macrophage-like cells reveals that LPS stimulates global changes in protein palmitoylation, affecting nearly 340 palmitoylated proteins (Kwiatkowska and Ciesielska, 2018). More importantly, TLR signaling in macrophages is regulated by many palmitoylated proteins.…”

Section: Pathogen Recognition Tlr Signaling Pathwaymentioning

confidence: 99%

Protein Palmitoylation in Leukocyte Signaling and Function

Yang

Chatterjee

et al. 2020

Front. Cell Dev. Biol.

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Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of enzymes: palmitoyl acyltransferases containing a zinc finger aspartate-histidine-histidine-cysteine motif (PAT-DHHCs) and thioesterases. The reversible nature of palmitoylation enables fine-tuned regulation of protein conformation, stability, and ability to interact with other proteins. More importantly, the proper function of many surface receptors and signaling proteins requires palmitoylation-meditated partitioning into lipid rafts. A growing number of leukocyte proteins have been reported to undergo palmitoylation, including cytokine/chemokine receptors, adhesion molecules, pattern recognition receptors, scavenger receptors, T cell co-receptors, transmembrane adaptor proteins, and signaling effectors including the Src family of protein kinases. This review provides the latest findings of palmitoylated proteins in leukocytes and focuses on the functional impact of palmitoylation in leukocyte function related to adhesion, transmigration, chemotaxis, phagocytosis, pathogen recognition, signaling activation, cytotoxicity, and cytokine production.

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“…Cytokine overproduction is related to the dysregulation of lipid metabolism induced by LPS. 5 For example, when LPS stimulates macrophages, CD14 aggregates in the plasma membrane, causing bidirectional buildup of phosphatidylinositol 4,5-bisphosphate [PI (4,5) P2], which in turn regulates two important inflammatory signaling pathways of TLR4 (Myd88 and TRIF-dependent pathways). PI (4,5) P2 regulates cytokine production by modulating the TLR4 pro-inflammatory signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

“…Figure5 Comparison of differential lipids in plasma and testis between LPS group and control group. (A) Plasma, (B) Testis Based on the screening criteria of VIP>1andP<0.05, a total of 146 differential lipids were screened in plasma, 103 (70.5%) were up-regulated and 43 (29.5%) were down-regulated.…”

mentioning

confidence: 99%

Is Lipopolysaccharide-Induced Lipid Metabolism Disorder in Testis of Rats a Consequence of Plasma Lipid Changes?

Zheng,

Li,

Shang

et al. 2024

JIR

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Purpose The systemic infection and inflammation can result in testes injury, whereas the exact mechanism is unknown. The lipid metabolism has a dual impact on controlling metabolism and inflammation, which is a potential pathway. The objective of this study was to determine if changes in plasma lipids during lipopolysaccharide (LPS)-induced systemic inflammation affect the dysregulation of testes lipid metabolism. Materials and Methods LPS (5 mg/kg) was used to induce systemic inflammation in rats after a single intraperitoneal injection. After 4 weeks, the rats were sacrificed, and the serum and testes were used for laboratory measurements and histology examination. Plasma and testis were used for lipidomics analysis based the liquid chromatography-mass spectrometry. Spearman rank correlation analysis was used to compare the correlation of differential lipids in phospholipids, glycerolipids, and sphingolipids between testis and plasma. Results LPS raised the levels of cytokines in serum and testis, decreased the activities of antioxidant enzymes, increased the levels of lipid peroxidation products, and damaged testis tissue. In testis and plasma, 146 and 401 differential lipids, mostly phosphatidylcholine, phosphatidylethanolamine an so on, were found in comparison to the control group. Correlation analysis produced a total of 2528 correlation coefficients, 1150 of which were P<0.05 and accounted for 45.49%. Conclusion The changes of lipid composition and content in the testis are related to cytokine overload and oxidative stress. Testis lipid metabolism disorders caused by LPS-induced systemic inflammation are lack of a correlation with plasma lipid changes, and are likely owing to interference with the testis itself.

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Udział lipidów w regulacji prozapalnych szlaków sygnałowych indukowanych przez lipopolisacharyd

Cited by 11 publications

References 76 publications

Fc-gamma receptor expression and cytokine responses to intravenous human immunoglobulin in whole blood from non-pregnant and pregnant women and newborns

Fc-gamma receptor expression and cytokine responses to intravenous human immunoglobulin in whole blood from non-pregnant and pregnant women and newborns

Protein Palmitoylation in Leukocyte Signaling and Function

Is Lipopolysaccharide-Induced Lipid Metabolism Disorder in Testis of Rats a Consequence of Plasma Lipid Changes?

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