Ubiquitination of molluscum body and its implications for pathophysiology

Yoneda, Kozo; Demitsu, Toshio; Kon, Atsushi; Sadahira, Chieko; Moriue, Tetsuya; Katsuura, Junko; Matsuoka, Yoshie; Takai, Idris Usman; Noda, Masanori; Inagaki, Nobuya; Kubota, Yasuo

doi:10.1111/j.1365-2133.2006.07147.x

Cited by 11 publications

(9 citation statements)

References 13 publications

(17 reference statements)

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“…Recently, we have reported that ubiquitination is involved in the elimination of molluscum bodies 1 . We found increased expression of ubiquitin in the molluscum bodies from several healthy infants.…”

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confidence: 59%

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Attenuated ubiquitination of molluscum bodies in agminated mollusca contagiosa associated with malignant lymphoma

Demitsu

Yoneda

Umemoto

et al. 2007

Acad Dermatol Venereol

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and histopathologically (absence of haemorrhage and haemosiderin deposition). 1 The targetoid combined blue naevus has only two discrete areas representing dermal and epidermal melanocytic proliferations. 2 Because of this distinctive morphology of an otherwise usual, compound melanocytic naevus, we coined the term naevus en cocarde or hoop-loop naevus. References1 Tomasini C, Broganelli P, Pippione M. Targetoid hemosiderotic nevus. A trauma-induced simulator of malignant melanoma. Dermatology 2005; 210: 200 -205. 2 Argenziano G. Dermoscopy of melanocytic neoplasms: targetoid combined blue nevi.

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confidence: 59%

“…In our recent study, ubiquitination was strongly expressed within the skin lesions of molluscum contatigiosum in healthy infants 1 . We describe a case of agminated mollusca contagiosa with attenuated ubiquitination of molluscum bodies, with underlying malignant lymphoma.…”

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confidence: 70%

Attenuated ubiquitination of molluscum bodies in agminated mollusca contagiosa associated with malignant lymphoma

Demitsu

Yoneda

Umemoto

et al. 2007

Acad Dermatol Venereol

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“…74 Extensive lesions can occur in immunocompromised patients, particularly those with AIDS. 86 Apoptosis is not increased in active lesions. 85 An additional mechanism appears to be involved in regression.…”

Section: Cowpoxmentioning

confidence: 97%

“…73 Antibodies to the virus have been found in nearly 60% of patients with skin lesions, suggesting a role for humoral immunity, but antibodies are less frequent in patients with AIDS. 86 This involves the ubiquitin-proteasome system (UPS). [75][76][77][78][79][80][81][82][83][84] Disseminated lesions can occur in HTLV-1 infection as well.…”

Section: Cowpoxmentioning

confidence: 99%

Viral diseases

Weedon

2010

Weedon's Skin Pathology

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“…2 a-c). Next, immunofluorescence using anti-cleaved caspase 3 (Asp175) rabbit polyclonal antibody (Cell Signaling Technology, Beverly, MA, USA) was performed on deparaffinized lesional skin sections (5,6). Keratinocytes with shrunken nuclei showed cleaved caspase 3 in both the cytoplasm and the nucleus (Fig.…”

Section: Case Reportmentioning

confidence: 99%

Detection of Apoptotic Keratinocytes in a Case of Bullous Pemphigoid Developed after Graft-versus-host Disease

Yoneda¹,

Demitsu²,

Kakurai³

et al. 2014

Acta Derm Venerol

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Graft-versus-host disease (GVHD) is a frequent complication following haematopoietic stem cell transplantation. GVHD reveals various skin lesions, such as maculo-papular rash, brownish pigmentation, and scleroderma (1). Although GVHD may present subepidermal blisters caused by vacuolar degeneration of basal cells, the association of bullous pemphigoid (BP) and GVHD is extremely rare (1).We report here a case of BP that developed 4 months after allogeneic bone marrow transplantation (BMT). Interestingly, histopathology revealed necrotic keratinocytes scattered in the spongiotic epidermis, composed of subepidermal blister roof. We further investigated the necrotic keratinocytes for the presence of apoptotic cells and cleaved caspase 3. CASE REPORTA 57-year-old Japanese woman was diagnosed with acute myelogenous leukaemia in November 2002. She achieved complete remission after chemotherapy with cytarabine, daunorubicin and gemcitabine. In June 2004, the patient underwent allogeneic BMT from her human leukocyte antigen (HLA)-identical older sister. GVHD prophylaxis was attempted with cyclosporine and short-term treatment with methotrexate. Complete remission of the acute myelogenous leukaemia and 100% donor chimerism were confirmed. In October 2004 (4 months after BMT), extensive exudative erythemas with blisters appeared over the patient's entire body surface (Fig. 1a). A biopsy from a fresh vesicle showed subepidermal blistering and moderate infiltration of both eosinophils and lymphocytes in both the dermis and the bulla (Fig. 1b). Dyskeratotic keratinocytes were observed in the epidermis at the roof of the bulla with spongiosis (Fig. 1b, c). Shrunken keratinocytes were also demonstrated in the blister roof of different blisters (Fig. 1d). Direct immunofluorescence of skin biopsy showed linear immunoglobulin G (IgG) deposition in the epidermal basement membrane zone (BMZ). Indirect immunofluorescence of normal human skin revealed circulating IgG anti-BMZ antibodies. Indirect immunofluorescence of 1 M sodium chloride (NaCl)-split skin sections showed IgG reactivity with the epidermal side of the split (Fig. 1e). No circulating anti-BMZ antibodies were detected in the older sister. BP180 and BP230 enzyme-linked immunosorbent assays (ELISAs) of the sera from the patient and her sister were negative. Immunoblot analysis of normal human epidermal extracts did not detect IgG antibodies to either BP180 or BP230. Immunoblot analysis of recombinant proteins of NC16a and C-terminal domains of BP180 showed negative results. Oral prednisolone, 1 mg/kg/day, was started, leading to complete disappearance of the skin lesions within one month. Oral prednisolone was discontinued 6 months later. One year later, the patient died from brain metastasis of leukaemia and progressive renal failure. In order to characterize the necrotic keratinocytes in the blister roof, we conducted transferase dUTP nick end labelling (TUNEL) staining with the ApopTag Plus Fluorescein In Situ Apoptosis Detection Kit (Merck Millipore, Darmstadt, Germany)...

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Ubiquitination of molluscum body and its implications for pathophysiology

Abstract: References1 Gupta AK, Ryder JE, Nicol K, Cooper EA. Superficial fungal infections: an update on pityriasis versicolor, seborrheic dermatitis, tinea capitis, and onychomycosis.

Cited by 11 publications

References 13 publications

Attenuated ubiquitination of molluscum bodies in agminated mollusca contagiosa associated with malignant lymphoma

Attenuated ubiquitination of molluscum bodies in agminated mollusca contagiosa associated with malignant lymphoma

Viral diseases

Detection of Apoptotic Keratinocytes in a Case of Bullous Pemphigoid Developed after Graft-versus-host Disease

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