Ubp43 gene expression is required for normal Isg15 expression and fetal development

Rempel, Lea A.; Austin, Kathy J.; Ritchie, Kenneth J.; Yan, Ming; Shen, Mei-Feng; Zhang, Dong‐Er; Henkes, Luiz Ernani; Hansen, Thomas

doi:10.1186/1477-7827-5-13

Cited by 21 publications

(21 citation statements)

References 53 publications

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“…Usp18 (ubiquitin specific peptidase 18, also known as Ubp43), is an Isg15-specific protease that is up-regulated in response to interferon or lipopolysaccaride. Its gene expression is required for normal Isg15 expression (Rempel et al 2007). Oasl2 (2 0 -5 0 oligoadenylate synthetase-like 2), the third most predominantly up-regulated gene in the duodenum of Car6 -/-mice, is an allergy/inflammationrelated gene belonging to the 2 0 -5 0 oligoadenylate synthetase family, which was one of the first characterized IFN-induced antiviral proteins (Eskildsen et al 2003).…”

Section: Discussionmentioning

confidence: 98%

Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

et al. 2010

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Carbonic anhydrase VI (CAVI) is the only secreted isozyme of the α-carbonic anhydrase family, which catalyzes the reversible reaction [Formula in text]. It appears that CAVI protects teeth and gastrointestinal mucosa by neutralizing excess acidity. However, the evidence for this physiological function is limited, and CAVI may have additional functions that have yet to be discovered. To explore the functions of CAVI more fully, we generated Car6 (-/-) mice and analyzed Car6 (-/-) mutant phenotypes. We also examined transcriptomic responses to CAVI deficiency in the submandibular gland, stomach, and duodenum of Car6 (-/-) mice. Car6 (-/-) mice were viable and fertile and had a normal life span. Histological analyses indicated a greater number of lymphoid follicles in the small intestinal Peyer's patches. A total of 94, 56, and 127 genes were up- or down-regulated in the submandibular gland, stomach, and duodenum of Car6 (-/-) mice, respectively. The functional clustering of differentially expressed genes revealed a number of altered biological processes. In the duodenum, the significantly affected biological pathways included the immune system process and retinol metabolic processes. The response to oxidative stress and brown fat cell differentiation changed remarkably in the submandibular gland. Notably, the submandibular gland, stomach, and duodenum shared one important transcriptional susceptibility pathway: catabolic process. Real-time PCR confirmed an altered expression in 14 of the 16 selected genes. The generation and of Car6 (-/-) mice and examination of the effects of CAVI deficiency on gene transcription have revealed several affected clusters of biological processes, which implicate CAVI in catabolic processes and the immune system response.

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Section: Discussionmentioning

confidence: 98%

Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

et al. 2010

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“…USP18 are believed to play essential roles in many biological functions, such as host innate immune response (Randall et al, 2006), brain cell injury , fetal development (Rempel et al, 2007), pancreatic beta cell inflammation and apoptosis (Santin et al, 2012) and so on. Recently the role of mammalian USP18 in viral infections was most comprehensively studied, indicating that this role is mediated both via its ISG15 protease action and in proteaseindependent fashions (Chen et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Expression characterization, genomic structure and function analysis of fish ubiquitin-specific protease 18 (USP18) genes

Chen¹,

Zhang²,

Gui³

2015

Developmental & Comparative Immunology

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“…Furthermore, a recent study showed that Isg15 is expressed in both the antimesometrial plus mesometrial decidua and placenta on Days 12.5 and 17.5 of murine pregnancy, after decidualization is complete (Rempel and others, '07). Therefore, ISG15 likely also plays a role in the post-decidualization period.…”

Section: Assessing Expression Of Genes One-by-one: What Have We Learned?mentioning

confidence: 99%

“…Therefore, ISG15 likely also plays a role in the post-decidualization period. Although Isg15 knockout mice appear to have no problems during pregnancy (Osiak and others, '05), it has been suggested this observation may depend on their genetic background (Rempel and others, '07). Regardless, it seems that Isg15 is not absolutely required for successful pregnancy.…”

Section: Assessing Expression Of Genes One-by-one: What Have We Learned?mentioning

confidence: 99%

“…Regardless, it seems that Isg15 is not absolutely required for successful pregnancy. This implication is complicated further by the finding that mice deficient in functional ubiquitin specific peptidase 18 (USP18), a protease that de-conjugates ISG15 from proteins, have abnormal placentas and suffer from significant fetal loss (Rempel and others, '07). …”

Section: Assessing Expression Of Genes One-by-one: What Have We Learned?mentioning

confidence: 99%

See 1 more Smart Citation

Do molecular signals from the conceptus influence endometrium decidualization in rodents?

Herington

Bany

2009

J Exp Zool Pt B

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A critical period in establishing pregnancy occurs after the onset of implantation but before placental development. Evidence strongly suggests that abnormalities occurring during this period can result in pregnancy termination or in pre-eclampsia; the latter may lead to small-for-gestational-weight offspring that are likely to be unhealthy. Clearly, events occurring in the endometrium during the implantation process are crucial for proper fetal development and for optimal offspring health. In several mammalian species bi-directional communication between the conceptus and endometrium during implantation is required for successful pregnancy. Although different implantation and placentation modes occur in different mammalian species, common aspects of this bi-directional signaling may exist. The molecular signals from the trophoblast cells of the conceptus, which direct endometrial changes during implantation progression, are well known in some non-rodent species. Currently, we know little about such signaling in rodents during implantation progression, when the endometrium undergoes decidualization. This review focuses on data that support the hypothesis that paracrine signals from the rodent conceptus influence decidualization. Where possible, these findings are compared and contrasted to information currently known in other species that exhibit different implantation modes.

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Ubp43 gene expression is required for normal Isg15 expression and fetal development

Cited by 21 publications

References 53 publications

Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

Expression characterization, genomic structure and function analysis of fish ubiquitin-specific protease 18 (USP18) genes

Do molecular signals from the conceptus influence endometrium decidualization in rodents?

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